1 results match your criteria: "Tokyo Metropolitan Hospital Organization Tokyo Metropolitan Tama-Hokubu Medical Center.[Affiliation]"
[Multiple extramedullary plasmacytomas responding to a reduced dose of carfilzomib following drug-induced thrombotic microangiopathy].
Rinsho Ketsueki
January 2023
Department of Hematology, Tokyo Metropolitan Hospital Organization Tokyo Metropolitan Tama-Hokubu Medical Center.
Article Synopsis
- A 79-year-old man with primary plasma cell leukemia experienced multiple extramedullary plasmacytomas and developed thrombotic microangiopathy (TMA) after starting treatment with carfilzomib, lenalidomide, and dexamethasone (KLd).
- After the diagnosis of TMA on day 7 of treatment, KLd therapy was stopped, leading to improvement in TMA symptoms, indicating a strong link between the drug and the condition.
- After reducing the dose of KLd and achieving a very good partial response (VGPR), the patient has remained in remission, suggesting that dose adjustment for patients experiencing TMA might be a viable option in effective treatments.