2 results match your criteria: "Tongji UniversityShanghai 200120[Affiliation]"
A dual-regulated oncolytic adenovirus carrying TAp63 gene exerts potent antitumor effect on colorectal cancer cells.
Am J Transl Res
June 2017
Department of Gastrointestinal Surgery, Shanghai East Hospital, School of Medicine, Tongji UniversityShanghai 200120, P. R. China.
Article Synopsis
- The study investigates the antitumor effects of a specially engineered adenovirus (Ad-survivin-ZD55-TAp63) that carries the TAp63 gene against colorectal cancer.
- The virus was confirmed to work through lab tests, showing it effectively targets colorectal cancer cells (HCT-116) while sparing normal liver cells (L-O2) and inducing cell death.
- In animal models, the intratumoral injection of this virus significantly reduced tumor growth and promoted apoptosis, suggesting its potential as a treatment for colorectal cancer in future research.
A novel E1B55kDa-deleted oncolytic adenovirus carrying microRNA-143 exerts specific antitumor efficacy on colorectal cancer cells.
Am J Transl Res
September 2016
Department of Gastrointestinal Surgery, Shanghai East Hospital, School of Medicine, Tongji UniversityShanghai 200120, P. R. China; Department of General Surgery, Zhejiang Province Pinghu Second People's HospitalPinghu 314200, P. R. China.
Article Synopsis
- - The study explores the role of miR-143 in colorectal cancer (CRC), particularly how it targets the frequently mutated KRAS gene, which is important in cancer development.
- - Researchers created a special virus called Ad-ZD55-miR-143 to deliver miR-143 to cancer cells, and tests showed that it successfully increased miR-143 expression and significantly killed CRC cells while sparing normal liver cells.
- - Results indicated that Ad-ZD55-miR-143 effectively reduced KRAS levels in CRC cells and showcased potential as a targeted treatment approach for colorectal cancer.