CD16CD56 NK Cells: A Protective NK Cell Subset for Progression and Prognosis in Amyotrophic Lateral Sclerosis.

Amyotrophic lateral sclerosis (ALS) is a non-neuron-autonomous disease where peripheral immune dysregulation significantly impacts disease progression. However, the immunopathological mechanisms of natural killer (NK) cells in ALS remain largely unexplored. This study enrolled 241 ALS patients and 102 healthy controls (HC), analyzing lymphocyte subsets, including T cells, B cells, and NK cells.

Room-Temperature Synthesis of Carbon Nanochains via the Wurtz Reaction.

In the field of surface synthesis, various reactions driven by the catalytic effect of metal substrates, particularly the Ullmann reaction, have been thoroughly investigated. The Wurtz reaction facilitates the coupling of alkyl halides through the removal of halogen atoms with a low energy barrier on the surface; however, the preparation of novel carbon nanostructures via the Wurtz reaction has been scarcely reported. Here, we report the successful synthesis of ethyl-bridged binaphthyl molecular chains on Ag(111) at room temperature via the Wurtz reaction.

Socioeconomic Inequalities in PM Exposure and Local Source Contributions at Community Scales Using Hyper-Localized Taxi-Based Mobile Monitoring in Xi'an, China.

The relationship between the socioeconomic status (SES) and PM exposure is rather inconclusive. We employed taxi-based measurements with 30 m resolution to characterize PM exposure with local source contribution (PM adjusted concentration) discerned for 2019 winter and 2020 summer, in Xi'an. A big data set comprising ∼6 × 10 hourly PM measurements and SES data from ∼5000 communities was utilized to examine the socioeconomic inequalities in community-level PM exposure.

LncRNA-DANCR Promotes ESCC Progression and Function as ceRNA to Regulate DDIT3 Expression by Sponging microRNA-3193.

Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of cancer development and progression. Among them, Differentiation Antagonizing Non-Protein Coding RNA (DANCR) has been implicated in various malignancies, including esophageal squamous cell carcinoma (ESCC). This study explores the clinical characteristics, prognostic implications, functional roles, and molecular mechanisms of DANCR in ESCC.

Case Report: PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis) Syndrome With a Novel TNFAIP3 Mutation.

Background: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome has been considered as a childhood syndrome. Its etiopathogeny is unknown however, currently considered as auto-immune inflammatory disease. Recently, a few cases of adult-onset of PFAPA syndrome have been reported.

Exploring the exercise intensity equivalent to the anaerobic threshold in patients with acute myocardial infarction based on the 6-minute walk test distance.

Objective: This study aimed to evaluate the correlation between aerobic exercise intensity based on the 6 min walk test (6MWT) and the anaerobic threshold (AT)-based equivalent in patients with acute myocardial infarction (AMI). The feasibility of using the 6MWT for exercise prescription in primary care settings was also investigated.

Methods: A retrospective analysis was conducted on data from AMI patients, including statistics on all values of the cardiopulmonary exercise test and 6MWT parameters.

Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China.

Background: As the population in China rapidly ages, the prevalence of mild cognitive impairment (MCI) is increasing considerably. However, the causes of MCI vary. The continued lack of understanding of the various subtypes of MCI impedes the implementation of effective measures to reduce the risk of advancing to more severe cognitive diseases.

Multifunctional hydrogel loaded with 4-octyl itaconate and exosomes to induce bone regeneration for diabetic infected bone defect via Keap1-Nrf2 pathway.

Diabetic infected bone defect remains a great challenge in clinical practice, with delayed healing characterized by bacterial infection and cellular disfunction caused by oxidative stress. Hence, a novel self-healing multifunctional Ag@PEG-4OI/EXO hydrogel is introduced for improving healing of diabetic infected bone defect. 4-octyl itaconate, a derivative of the metabolite itaconate, has been proved that which performs antioxidant and mitochondria-protected properties.

Research progress of T cells in cholangiocarcinoma.

Cholangiocarcinoma (CCA), a malignant tumor, is typically challenging to detect early and often results in a poor prognosis. In recent years, research interest has grown in the potential application of immunotherapy for CCA treatment. T cells, as a crucial component of the immune system, play a significant role in immune surveillance and therapy for cholangiocarcinoma.

SNS‑032 combined with decitabine induces caspase‑3/gasdermin E‑dependent pyroptosis in breast cancer cells.

SNS-032 is a synthetic compound that specifically inhibits cyclin-dependent kinases 2, 7 and 9. Its primary anticancer activity involves cell cycle arrest, which prevents tumor cell growth. However, there are limited reports on whether SNS-032 induces pyroptosis, a novel inflammation-mediated programmed cell death pathway in breast cancer (BC).

Investigation of the Impact Factors and Efficacy of N-Butylphthalide (NBP) on Functional Outcomes Following Mechanical Thrombectomy in Stroke Patients.

Background: Ischemic stroke was a major cause of mortality and disability worldwide. Mechanical thrombectomy (MT) has improved acute ischemic stroke treatment by restoring blood flow in large vessel occlusions. Yet, reperfusion injury remains a challenge, necessitating adjunctive neuroprotective strategies to enhance recovery.

Relating Solute-Membrane Electrostatic Interactions to Solute Permeability in Reverse Osmosis Membranes.

Despite the widespread use of reverse osmosis (RO) membranes in water desalination, the role of solute-membrane interactions in solute transport remains complex and relatively not well understood. This study elucidates the relationship between solute-membrane electrostatic interactions and solute permeability in RO membranes. The transport of salt and neutral molecules through charged polyamide (PA) and uncharged cellulose triacetate (CTA) RO membranes was examined.

p53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer.

Background: Gastric cancer is one of the most prevalent malignant tumors within the digestive system, and ferroptosis playing a crucial role in its progression. Glutathione peroxidase 4 (GPX4), a key negative regulator of ferroptosis, is highly expressed in gastric cancer and contributes to tumor growth. Targeting the regulation of GPX4 has emerged as a promising approach to induce ferroptosis and develop effective therapy for gastric cancer.

Post-marketing safety of elacestrant in breast cancer: a pharmacovigilance investigation using the FDA adverse event reporting system.

Background: Recently, the US Food and Drug Administration approved a new oral selective estrogen receptor downregulator for breast cancer, namely, elacestrant (Orserdu). This study aimed to analyze the signals of adverse events (AEs) within the introduction of elacestrant to the market using the FDA Adverse Event Reporting System (FAERS) database.

Methods: Reports on the AEs of elacestrant after its marketing were obtained from the FAERS database.

Efficacy and safety of gastrodin in preventing postoperative delirium following cardiac surgery: a randomized placebo controlled clinical trial.

Background: Delirium and postoperative cognitive dysfunction (POCD) are common complications post-cardiac surgery, yet no specific medical intervention is currently recommended for prevention. This study aimed to evaluate the efficacy of gastrodin infusion in preventing delirium and POCD in critically ill patients following cardiac surgery.

Material And Methods: A double-blind, randomized, placebo-controlled trial was conducted on patients aged 18-75, scheduled for coronary artery bypass grafting (CABG) surgery, with or without valve replacement.

Beyond the itch: the complex interplay of immune, neurological, and psychological factors in chronic urticaria.

Chronic urticaria (CU) arises from a multifaceted interplay of immunological, neurological, and psychological components. Immune dysregulation, mediated through both immunoglobulin E (IgE)-dependent and IgE-independent pathways, plays a pivotal role in CU pathogenesis, involving key effector cells such as mast cells (MCs), basophils, and eosinophils. This dysregulation culminates in the release of histamine, prostaglandins, and other mediators, which precipitate pruritus.

Mitochondria-targeted nanovesicles for ursodeoxycholic acid delivery to combat neurodegeneration by ameliorating mitochondrial dysfunction.

Mitochondria are pivotal in sustaining oxidative balance and metabolic activity within neurons. It is well-established that mitochondrial dysfunction constitutes a fundamental pathogenic mechanism in neurodegeneration, especially in the context of Parkinson's disease (PD), this represents a promising target for therapeutic intervention. Ursodeoxycholic acid (UDCA), a clinical drug used for liver disease, possesses antioxidant and mitochondrial repair properties.

Psychometric properties of the Chinese version of the Quiet Quitting Scale.

Background: The phenomenon of quiet quitting has attracted considerable attention within the nursing community. Elevated quiet quitting levels can weaken the work environment, reducing healthcare efficiency and quality. However, appropriate assessment tools to measure this phenomenon remain unavailable in China.

Can some algorithms of machine learning identify osteoporosis patients after training and testing some clinical information about patients?

Objective: This study was designed to establish a diagnostic model for osteoporosis by collecting clinical information from patients with and without osteoporosis. Various machine learning algorithms were employed for training and testing the model, evaluating its performance, and conducting validations to explore the most suitable machine learning algorithm.

Methods: Clinical information, including demographic data, examination results, medical history, and laboratory test results, was collected from inpatients with and without osteoporosis.

Spontaneous psoas hematoma following posterior lumbar fusion surgery: a mini literature review.

Background: Spontaneous psoas hematoma is a very rare clinical entity, and the pathogenesis and pathologic mechanisms of spontaneous psoas hematoma remain unclear, thus, it is of great value to explore.

Case Presentation: We encountered a patient who developed femoral nerve paralysis due to psoas muscle hematoma following posterior lumbar fusion surgery. A 69-year-old female with lumbar spinal canal stenosis underwent posterior lumbar fusion at the L3-4 and L4-5 levels.

Finite element analysis of retrograde superior ramus screw of pubis for the treament of pelvic anterior ring fracture.

Background: Retrograde superior ramus screw of pubis (SRSP) is a new kind of pelvic minimally invasive internal fixation apparatus developed by our team. The purpose of this study was to analyze the biomechanical stability of this new minimally invasive pelvic internal fixation device, and to provide this new device with theoretical basis for clinical application.

Methods: The Tile C1.

Prognostic value of tumor deposits and positive lymph nodes in colorectal cancer surgery: improved staging for long-term prognosis.

Background: To evaluate the prognostic value of the presence and number of tumor deposits (TDs) and the combination of TDs and number of positive lymph nodes (PLNs) in patients undergoing colorectal cancer (CRC) surgery, and to modify N staging.

Method: The clinical data of 1470 patients with stage I-IV CRC who underwent surgery in Wuhan Union Hospital from February 2014 to May 2018 were collected. The optimal cutoff value for TD + PLNs was obtained using X-tile software, and patients were regrouped accordingly.

Deep cutaneous fungal infection in an immunocompetent individual caused by a biological pesticide: a rare case report.

Background: Purpureocillium lilacinum is a type of fungus that is found all over the world and is known for its ability to help control pests, especially those that harm plants. Generally, this fungus does not cause serious problems for healthy people, but it can lead to severe infections in individuals with weakened immune systems. In this report, we discuss a rare case where a healthy person developed an infection after being exposed to a biopesticide containing this fungus.