KLRD1 (CD94): A Prognostic Biomarker and Therapeutic Candidate in Head and Neck Squamous Cell Carcinoma.

Killer Cell Lectin Like Receptor D1 (KLRD1) plays a crucial role in antitumor immunity. However, its expression patterns across various cancers, its relationship with patient prognosis, and its potential as an immunotherapy target remain inadequately understood. We analyzed KLRD1 expression across various cancer types using multi-omics data from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Gene Expression Omnibus (GEO) databases, correlating it with patient prognosis.

[Clinical efficacy of vitamin B1 in ICU-acquired weakness patients].

Objective: To observe the clinical efficacy of vitamin B1 in patients with ICU-acquired weakness (ICU-AW).

Methods: A retrospective analysis was conducted to select ICU-AW patients treated with vitamin B1 in the intensive care unit (ICU) of Shanghai East Hospital, Tongji University from July 2022 to December 2023. Propensity score matching was used to match the control group and observation group at a 1 : 1 ratio, considering differences in patient age, gender, and acute physiology and chronic health evaluation II (APACHE II).

[Expert consensus on ethical requirements for artificial intelligence (AI) processing medical data].

As artificial intelligence technology rapidly advances, its deployment within the medical sector presents substantial ethical challenges. Consequently, it becomes crucial to create a standardized, transparent, and secure framework for processing medical data. This includes setting the ethical boundaries for medical artificial intelligence and safeguarding both patient rights and data integrity.

Synthesis of anisotropic silica nanoparticles by organic amine with diverse structures.

Herein, we synthesized anisotropic silica nanoparticles (AISNPs) with organic amines with different structures. Monoamines and diamines with distance between amine groups shorter than4 Å have been observed to facilitate the formation of isotropic silica nanoparticles (ISNPs). AISNPs were synthesized with diamines with distance between amine groups longer than4 Å and linear structures of triamines.

The trunk segmental motion complexity and balance performance in challenging seated perturbation among individuals with spinal cord injury.

Background: Motion complexity is necessary for adapting to external changes, but little is known about trunk motion complexity during seated perturbation in individuals with spinal cord injury (SCI). We aimed to investigate changes following SCI in trunk segmental motion complexity across different perturbation directions and how they affect postural control ability in individuals with SCI.

Methods: A total of 17 individuals with SCI and 18 healthy controls participated in challenging sagittal-seated perturbations with hand protection.

Optimizing concrete sustainability with bagasse ash and stone dust and its impact on mechanical properties and durability.

Addressing environmental challenges such as pollution and resource depletion requires innovative industrial and municipal waste management approaches. Cement production, a significant contributor to greenhouse gas emissions, highlights the need for eco-friendly building materials to combat global warming and promote sustainability. This study evaluates the simultaneous use of Sugarcane Bagasse Ash (SCBA) and Stone Dust (SD) as partial replacements by volume for cement and sand, respectively, at varying ratios in eco-strength concrete mixes designed for 28 MPa (ES-28) and 34 MPa (ES-34), emphasizing their economic and environmental benefits.

Sprayable, antimicrobial and immunoregulation hydrogel loading exosomes based on oxidized sodium alginate for efficient wound healing at skin graft donor sites and health detection.

Skin grafting techniques are widely used for large burns, trauma, and various acute and chronic wounds, contributing greatly to the repair of traumatic tissue. However, donor site repair and regeneration are often neglected, resulting in infection and delayed healing. Therefore, it is crucial to reduce the rate of donor site infection and improve the speed and quality of healing.

Targeting macrophages in cancer immunotherapy: Frontiers and challenges.

Background: Cancer immunotherapy has emerged as a groundbreaking approach in cancer treatment, primarily realized through the manipulation of immune cells, notably T cell adoption and immune checkpoint blockade. Nevertheless, the manipulation of T cells encounters formidable hurdles. Macrophages, serving as the pivotal link between innate and adaptive immunity, play crucial roles in phagocytosis, cytokine secretion, and antigen presentation.

Nanomedicine-unlocked radiofrequency dynamic therapy dampens incomplete radiofrequency ablation-arised immunosuppression to suppress cancer relapse.

Incomplete radiofrequency ablation (iRFA) not only leaves residual tumor, but also render the residual tumor highly self-adaptable and immunosuppressive, consequently expediting residual tumor progression including relapse. To address it, radiofrequency dynamic therapy (RFDT) with identical trigger (namely radiofrequency) has been established and enabled by polyethylene glycol (PEG)-modified Fe-based single atom nanozyme (P@Fe SAZ). P@Fe SAZ can respond to radiofrequency field to produce reactive oxygen species (ROS), attaining the nanomedicine-unlocked low-temperature RFDT.

Trophic transfer of carbon-14 from algae to zebrafish leads to its blending in biomolecules and the dysregulation of metabolism via isotope effect.

Carbon-14 (C-14) has been a major contributor to the human radioactive exposure dose, as it is released into the environment from the nuclear industry in larger quantities compared to other radionuclides. This most abundant nuclide enters the biosphere as organically bound C-14 (OBC-14), posing a potential threat to public health. Yet, it remains unknown how this relatively low radiotoxic nuclide induces health risks via chemical effects, such as isotope effect.

Vitamin A and its influence on tumour extracellular matrix.

Vitamin A is a crucial nutrient renowned for its role in visual health and cellular regulation. Its derivatives influence cell differentiation, proliferation, and tissue homeostasis, making them significant in cancer research due to their effects on both normal and tumour cells. This review explores the intricate relationship between vitamin A metabolism and the extracellular matrix (ECM) in cancer.

Impact of DNAH3 Deficiency on Sperm Energy Metabolism and Motility Leading to Asthenozoospermia.

Asthenozoospermia, a prevalent contributor to male infertility, exhibits a multifaceted pathogenesis. This study identified a significant downregulation in sperm dynein heavy chain 3 (DNAH3) protein levels in individuals with asthenozoospermia. To elucidate the role of DNAH3 in asthenozoospermia, we constructed Dnah3-knockout (KO) mice, which exhibited asthenozoospermia and sterility.

FDG PET/CT in a Case of Metastasizing Pleomorphic Adenoma in the Ilium.

Although pleomorphic adenomas of the salivary glands are benign tumors, they can metastasize to distant organs without evidence of malignant transformation. We describe FDG PET/CT finding in a case of metastasizing pleomorphic adenoma in the right ilium occurring 22 years after initial surgical resection of a lip pleomorphic adenoma. On FDG PET/CT, the iliac metastasis appeared as an expansile osteolytic lesion with heterogeneous activity.

FDG PET/CT in a Case of Metastasizing Pleomorphic Adenoma in the Ilium.

Although pleomorphic adenomas of the salivary glands are benign tumors, they can metastasize to distant organs without evidence of malignant transformation. We describe FDG PET/CT finding in a case of metastasizing pleomorphic adenoma in the right ilium occurring 22 years after initial surgical resection of a lip pleomorphic adenoma. On FDG PET/CT, the iliac metastasis appeared as an expansile osteolytic lesion with heterogeneous activity.

FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction.

Colorectal cancer (CRC) is the most common gastrointestinal malignancy, and 5-Fluorouracil (5-FU) is the principal chemotherapeutic drug used for its treatment. However, 5-FU resistance remains a significant challenge. Under stress conditions, tumor metabolic reprogramming influences 5-FU resistance.

Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast.

It has been well validated that chronic psychological stress leads to bone loss, but the underlying mechanism remains unclarified. In this study, we established and analyzed the chronic unpredictable mild stress (CUMS) mice to investigate the miRNA-related pathogenic mechanism involved in psychological stress-induced osteoporosis. Our result found that these CUMS mice exhibited osteoporosis phenotype that is mainly attributed to the abnormal activities of osteoclasts.

Three-dimensional nonreciprocal transport in photonic topological heterostructure of arbitrary shape.

Electromagnetic wave propagation in three-dimensional (3D) space typically suffers omnidirectional scattering when encountering obstacles. In this study, we used Chern vectors to construct a topological heterostructure, where large-volume nonreciprocal topological transport in 3D is achieved. The shape of the cross section in the heterostructure can be arbitrary designed, and we experimentally observed the distinctive cross-shaped field pattern transport, nonreciprocal energy harvesting, and the remarkable ability of electromagnetic wave to traverse obstacles and abrupt structure changes without encountering reflections in 3D space.

Vaccine Therapies for Prostate Cancer: Current Status and Future Outlook.

Prostate cancer is a prevalent cancer in elderly men, and immunotherapy has emerged as a promising treatment approach in recent years. The aim of immunotherapy is to stimulate the body's immune system to target and destroy cancer cells. Cancer vaccines that are highly specific, safe, and capable of creating long-lasting immune responses are a key focus in cancer immunotherapy research.

Distributed Consensus Control for Discrete-Time T-S Fuzzy Multiple-Agent Systems Based on an Unknown Input Observer.

This paper investigates a consensus problem for a class of T-S fuzzy multiple-agent systems (MASs) with unknown input (UI). To begin with, an unknown input observer (UIO) is able to asymptotically estimate the system state and the UI is designed for each agent. In order to construct the UIO, the state interval estimation is obtained by first using zonotope theory.

Design and Evaluation of Ecological Interface of Driving Warning System Based on AR-HUD.

As the global traffic environment becomes increasingly complex, driving safety issues have become more prominent, making manual-response driving warning systems (DWSs) essential. Augmented reality head-up display (AR-HUD) technology can project information directly, enhancing driver attention; however, improper design may increase cognitive load and affect safety. Thus, the design of AR-HUD driving warning interfaces must focus on improving attention and reducing cognitive load.

Humanity Test-EEG Data Mediated Artificial Intelligence Multi-Person Interactive System.

Artificial intelligence (AI) systems are widely applied in various industries and everyday life, particularly in fields such as virtual assistants, healthcare, and education. However, this paper highlights that existing research has often overlooked the philosophical and media aspects. To address this, we developed an interactive system called "Human Nature Test".

Semantically-Enhanced Feature Extraction with CLIP and Transformer Networks for Driver Fatigue Detection.

Drowsy driving is a leading cause of commercial vehicle traffic crashes. The trend is to train fatigue detection models using deep neural networks on driver video data, but challenges remain in coarse and incomplete high-level feature extraction and network architecture optimization. This paper pioneers the use of the CLIP (Contrastive Language-Image Pre-training) model for fatigue detection.

Application of Phosphate-Based Binders for the Stabilization and Solidification of Metal-Contaminated Soil: Mechanisms and Efficacy Evaluation.

At present, contamination due to toxic metals is a global concern. The management of problems caused by heavy metals relies on stabilization/solidification, which is the most effective technique for the control of metal pollution in soil. This study examined the immobilization efficiency of various phosphate-based binders (NaPO, NaHPO, NaHPO), in addition to ordinary Portland cement (OPC), MgO, and CaO, for the stabilization of multi-metal-contaminated soils.

The Buckling Behavior and Reliability Evaluation of a Cable-Stayed Bridge with Unique-Shaped Towers.

Buckling is a significant concern for cable-stayed bridges that incorporate a large number of steel components, particularly those featuring unique-shaped towers that require further examination due to the intricate internal force and stress distribution. This paper investigates the buckling behavior of a cable-stayed bridge with inverted V-shaped towers. The cable tower is characterized by its unique design that consists of diagonal bracings and columns in a compression-bending state.

Evolution of Chemical, Structural, and Mechanical Properties of Titanium Nitride Films with Different Thicknesses Fabricated Using Pulsed DC Magnetron Sputtering.

Considering the application of titanium nitride (TiN) films as a release layer in producing Wolter-I X-ray telescope mirror shells by the electroformed nickel replication (ENR) technique, this research pays attention to the influence of nanometer-scale thickness variation in the microstructure and physical properties of TiN films deposited by the pulsed direct current (DC) magnetron sputtering method. This topic has received limited attention in the existing literature. TiN films (9.