Surface Organic Nanostructures Mediated by Extrinsic Components: from Assembly to Reaction.

Surface organic nanostructures demonstrate great potential across multidisciplinary fields ranging from molecular electronics to energy conversion and storage. In the regime of surface chemistry, their preparation generally relies on intrinsic components originally involved in the molecule-substrate systems to drive molecular assembly and reaction. The recent paradigm shift employs extrinsic components as functional mediators to precisely regulate nanostructure formation pathways and the resulting molecular nanostructures.

Monitoring Changes in the Levels of Newly Synthesized Proteins in Response to Nutlin-3 Treatment.

Developing methodological approaches for discovering novel pathways is a key challenge in the life science research. Biological pathways are regulated-in higher eukaryotes-by a vast diversity of linear peptide motifs that mediate combinatorial specificity in signal transduction pathways. The E3 ubiquitin ligase component (MDM2) is such a protein that interacts with target proteins containing linear motifs such as p53.

Ameliorative effect of Fagonia indica-coated chitosan nanoparticles on the ovulatory pattern in PCOS rat model.

Background: Polycystic ovarian syndrome (PCOS) with wide-range prevalence, affecting 5-18% of females of reproductive age, and its substantive role as a primary etiological factor in anovulatory infertility, with up to 80% of such cases attributed to this syndrome having particular significance.

Objectives: The current research delineates the outcomes of a meticulous inquiry into the efficacy of Fagonia indica-coated chitosan nanoparticles (FICNPs) in ameliorating the prevalent and clinically consequential PCOS in female Wistar rats.

Methodology: FICNPs were synthesized by using a methanolic extract of F.

Fecal microbiota transplantation restores gut microbiota diversity in children with active Crohn's disease: a prospective trial.

Background: Clinical data on oral fecal microbiota transplantation (FMT), a promising therapy for Crohn's disease (CD), are limited. Herein, we determined the short-term safety and feasibility of FMT for pediatric patients with active CD.

Methods: In this open-label, parallel-group, single-center prospective trial, patients with active CD were treated with oral FMT capsules combined with partial enteral nutrition (PEN) (80%).

Oxygen-delivery nanoparticles enhanced immunotherapy efficacy monitored by granzyme B PET imaging in malignant tumors.

Limited treatment response and inadequate monitoring methods stand firmly before successful immunotherapy. Recruiting and activating immune cells in the hypoxic tumor microenvironment is the key to reversing immune suppression and improving immunotherapy efficacy. In this study, biomimetic oxygen-delivering nanoparticles (CmPF) are engineered for homologous targeting and hypoxia alleviation within the tumor environment.

Application of family-centered care in cardiac surgery: a scoping review.

Background: Family-centered care (FCC) has been widely implemented in various medical settings, its application in cardiac surgery remains underexplored. Given the complexity of cardiac surgery and the significant impact on both patients and families, understanding FCC's role in this context is essential to improving patient outcomes and family well-being.

Objectives: To identify the current state of the application of FCC in the families of cardiac surgery.

Antiviral treatment for viral pneumonia: current drugs and natural compounds.

In recent years, viral pneumonia has become a significant challenge to global public health, particularly during the COVID-19 pandemic. Viral pneumonia can be caused by various viruses, including influenza virus, RSV, and adenovirus. These viruses trigger inflammatory responses by invading the respiratory epithelial cells, leading to lung damage.

Longitudinal cross-lagged association between posttraumatic stress disorder, post-traumatic growth, and deliberate rumination among healthcare staff 2 years after the COVID-19 pandemic in Hubei Province, China.

Background: Post-traumatic stress disorder (PTSD) and post-traumatic growth (PTG) are inspiratory areas of psychological research in which deliberate rumination has important implications. However, these relationships have not yet been assessed in the COVID-19 pandemic using longitudinal designs.

Methods: In this study, measures of PTSD, PTG, and deliberate rumination were collected from 2,292 healthcare staff members at two-time points six months apart in 2022-2023 from two general hospitals in Hubei Province, China.

Impact of celastrol on mitochondrial dynamics and proliferation in glioblastoma.

Background: Targeting mitochondrial dynamics offers promising strategies for treating glioblastoma multiforme. Celastrol has demonstrated therapeutic effects on various cancers, but its impact on mitochondrial dynamics in glioblastoma multiforme remains largely unknown. We studied the effects of Celastrol on mitochondrial dynamics, redox homeostasis, and the proliferation.

The impact of low-protein diet on residual renal function in dialysis patients: a systematic review and metaanalysis.

Objective: A low-protein diet is essential for the nutritional management of chronic kidney diseases as it can reduce renal burden. However, the effect of low-protein diets on dialysis patients compared to pre-dialysis patients remains unclear. This study aims to compare residual renal function among dialysis patients following a low-protein diet versus a normal diet, offering valuable insights into the optimal nutritional strategy for preserving residual renal function.

PRMT3 drives PD-L1-mediated immune escape through activating PDHK1-regulated glycolysis in hepatocellular carcinoma.

Aberrant expression of programmed death ligand-1 (PD-L1) facilitates tumor immune evasion. Protein arginine methyltransferase 3 (PRMT3), a member of type I PRMT family, mediates asymmetric dimethylarginine (ADMA) modification of various substrate proteins. This study investigates the role of PRMT3 in PD-L1-associated tumor immunosuppression in hepatocellular carcinoma (HCC).

Artificial Intelligence in Facial Measurement: A New Era of Symmetry and Proportions Analysis.

Background: Facial symmetry and proportions are key factors in aesthetic evaluations across fields like cosmetic surgery, dermatology, and facial recognition. Traditional measurement methods often rely on subjective analysis, making them prone to inconsistencies. The measure face ratio-F4CE app, an AI-driven tool, provides an innovative solution for precise and objective facial analysis.

Preoperative classification of urinary stones based on community detection.

In the treatment of urinary stones, surgical intervention is crucial. Urinary stones composition and type directly affect surgical planning. However, research on preoperative stone composition analysis is limited.

Relationship between systemic immune response index (SIRI) and COPD: a cross-sectional study based on NHANES 2007-2012.

Although the link between inflammation and chronic obstructive pulmonary disease (COPD) is increasingly recognized, the correlation between systemic immune response index (SIRI), a novel marker of inflammation, and COPD is unknown. This cross-sectional study used data from patients with complete lung function in NHANES 2007-2012 to explore the relationship between SIRI and COPD. We performed a series of statistical analyses on a total of 5056 participants, including multiple linear regression, smoothed curve fitting, ROC curve analysis, and subgroup analysis.

Cost-effectiveness of atezolizumab plus bevacizumab versus sorafenib as first-line therapy in unresectable hepatocellular carcinoma in the US and Chinese setting: a modelling comparison study.

Objective: Atezolizumab plus bevacizumab demonstrates a significant improvement in overall survival and progression-free survival compared with sorafenib in patients with unresectable hepatocellular carcinoma (HCC). The combined usage of these two medications could result in substantial consumption of resources, primarily due to their exceptionally high costs. The current study aims to evaluate the cost-effectiveness of atezolizumab plus bevacizumab as a first-line treatment for advanced HCC from the perspective of payers in developed and developing countries.

Traffic-related heavy metals exposure with serum uric acid and hyperuricemia in general Chinese urban adults: Roles of systemic inflammation.

The health effects of traffic-derived pollutants have gathered increasing concerns. Our objectives were to evaluate the associations of traffic-related heavy metal exposure with serum uric acid (SUA) and hyperuricemia and to explore the underlying mechanism. Traffic-related heavy metals (including zinc, iron, manganese, copper, lead, cadmium, antimony, and barium) and SUA were determined among 3909 community-based adults from the Wuhan-Zhuhai cohort.

Generative discovery of safer chemical alternatives using diffusion modeling: A case study in green solvent design for cyclohexane/benzene extractive distillation.

Over the past century, advancements in chemistry have significantly propelled human innovation, enhancing both industrial and consumer products. However, this rapid progression has resulted in chemical pollution increasingly surpassing planetary boundaries, as production and release rates have outpaced our monitoring capabilities. To catalyze more impactful efforts, this study transitions from traditional chemical assessment to inverse chemical design, introducing a generative graph latent diffusion model aimed at discovering safer alternatives.

Review of research advances in microbial sterilization technologies and applications in the built environment.

As globalization accelerates, microbial contamination in the built environment poses a major public health challenge. Especially since Corona Virus Disease 2019 (COVID-19), microbial sterilization technology has become a crucial research area for indoor air pollution control in order to create a hygienic and safe built environment. Based on this, the study reviews sterilization technologies in the built environment, focusing on the principles, efficiency and applicability, revealing advantages and limitations, and summarizing current research advances.

[The study of detection and etiology of delayed sensorineural hearing loss in children].

To investigate the detection of the age and pathway and the etiology of sensorineural hearing loss in children, and to guide the early diagnosis. A retrospective analysis was conducted on the children who passed neonatal hearing screening but were diagnosed with sensorineural hearing loss in our department from January 2019 to September 2022. The clinical characteristics of 66 children with complete medical history, audiology examination, imaging examination and genetic detection of hearing loss were studied.

[A case of adult temporal bone langerhans cell histiocytosis presenting as posterior canal dehiscence syndrome and literature review].

This report describes a case of adult temporal bone Langerhans cell histiocytosis（LCH） that presented as posterior canal dehiscence syndrome（PCDS）. The patient initially presented with vertigo, tinnitus, and hearing loss. Computed tomography（CT） revealed erosive changes in the mastoid and posterior semicircular canal.

Drp1 knockdown aggravates obesity-induced cardiac dysfunction and remodeling.

Obesity is an independent risk factor for heart failure with preserved ejection fraction (HFpEF). Dynamin related protein 1 (Drp1) is a key regulator of mitochondrial morphology, bioenergetics and quality control. The role of endogenous Drp1 in obesity induced HFpEF remains largely unknown.

Schwann cells secrete IGFBP5 to facilitate the growth of keloids.

Keloids (KD) are noncancerous fibroproliferative tumors exhibiting cancer-like traits, encompass aggressive unregulated growth, absence of natural regression, and a significantly high rate of recurrence. The precise molecular mechanisms underlying KD pathology remain poorly understood. In this study, we employed single-cell sequencing to examine the characteristics of cells in KD and normal scar (NS) tissue.

Severe asthma beyond bronchodilators: Emerging therapeutic approaches.

Asthma is characterized by reversible airway inflammation, obstruction, and structural remodeling, which lead to the eosinophils and lymphocytes accumulation at inflammation sites and the release of inflammatory cells, like mast cells and dendritic cells, from lungs' epithelial and smooth muscle cells that trigger the activation and release of cytokines and chemokines, attracting more cells and contributing to asthma development. Available pharmacological interventions, like bronchodilators and anti-inflammatory agents, are considered generally safe and effective to treat asthma, but many affected individuals with severe asthma still struggle with symptom control. This review highlights recent innovative therapies, such as chemoattractant receptor-homologous molecule expressed on Th2 cell (CRTH2) antagonists, S-nitrosoglutathione reductase (GSNOR) and phosphodiesterase (PDE) inhibitors, and other novel biological agents, which offer potential new strategies for managing severe asthma and may alter the disease's course.

Midkine, a novel MCP-1 activator mediated PM2.5-aggravated experimental pulmonary fibrosis.

Exposure to fine particulate matter (PM2.5) is associated with increased morbidity and mortality among patients with idiopathic pulmonary fibrosis (IPF). Pathological alterations in IPF typically originate in the subpleural regions of the lungs.

Decabromodiphenyl ethane exposure-mediated mitochondrial dysfunction drives oxeiptosis in placental trophoblasts and induces fetal growth restriction.

Decabromodiphenyl ethane (DBDPE), a newly emerging brominated flame retardant (BFR), has garnered increasing attention due to its high production volumes and widespread usage, prompting worries about its possible impacts on human well-being. Prior investigations have highlighted the substantial toxicity of DBDPE to the thyroid, liver, and cardiovascular systems, yet its effects on fetal growth and development remain inadequately understood. This investigation aims to elucidate the underlying mechanisms and consequences of DBDPE exposure on fetal growth and development through both in vivo and in vitro models.