Psychometric properties of the Chinese version of the Quiet Quitting Scale.

Background: The phenomenon of quiet quitting has attracted considerable attention within the nursing community. Elevated quiet quitting levels can weaken the work environment, reducing healthcare efficiency and quality. However, appropriate assessment tools to measure this phenomenon remain unavailable in China.

Can some algorithms of machine learning identify osteoporosis patients after training and testing some clinical information about patients?

Objective: This study was designed to establish a diagnostic model for osteoporosis by collecting clinical information from patients with and without osteoporosis. Various machine learning algorithms were employed for training and testing the model, evaluating its performance, and conducting validations to explore the most suitable machine learning algorithm.

Methods: Clinical information, including demographic data, examination results, medical history, and laboratory test results, was collected from inpatients with and without osteoporosis.

Spontaneous psoas hematoma following posterior lumbar fusion surgery: a mini literature review.

Background: Spontaneous psoas hematoma is a very rare clinical entity, and the pathogenesis and pathologic mechanisms of spontaneous psoas hematoma remain unclear, thus, it is of great value to explore.

Case Presentation: We encountered a patient who developed femoral nerve paralysis due to psoas muscle hematoma following posterior lumbar fusion surgery. A 69-year-old female with lumbar spinal canal stenosis underwent posterior lumbar fusion at the L3-4 and L4-5 levels.

Finite element analysis of retrograde superior ramus screw of pubis for the treament of pelvic anterior ring fracture.

Background: Retrograde superior ramus screw of pubis (SRSP) is a new kind of pelvic minimally invasive internal fixation apparatus developed by our team. The purpose of this study was to analyze the biomechanical stability of this new minimally invasive pelvic internal fixation device, and to provide this new device with theoretical basis for clinical application.

Methods: The Tile C1.

Prognostic value of tumor deposits and positive lymph nodes in colorectal cancer surgery: improved staging for long-term prognosis.

Background: To evaluate the prognostic value of the presence and number of tumor deposits (TDs) and the combination of TDs and number of positive lymph nodes (PLNs) in patients undergoing colorectal cancer (CRC) surgery, and to modify N staging.

Method: The clinical data of 1470 patients with stage I-IV CRC who underwent surgery in Wuhan Union Hospital from February 2014 to May 2018 were collected. The optimal cutoff value for TD + PLNs was obtained using X-tile software, and patients were regrouped accordingly.

Deep cutaneous fungal infection in an immunocompetent individual caused by a biological pesticide: a rare case report.

Background: Purpureocillium lilacinum is a type of fungus that is found all over the world and is known for its ability to help control pests, especially those that harm plants. Generally, this fungus does not cause serious problems for healthy people, but it can lead to severe infections in individuals with weakened immune systems. In this report, we discuss a rare case where a healthy person developed an infection after being exposed to a biopesticide containing this fungus.

Zinner syndrome: report of a case and whole exome sequencing.

Background: Zinner syndrome is a rare congenital malformation of the male genitourinary system, characterized by a triad: seminal vesicle cyst, unilateral renal agenesis, and ipsilateral ejaculatory duct obstruction. The etiology of this uncommon disease remains largely elusive; however, genetic mutations may contribute to its development. In this report, we present a case of symptomatic Zinner syndrome that was surgically treated, alongside an investigation into the potential genetic basis of the syndrome via whole exome sequencing.

Leveraging microbiome signatures to predict tumor immune microenvironment and prognosis of patients with endometrial carcinoma.

Recent studies suggest that the human microbiome influence tumor development. Endometrial carcinoma (EC) is the sixth most common malignancy in women. Recent research has demonstrated the microbes play a critical role in the development and metastasis of EC.

Proteogenomic characterization reveals tumorigenesis and progression of lung cancer manifested as subsolid nodules.

Lung adenocarcinoma (LUAD) radiologically displayed as subsolid nodules (SSNs) is prevalent. Nevertheless, the precise clinical management of SSNs necessitates a profound understanding of their tumorigenesis and progression. Here, we analyze 66 LUAD displayed as SSNs covering 3 histological stages including adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) by incorporating genomics, proteomics, phosphoproteomics and glycoproteomics.

Expert consensus on clinical genome sequencing interpretation and reporting.

Genome sequencing (GS) refers to a technology that comprehensively and systematically detects the DNA sequences of an individual's nuclear and mitochondrial genomes. It aims to identify genetic variants and investigate their roles in human health and disease progression. As an emerging diagnostic tool, GS offers significant support for clinical diagnosis due to its high throughput, accuracy, and comprehensiveness.

Gap-free genome assembly and comparative analysis reveal the evolution and lignin degradation mechanisms of Cylindrobasidium torrendii.

The Physalacriaceae family comprises numerous saprophytic edible and medicinal fungi with significant ecological and economic importance. However, the lack of high-quality genomic data has hindered systematic studies of this family. Here, we report the chromosome-level genome assembly of Cylindrobasidium torrendii, a species identified in China, using a combination of Illumina, PacBio HiFi, and Hi-C sequencing technologies.

Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy.

STING is an important DNA sensing machinery in initiating immune response, yet therapies targeting STING have shown poor outcomes in clinical trials. Here, we reveal that STING signaling induces PD-L1 tumor monocytes (Tu.Mons) that dominate the resistance against STING agonist therapy.

Multimodal integration of liquid biopsy and radiology for the noninvasive diagnosis of gallbladder cancer and benign disorders.

Gallbladder cancer (GBC) frequently mimics gallbladder benign lesions (GBBLs) in radiological images, leading to preoperative misdiagnoses. To address this challenge, we initiated a prospective, multicenter clinical trial (ChicCTR2100049249) and proposed a multimodal, non-invasive diagnostic model to distinguish GBC from GBBLs. A total of 301 patients diagnosed with gallbladder-occupying lesions (GBOLs) from 11 medical centers across 7 provinces in China were enrolled and divided into a discovery cohort and an independent external validation cohort.

Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis.

Cancer development involves the co-evolution of cancer cells and their surrounding microenvironment, yet the dynamics of this interaction within the physical architecture remains poorly understood. Here, we present a spatial transcriptomic map at single-cell resolution, encompassing 127 multi-stage fields of view from 43 patients, to chart the evolutionary trajectories of human esophageal squamous cell carcinoma (ESCC). By analyzing 6.

Effect of epidural labour analgesia on gastric emptying during labour: A prospective controlled study.

Background: Epidural analgesia is frequently used to alleviate labour pain, and dietary management during labour is of crucial importance. Therefore, this study investigates the impact of epidural analgesia for labour on gastric emptying in parturient women.

Methods: A total of 70 full-term parturient women were recruited and divided into two groups: the epidural analgesia group (LA, n = 35) and the non-epidural analgesia group (NA, n = 35).

Efficacy and safety of antithrombin or recombinant human thrombomodulin in the treatment of disseminated intravascular coagulation: A systematic review and meta-analysis.

Objective: Multiple organ damage is a hallmark of the highly lethal condition known as disseminated intravascular coagulation (DIC). The efficacy and safety of recombinant human soluble thrombomodulin (rhTM) and antithrombin (AT) in DIC is still debatable. Therefore, we used a fixed-effects model to conduct a comprehensive evaluation and meta-analysis to examine the safety and efficacy of AT or rhTM administration for treating DIC.

Treatment decision-making factors and sequencing in recurrent and/or metastatic squamous cell carcinoma of the head and neck.

Treatment options for patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) have evolved over the past decade and have helped improve survival outcomes for patients. Most national and regional guidelines recommend first-line therapy with an immune checkpoint inhibitor (with or without chemotherapy) or a cetuximab-based regimen, by assessment of expression levels of the biomarker programmed cell death-ligand 1 (PD-L1). However, patient- and tumor-specific factors, including the patient's age, comorbidities, performance status, and tumor burden, kinetics and spread also need to be considered to optimize treatment in the first line.

Origami-Based Flexible Robotic Grippers via Hard-Soft Coupled Multimaterial 3D Printing.

This study explores the design and performance of origami robotic grippers fabricated through hard-soft coupled multimaterial three-dimensional (3D) printing. We evaluate the impact of design parameters on the kinematic behavior and mechanical functionality of the gripper. A kinematic model is employed to characterize the reachable workspace and motion capabilities, revealing that variations in geometric parameters significantly influence the origami gripper's performance.

Nanoarchitectonics of High-Performance and Flexible n-Type Organic-Inorganic Composite Thermoelectric Fibers for Wearable Electronics.

Since most conductive polymers are -type, developing high-performance -type organic-inorganic composite thermoelectric (TE) fibers is a great challenge. Herein, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)-coated AgTe nanowires (PC-AgTe NWs) were prepared by a liquid-phase reaction using PEDOT:PSS-coated Te nanowires (PC-Te NWs) as templates, and the PEDOT:PSS/PC-AgTe NWs composite fibers were then prepared by wet spinning. As the content of PC-AgTe NWs increases, the composite fiber changes from -type to -type.

Advanced Logic Computing and Hybrid Crypto-Steganography for Molecular Information Coding Using Gold/Silver Nanoclusters.

In the domain of digital data exchange, ensuring information security is the supreme demand for data storage and transmission. Interlinking cryptographic techniques with steganographic principles can enhance data confidentiality. However, there have been no reports thus far to develop molecular platforms for hybrid crypto-steganography systems.

Coupled CFD-DEM simulation of progressive failure of tunnel face in sand.

Many studies have investigated tunnel face failure using the discrete element method (DEM). However, DEM simulations that incorporate water-soil interactions in tunnel face failure are still limited. In this study, the coupled CFD-DEM method is employed to simulate the progressive failure of the shield tunnel face in both saturated and dry sand.

Ambiently Dried Aerogel-Foam Composites with Gradient Pore Structure for Enhanced Sound Absorption.

Silica-based aerogels are widely regarded as promising sound-absorbing materials due to their low density and high specific surface area. However, their hard surface and small pores hinder sound wave penetration, resulting in a relatively poor sound absorption performance. To overcome this limitation, our study employs melamine foam (MF) as a scaffold to construct a gradient aerogel composite acoustic absorber.

Electroacupuncture delays the progression of juvenile collagen-induced arthritis via regulation NLRP3/ NF-κB signaling pathway -mediated pyroptosis and its influence on autophagy.

Background: Juvenile idiopathic arthritis (JIA) can lead to synovial inflammation. JIA is a chronic autoimmune inflammatory condition that primarily affects children. It is recognized as the most prevalent form of arthritis in the pediatric population and is associated with significant impairment and disability.

Efficacy and Safety of Third-Generation EGFR-TKIs Combined with Radiotherapy for Advanced NSCLC with Typical EGFR Mutations: A Retrospective Study.

Objective: To evaluate the efficacy and safety of third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in combination with radiotherapy (RT) for patients with advanced non-small cell lung cancer (NSCLC) harboring typical EGFR mutations.

Methods: Patients who received treatment with third-generation EGFR-TKIs alone or in combination with RT were retrospectively enrolled at a single center. The primary endpoint was progression-free survival (PFS).