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Up-regulation of VEGF and its receptor in refractory leukemia cells.
Int J Clin Exp Pathol
April 2016
Department of Hematology, Tongji Hospital of Tongji University 389 Xincun Road, Shanghai 200065, China.
Objective: To analyze the causative mechanisms in refractory leukemia cells.
Methods: Vascular endothelial growth factor (VEGF) blood plasma concentrations in 35 de novo, 6 relapse, 20 remission leukemia patients and 10 healthy kids were determined via ELISA analyses. Transcription levels of the VEGF receptors (VEGFR) Fms-like tyrosine kinase-1 (Flt-1) and kinase-domain insert containing receptor (KDR) were determined in participants' leucocytes with RT-PCR.