312 results match your criteria: "Tokyo Shinjuku Medical Center[Affiliation]"
Predictors for hemostatic thrombin-gelatin matrix usage in spine surgery: a multicenter observational study.
BMC Musculoskelet Disord
April 2023
Department of Orthopaedic Surgery, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Study Design: A prospective cohort study.
Objectives: Thrombin-gelatin matrix (TGM) is a rapid and potent hemostatic agent, but it has some limitations, including the cost and its preparation time. The purpose of this study was to investigate the current trend in the use of TGM and to identify the predictors for TGM usage in order to ensure its proper use and optimized resource allocation.
Article Synopsis
- The study investigates the association between thrombosis and clinical outcomes in hospitalized COVID-19 patients in Japan, using data from the CLOT-COVID study.
- Patients with thrombosis (55 individuals) experienced significantly higher mortality (23.6% vs. 5.1%) and major bleeding events (23.6% vs. 1.6%) compared to those without thrombosis (2839 individuals).
- Independent risk factors for thrombosis included being male, having elevated D-dimer levels on admission, and severe COVID-19 status, which could help guide treatment decisions for these patients.
Specific COVID-19 risk behaviors and the preventive effect of personal protective equipment among healthcare workers in Japan.
Glob Health Med
February 2023
Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.
Article Synopsis
- A case-control study was conducted to assess COVID-19 infection risk among healthcare workers, collecting data on demographics, contact behaviors, and protective equipment usage.
- Out of 1,899 participants, 161 (8.5%) were found to be seropositive, with physical contact and aerosol-generating procedures significantly increasing risk.
- The use of goggles and N95 masks effectively reduced the risk of infection, and seroprevalence was notably higher in outbreak wards compared to COVID-19 dedicated wards.
Clinical and Genetic Characteristics of Patients with Moyamoya Disease who Experienced Both Ischemic and Hemorrhagic Events.
World Neurosurg
April 2023
Department of Neurosurgery, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Objective: Cerebrovascular events in moyamoya disease are mainly classified into ischemic or hemorrhagic onset. It is rare for one patient to develop both ischemia and hemorrhage in moyamoya disease; detailed clinical course and genetic characteristics of such patients have not been elucidated. We aimed to clarify the clinical features of patients with both ischemic and hemorrhagic cerebrovascular events.
View Article and Find Full Text PDFDeep Optic Nerve Head Structures Associated With Increasing Axial Length in Healthy Myopic Eyes of Moderate Axial Length.
Am J Ophthalmol
May 2023
Hamilton Glaucoma Center, Shiley Eye Institute (L.M.Z., R.N.W.), and the Viterbi Family Department of Ophthalmology (L.M.Z., R.N.W.), University of California San Diego, La Jolla, California, USA.
Purpose: To elucidate which swept-source optical coherence tomography (OCT)-derived optic nerve head (ONH) parameters are associated with longer axial length (AXL) in healthy myopic eyes.
Design: Prospective cross-sectional observational study.
Methods: Two hundred eleven healthy eyes of 140 participants (96 emmetropic-mild myopic [AXL: 22.
A Retrospective Study of Patients Undergoing Palliative Radiotherapy for Airway Obstruction due to Lung Cancer.
Cancer Diagn Progn
January 2023
Department of Radiation Oncology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Background/aim: In advanced stage lung cancer, bulky tumors can cause serious symptoms such as malignant airway obstruction (MAO). Prompt response to airway obstruction might be essential to improve quality of life and prolong life expectancy. Palliative external beam radiotherapy (EBRT) is a less invasive and highly safe treatment method that can alleviate symptoms and at the same time treat lung cancer.
View Article and Find Full Text PDFArticle Synopsis
- The study focused on understanding the use of prophylactic anticoagulation for COVID-19 patients in Japan, highlighting its clinical management strategies.
- Conducted as a multicenter observational study, it involved 2,894 hospitalized patients, ultimately analyzing 2,889 patients based on their anticoagulation treatment.
- Results revealed that the severity of COVID-19 at admission strongly influenced the use of pharmacological thromboprophylaxis and therapeutic dosing, particularly in patients with comorbidities.
Tumor Location and a Tumor Volume over 2.8 cc Predict the Prognosis for Japanese Localized Prostate Cancer.
Cancers (Basel)
November 2022
Department of Urology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Article Synopsis
- The study aimed to assess how tumor volume and location impact the prognosis of prostate cancer patients following radical prostatectomy.
- Researchers analyzed data from 557 patients and found that a tumor volume of 2.8 cc or greater, along with tumors located in the posterior area or peripheral zone, were significant predictors of biochemical recurrence (BCR).
- A new risk model was developed based on these findings, indicating that patients with high-risk factors had worse progression-free survival compared to others, particularly in low- to intermediate-risk groups.
A Telemedicine Approach for Monitoring COPD: A Prospective Feasibility and Acceptability Cohort Study.
Int J Chron Obstruct Pulmon Dis
November 2022
Department of Pulmonary Medicine, Fukushima Medical University, Fukushima, Japan.
Background: Telemedicine may help the detection of symptom worsening in patients with chronic obstructive pulmonary disease (COPD), potentially resulting in improved outcomes. This study aimed to determine the feasibility and acceptability of telemedicine among patients with COPD and physicians and facility staff in Japan.
Methods: This was a 52-week multicenter, prospective, single-arm, feasibility and acceptability cohort study of Japanese patients ≥40 years of age with COPD or asthma-COPD overlap.
Background: Reports of mortality-associated risk factors in patients with the novel coronavirus disease 2019 (COVID-19) are limited.
Methods: We evaluated the clinical features that were associated with mortality among patients who died during hospitalization (n = 158) and those who were alive at discharge (n = 2,736) from the large-scale, multicenter, retrospective, observational cohort CLOT-COVID study, which enrolled consecutively hospitalized COVID-19 patients from 16 centers in Japan from April to September 2021. Data from 2,894 hospitalized COVID-19 participants of the CLOT-COVID study were analyzed in this study.
Successful radiofrequency ablation of liver metastases from prostate cancer.
IJU Case Rep
November 2022
Department of Urology, Pathology, Gastroenterology Japan Community Health-Care Organization Tokyo Shinjuku Medical Center Tokyo Japan.
Introduction: Patients with liver metastases from prostate cancer show poor prognosis. We performed metastases-directed therapy using radiofrequency ablation of liver metastases in an attempt to improve the prognosis in a patient with metastatic prostate cancer.
Case Presentation: We present the case of a 66-year-old man who was treated for metastatic castration-resistant prostate cancer.
A Propensity Score-matched Analysis of Clinical Outcomes Between Single-level and Multilevel Intervertebral Decompression for Cervical Radiculopathy.
Spine (Phila Pa 1976)
February 2023
Department of Orthopaedic Surgery, the University of Tokyo, Tokyo, Japan.
Study Design: Retrospective multicenter study with propensity score matching.
Objective: To compare the clinical outcomes of single-level and multilevel intervertebral decompression for cervical degenerative radiculopathy.
Summary Of Background Data: In patients with cervical radiculopathy, physical examination findings are sometimes inconsistent with imaging data.
The relationship between preoperative Goutallier stage and retear rates following posterosuperior rotator cuff repair: a systematic review.
J Shoulder Elbow Surg
February 2023
Section of Orthopaedic Surgery, Department of Surgery, University of Calgary, Calgary, AB, Canada. Electronic address:
Background: An association between higher preoperative Goutallier stage and higher retear rates following primary rotator cuff repairs has been previously reported. However, there are few reviews which have described clear retear rates for each repaired tendon classified according to preoperative Goutallier stage. The purpose of this study was therefore to systematically review the literature on the relationship between preoperative Goutallier stage and retear rates and provide predictable retear rates following primary repair of posterosuperior rotator cuff tears.
View Article and Find Full Text PDFFactors associated with low prevalence of Fuchs' uveitis syndrome in Japan.
Front Med (Lausanne)
September 2022
Department of Ophthalmology, National Defense Medical College, Tokorozawa, Japan.
Article Synopsis
- The study aimed to investigate the low prevalence of Fuchs' uveitis syndrome (FUS) in Japan by reviewing medical records of 160 patients diagnosed with the condition at uveitis specialty facilities.
- Results showed that a significant number of patients were referred for idiopathic uveitis, cataracts, and glaucoma, with most patients experiencing unilateral symptoms and common findings like anterior inflammation and keratic precipitates.
- The conclusion suggests that the low prevalence of FUS in Japan may be due to misdiagnosis as milder conditions, affecting timely recognition and treatment of the syndrome.
Surgical outcomes between posterior decompression alone and posterior decompression with fusion surgery among patients with Meyerding grade 2 degenerative spondylolisthesis: a multicenter cohort study.
BMC Musculoskelet Disord
October 2022
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-Ku, 113-8655, Tokyo, Japan.
Background: Whether lumbar decompression with fusion surgery is effective against Meyerding grade 2 degenerative spondylolisthesis (DS) is unknown. Therefore, the current study aimed to compare the surgical outcomes between posterior decompression alone and posterior decompression with fusion surgery among patients with grade 2 DS with central canal stenosis.
Methods: This retrospective cohort study included prospectively registered patients (n = 3863) who underwent surgery for degenerative lumbar spinal canal stenosis at nine high-volume spine centers from April 2017 to July 2019.
Deep Learning for Bone Mineral Density and T-Score Prediction from Chest X-rays: A Multicenter Study.
Biomedicines
September 2022
Department of Orthopaedics Surgery, Hyogo Prefectural Kakogawa Medical Center, Kakogawa 675-0003, Japan.
Article Synopsis
- - The study addresses the growing issue of inadequate diagnosis and treatment for osteoporosis by developing a deep learning model that predicts bone mineral density (BMD) and T-score from chest X-rays, which are widely used and affordable imaging methods.
- - Using data from patients who had both DXA scans and chest X-rays, the model was trained through ensemble learning considering factors like age and sex, achieving notable correlation coefficients for BMD prediction (hip = 0.75, lumbar spine = 0.63).
- - The model demonstrated effective performance in predicting osteoporosis diagnoses with area under the curve scores for T-scores of 0.89 for normal, 0.70 for osteopenia, and 0.84 for osteoporosis, suggesting
Background: The coronavirus disease 2019 (COVID-19) causes extensive coagulopathy and a potential benefit of anticoagulation therapy has been documented for prevention of thromboembolic events. Bleeding events has also been reported as a notable complication; whereas, the incidence, risks, and clinical impact of bleeding remain unclear.
Method: The CLOT-COVID Study was a nationwide, retrospective, multicenter cohort study on consecutive hospitalized patients with COVID-19 in Japan between April 2021 and September 2021.
Article Synopsis
- Obesity's impact on COVID-19 severity and thrombosis risk was explored in the CLOT-COVID study, involving 2,690 hospitalized patients in Japan from April to September 2021.
- The study found that patients with obesity had more severe COVID-19 symptoms at admission and a higher risk for serious outcomes (like mechanical ventilation) but no significant difference in thrombosis rates compared to non-obese patients.
- Overall, while obesity did not significantly increase the risk of thrombosis, it was linked to worsened COVID-19 severity and worse hospitalization outcomes.
Safety and Efficacy of Carbon-Ion Radiotherapy for Elderly Patients with High-Risk Prostate Cancer.
Cancers (Basel)
August 2022
QST Hospital, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
Carbon-ion radiotherapy (CIRT) is a high-dose intensive treatment, whose safety and efficacy have been proven for prostate cancer. This study aims to evaluate the outcomes of CIRT in elderly patients with prostate cancer. Patients aged 75 years or above at the initiation of CIRT were designated as the elderly group, and younger than 75 years as the young group.
View Article and Find Full Text PDFReasons and risk factors for discontinuation of treatment with any biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: A long-term observational study.
Mod Rheumatol
August 2023
Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Objectives: Patients with rheumatoid arthritis (RA) usually switch to a second biological disease-modifying antirheumatic drugs (bDMARDs) when the first has proven to be ineffective, although some may discontinue bDMARDs treatment altogether. We investigated the total rate of bDMARDs retention and the risk of bDMARDs discontinuation in patients with RA.
Methods: The study included 564 patients with RA who started bDMARDs treatment before 2008 (<65 years old, n = 413; ≥65, n = 151).
Aim: There is scarce data on the impact of age on clinical outcomes in patients with coronavirus disease 2019 (COVID-19).
Method: The CLOT-COVID Study was a retrospective, multicenter cohort study enrolling 2894 consecutive hospitalized patients with COVID-19 among 16 centers in Japan from April 2021 to September 2021. We divided the entire cohort into five groups according to age strata; -19, 20-39, 40-59, 60-79, and 80- years.
Comparison of the medical costs between active surveillance and other treatments for early prostate cancer in Japan using data from the PRIAS-JAPAN study.
Int J Urol
November 2022
Department of Urology, Faculty of Medicine, Kagawa University, Kita-gun, Japan.
Article Synopsis
- - The study aims to compare the medical costs associated with active surveillance versus treatments like robot-assisted laparoscopic prostatectomy, brachytherapy, radiation therapy, and hormone therapy for low-risk prostate cancer.
- - An analysis of costs over the first five years for various therapies showed that active surveillance is significantly cheaper, with total costs coming to $1.65 million compared to much higher costs for other treatments (e.g., $14 million for surgery).
- - The findings suggest that if more patients (50% or 100%) chose active surveillance initially, up to $13.8 million could be saved in total treatment costs, highlighting the potential for cost savings in expanding this approach.
Graft Healing Is More Important Than Graft Technique: Superior Capsular Reconstruction Versus Bridging Grafts-A Prospective Randomized Controlled Trial.
Arthroscopy
December 2022
Department of Surgery, Section of Orthopaedic Surgery, McCaig Institute for Bone and Joint Health, University of Calgary; Calgary, Alberta, Canada. Electronic address:
Purpose: To compare superior capsular reconstruction (SCR) versus bridging graft (BG) for massive irreparable rotator cuff tears (RCTs).
Methods: A prospective double-blind randomized study was conducted to compare SCR versus BG for massive irreparable RCTs. Fifty patients (mean age: 60.
Extension contracture stiff knee in haemophilia: Surgical timing and procedure for total knee arthroplasty.
Mod Rheumatol
July 2023
Department of Joint Surgery, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Introduction: Total knee arthroplasty (TKA) for a stiff knee of patients with haemophilia (PWH) represents a challenge for orthopaedic surgeons for the difficulties of exposing the knee and high complication rate compared to a flexible knee.
Aim: To optimize the surgical exposure in primary TKA for PWH and to propose a threshold angle of extension contracture in treating haemophilic knee joints, retrospectively.
Methods: Sixty-seven primary TKAs for PWH (mean age, 48 years) were performed, and incisional approaches to joint were standard (58 cases) and V-Y quadricepsplasty (V-Y) (9 cases).
Background: The worsening of coronavirus disease 2019 (COVID-19) severity is a critical issue in current clinical settings and may be associated with the development of thrombosis.
Methods and results: This study used patient data obtained in the CLOT-COVID study, a retrospective multicenter cohort study. The demographics of patients with moderate COVID-19 on admission with and without worsened severity during hospitalization were compared and predictors were identified.