[Effect of Rongshi granule on renal stone formation and osteopontin expression in rat urolithiasis model].

Objective: To investigate the effect of Rongshi granule on osteopontin(OPN) expression.

Method: The urlisthiasis rats were induced by ethylene glycol (EG) and ammonium chloride, the control group rats were non-treated, and the Rongshi granule groups (low-dose group, middle-dose group and high-dose group) were administered Rongshi granule in addition to EG and ammonium chloride in 21 days. Pooled 24 h urine samples from each group were collected weekly with the use of metabolic cages, the concentration of uric calcium and oxalic acid were respectively measured by EDTA and photoelectric colorimetric method.