10 results match your criteria: "Tokyo Metropolitan Tama-Hokubu Medical Center[Affiliation]"
Tissue degrading and remodelling molecules in giant cell arteritis.
Rheumatology (Oxford)
January 2025
Research Center for Genome & Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Objectives: GCA is a granulomatous vasculitis affecting large vessels, leading to intimal occlusion accompanied by the accumulation of myofibroblasts. Histopathologically, GCA is characterized by destruction of the tunica media and hypertrophy of the intima with invasion of activated CD4+ T cells, macrophages and multinucleated giant cells (MNGCs). Despite these well-defined histopathological features, the molecular pathology of GCA has largely remained elusive.
View Article and Find Full Text PDFFrequency and severity of hyponatremia in healthy children with acute illness.
Pediatr Nephrol
March 2025
Department of Nephrology and Rheumatology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan.
Article Synopsis
- Hyponatremia is a condition marked by low sodium levels and can occur during the acute phase of many illnesses, but its prevalence and severity in various medical situations is not fully understood.
- A study at Tokyo Metropolitan Children's Medical Center reviewed 2,717 urgent pediatric admissions and found that 260 (13.8%) had hyponatremia, with type 1 diabetes being the most common associated condition (69%).
- The research highlighted significant hyponatremia in conditions like Kawasaki disease and acute infectious encephalopathy, but noted that conditions like acute bronchial asthma or fractures rarely showed low sodium levels upon arrival.
Actinotignum schaalii Can Cause Bacteremia in Children Without Urogenital Abnormalities: A Case Report.
Pediatr Infect Dis J
September 2024
Department of Pediatrics, Tokyo Metropolitan Tama-Hokubu Medical Center, Higashimurayama, Tokyo, Japan.
We describe the case of a 66-year-old man with an anastomotic fistula after rectal surgery, which was treated colonoscopically using polyglycolic acid sheets and fibrin glue. Polyglycolic acid sheets and fibrin glue have been used in thoracic surgery and otolaryngology to reinforce sutures and prevent air leakage. There have been recent reports of their use in endoscopic surgery for the closure of intraoperative perforations after endoscopic submucosal dissection and for fistula closure after upper gastrointestinal tract surgery.
View Article and Find Full Text PDFSimple and practical formulas for stage 1 hypertension reference values in children.
Acta Paediatr
June 2024
Department of Pediatric Nephrology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya City, Aichi, Japan.
Usefulness of BioFire Filmarray Meningitis/Encephalitis Panel for Diagnosis of Human Parechovirus Infection in Infants and Identification of Local Outbreaks.
Pediatr Infect Dis J
January 2024
Department of Pediatrics, Tokyo Metropolitan Tama-Hokubu Medical Center, Higashimurayama, Tokyo, Japan.
Association of Yersinia Infection With Kawasaki Disease: A Prospective Multicenter Cohort Study.
Pediatr Infect Dis J
December 2023
Clinical Research Support Center, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Background: Yersinia infection is known to present with Kawasaki disease (KD)-like symptoms although differentiating the 2 has been a challenge. The present study aimed to describe the clinical characteristics and prevalence of Yersinia infection presenting with KD-like symptoms.
Methods: The present, prospective, multicenter study enrolled patients who received a diagnosis of KD between January 2021 and January 2022 at 2 hospitals in Tokyo.
Association of Social Isolation and Loneliness With Chronic Low Back Pain Among Older Adults: A Cross-sectional Study From Japan Gerontological Evaluation Study (JAGES).
J Epidemiol
June 2024
Department of Social Science, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology.
Background: Per the biopsychosocial model, pain, especially chronic low back pain, which often presents with nonspecific pain, requires a comprehensive approach involving social factors. However, the association of social factors, including social isolation and loneliness, with this condition remains unclear. This study examined the cross-sectional association of social isolation and loneliness with chronic low back pain among older adults.
View Article and Find Full Text PDF[Multiple extramedullary plasmacytomas responding to a reduced dose of carfilzomib following drug-induced thrombotic microangiopathy].
Rinsho Ketsueki
January 2023
Department of Hematology, Tokyo Metropolitan Hospital Organization Tokyo Metropolitan Tama-Hokubu Medical Center.
Article Synopsis
- A 79-year-old man with primary plasma cell leukemia experienced multiple extramedullary plasmacytomas and developed thrombotic microangiopathy (TMA) after starting treatment with carfilzomib, lenalidomide, and dexamethasone (KLd).
- After the diagnosis of TMA on day 7 of treatment, KLd therapy was stopped, leading to improvement in TMA symptoms, indicating a strong link between the drug and the condition.
- After reducing the dose of KLd and achieving a very good partial response (VGPR), the patient has remained in remission, suggesting that dose adjustment for patients experiencing TMA might be a viable option in effective treatments.
Schnitzler Syndrome Presenting as a Fever of Unknown Origin with Elevated Alkaline Phosphatase Levels.
Intern Med
May 2023
Department of Rheumatic Diseases, Tokyo Metropolitan Tama-Hokubu Medical Center, Japan.
Schnitzler syndrome (SchS) is a rare, acquired, autoinflammatory disease that is sometimes associated with a fever of unknown origin (FUO). Elevated alkaline phosphatase (ALP) stemming from abnormal bone remodeling is a characteristic laboratory finding of SchS and is included in the diagnostic criteria. However, its utility as a clue to the diagnosis of SchS has been under-emphasized.
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