8 results match your criteria: "Tongji Medical College of Huazhong University of Science and Technology. Electronic address: shtu@tjh.tjmu.edu.cn.[Affiliation]"
Wutou decoction attenuates rheumatoid arthritis in rats through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway.
J Ethnopharmacol
January 2025
Department of Integrated Chinese Traditional and Western Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, China. Electronic address:
Article Synopsis
- Traditional Chinese medicine uses Wutou Decoction (WTD) for arthritis, and recent studies suggest it might help alleviate rheumatoid arthritis (RA), but its mechanisms are not fully understood.
- This study tested WTD's effects on collagen-induced arthritis in rats, focusing on the role of SIRT1 and how it interacts with the HMGB1/NF-κB pathway to exert antiarthritic effects.
- Results showed that WTD reduces arthritis symptoms in rats and inflammation-related substances while modulating immune responses, indicating its potential as a therapeutic option for RA through specific molecular pathways.
Demethylzeylasteral ameliorates podocyte damage in murine lupus by inhibiting inflammation and enhancing autophagy.
Phytomedicine
November 2024
Department of Integrated Chinese Traditional and Western Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology. Electronic address:
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multiorgan and tissue involvement. Lupus nephritis (LN), an inflammatory condition of the kidneys associated with SLE, represents a significant cause of morbidity and mortality in SLE patients. Current immunosuppressive therapies for LN have limited efficacy and can lead to significant side effects.
View Article and Find Full Text PDFWutou decoction alleviates arthritis inflammation in CIA mice by regulating Treg cell stability and Treg/Th17 balance via the JAK2/STAT3 pathway.
J Ethnopharmacol
November 2024
Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Article Synopsis
- Wutou Decoction (WTD) is a traditional Chinese medicine that shows promise in treating rheumatoid arthritis (RA) by addressing issues related to Treg cell stability and CD4 T cell subset imbalances, which are critical in RA progression.!* -
- The study aimed to investigate how WTD influences Treg cells and CD4 T cell subsets through both in vivo (in mice) and in vitro (in lab) experiments, measuring various therapeutic effects and immune responses.!* -
- Results indicated that WTD effectively reduced joint inflammation and serum IL-6 levels in collagen-induced arthritis mice, while also improving their overall health indicators and inhibiting the activation of harmful T cell pathways.!*
Mechanisms of NLRP3 inflammasome in rheumatoid arthritis and osteoarthritis and the effects of traditional Chinese medicine.
J Ethnopharmacol
March 2024
Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Article Synopsis
- Traditional Chinese medicines (TCMs) have been found to help alleviate rheumatoid arthritis (RA) and osteoarthritis (OA) by regulating the NLRP3 inflammasome, which plays a significant role in inflammation.
- The study aims to review existing literature about the NLRP3 inflammasome's involvement in RA and OA and the ways TCMs interact with this inflammasome to provide therapeutic benefits.
- A total of 35 TCMs were identified for RA treatment and 23 for OA that specifically target the NLRP3 inflammasome, showcasing the potential of both traditional prescriptions and extracts from Chinese herbs in managing these conditions.
Wutou decoction attenuates the synovial inflammation of collagen-induced arthritis rats via regulating macrophage M1/M2 type polarization.
J Ethnopharmacol
January 2023
Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Ethnopharmacological Relevance: Thousands of years of clinical practice in the treatment of joint-related diseases support the efficacy and safety of Wutou decoction (WTD). Nevertheless, the lack of pharmacological evidence and unclear mechanisms make it difficult for WTD to become a recognized complementary therapy for the treatment of rheumatoid arthritis (RA).
Aim Of The Study: This study aimed to investigate the effect of WTD against synovial inflammation in RA and whether this effect depends on the regulation of macrophage polarization.
Positive effects of Lianhuaqingwen granules in COVID-19 patients: A retrospective study of 248 cases.
J Ethnopharmacol
October 2021
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Ethnopharmacological Relevance: Lianhuaqingwen (LHQW) is a Chinese medicine, developed from appropriate addition and reduction of combined traditional Chinese medicine (TCM) Yinqiao San and Maxing Shigan decoction. LHQW has been used in routine influenza treatment for decades and plays a role in a broad-spectrum therapy on various influenza viruses.
Aims Of The Study: The therapeutic effects of LHQW in coronavirus disease 2019 (COVID-19) have not been fully elucidated.
Quercetin-mediated SIRT1 activation attenuates collagen-induced mice arthritis.
J Ethnopharmacol
October 2021
Department of Integrated Chinese Traditional and Western Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, China. Electronic address:
Ethnopharmacological Relevance: Herba taxilli (HT, Sangjisheng in Chinese), which is composed of the dried stems and leaves of Taxillus chinensis (DC.) Danser, has been commonly used to treat inflammation and arthritis in traditional Chinese medicine (TCM). Quercetin (Que) is a major active flavonoid component isolated from HT and is one of the quality control indexes of HT.
View Article and Find Full Text PDFDecipher manifestations and Treg /Th17 imbalance in multi-staging rheumatoid arthritis and correlation with TSDR/RORC methylation.
Mol Immunol
November 2020
Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic address:
T regulatory (Treg)/T-helper (Th) 17 imbalance has been shown to integrate with epigenetics to result in the development of autoimmune diseases. We aim to investigate the influence of disease staging on Treg/Th17 cells and whether the aberrant DNA methylation is implicated in the development of rheumatoid arthritis (RA). By recruiting 65 patients with multi-staging RA and 20 healthy controls (HC), we found that patients with active RA exhibited relative lymphopenia and higher WBC, neutrophils, and PLT.
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