563 results match your criteria: "Tokyo Medical and Dental University Hospital[Affiliation]"
BMC Musculoskelet Disord
December 2024
Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (Institute of Science Tokyo), 1-5-45 Yushima Bunkyo-Ku, Tokyo, 113-8519, Japan.
Background: The rapid decline in ovarian function associated with menopause promotes osteoclast differentiation and increases bone resorption, disrupting of bone homeostasis and increasing the risk of osteoporosis. Hyaluronic acid (HA) is a polysaccharide ubiquitously present in the connective tissues. Recent reports indicate that high-molecular-weight HA (HMW-HA) promotes osteoblast proliferation, enhances alkaline phosphatase activity and mineral deposition, and promotes the expression of bone differentiation markers, such as Runx2 and osteocalcin.
View Article and Find Full Text PDFClin Gastroenterol Hepatol
December 2024
TMDU Advanced Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:
Background And Aims: While biologic therapy has revolutionized the treatment of Crohn's disease (CD), surgery remains unavoidable in cases involving ileal complications. We aimed to evaluate the efficacy of biologics on proximal ileal lesions using balloon-assisted enteroscopy (BAE).
Methods: This open-label multicenter prospective study was conducted at tertiary referral centers in Japan.
Expert Opin Drug Saf
December 2024
Department of Clinical Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Background: Gastrointestinal (GI) toxicities are among the most common and potentially severe immune-related adverse events (irAEs), and data on risk factors remain limited. This study aimed to identify risk factors for GI-irAEs in patients treated with ICIs.
Research Design And Methods: We conducted a retrospective analysis of patients with any type of malignant tumor who received ICIs between January 2020 and January 2022.
J Trauma Acute Care Surg
January 2025
From the Division of Trauma, Surgical Critical Care, Burns and Acute Care Surgery, Department of Surgery (K.N., W.C., W.J., K.P., D.P., J.W., B.E., T.C.), UC San Diego School of Medicine, San Diego; Comparative Effectiveness and Clinical Outcomes Research Center (R.C.), Riverside University Health System, Loma Linda University School of Medicine, Riverside, California; and Trauma and Acute Critical Care Center (K.N.), Tokyo Medical and Dental University Hospital, Bunkyo-ku, Tokyo, Japan.
Biol Pharm Bull
November 2024
Department of Pharmacokinetics and Pharmacodynamics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.
Bull Tokyo Dent Coll
December 2024
Oral Health Center, Tokyo Medical and Dental University Hospital.
A 38-year-old woman with a history of systemic lupus erythematosus presented at our university hospital with fever, fatigue, and oral pain and was urgently admitted based on a diagnosis of septic shock. Initially, dental infection was suspected based on the symptoms and clinical presentation of purpura accompanied by severe tenderness along the marginal gingiva in the maxilla and mandible. However, subsequent investigations, including an oral examination, radiographic studies, and blood cultures, ruled out dental infection as the cause of the septic shock.
View Article and Find Full Text PDFJ Cardiovasc Electrophysiol
November 2024
Department of Cardiovascular Medicine, Tokyo Medical and Dental University Hospital, 1-5-45 Yushima, Bunkyo-ku, 113-8510, Tokyo, Japan.
Purpose: Very high-power short-duration (vHPSD) ablation creates shallower lesions, potentially reducing efficacy. This study aims to identify factors leading to insufficient lesions during pulmonary vein antral isolation (PVAI) with vHPSD-ablation and to develop an optimized PVAI strategy using this technology.
Methods: PVAI was performed on 41 atrial fibrillation patients using vHPSD-ablation (90 W/4 s).
Oral Maxillofac Surg
November 2024
Department of Dental Anesthesiology and Orofacial Pain Management, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan.
Objective: The Drug Lymphocyte Stimulation Test (DLST), recognized for its safety as an allergy diagnostic modality, has been acknowledged for its utility in diagnosing drug-induced pathological conditions. However, reports elucidating DLST outcomes concerning local anesthetics are notably scarce.
Materials And Methods: An exhaustive analysis was conducted on the DLST results pertaining to local anesthetics derived from 571 patients presenting with suspected allergies to these specific agents.
Heart Rhythm
October 2024
Department of Cardiovascular Medicine, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
Clin Pediatr Endocrinol
October 2024
Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors often linked to underlying genetic variants. Genetic analysis can promote gene-adjusted, specific follow-up, and surveillance protocols for both patients and their families at risk. We report the case of a 7-yr-old boy with bilateral pheochromocytoma, which recurred a year after partial adrenalectomy.
View Article and Find Full Text PDFJ Dermatol
September 2024
Department of Dermatology, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
Circ J
November 2024
Genome Medical Science Project, National Center for Global Health and Medicine.
Intern Med
September 2024
Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan.
We present a 76-year-old man with cryptogenic new-onset refractory status epilepticus (C-NORSE) with an initial abnormal signal in the nucleus accumbens and a remarkable hyperintense signal on T1-weighted magnetic resonance imaging in the bilateral basal ganglia (BG). His status epilepticus did not respond to most anti-epileptic therapies or immunotherapies, and he died of sepsis. An autopsy revealed severe neuronal loss and hypertrophic astrocytes in the BG and limbic system, with no signs of inflammation or malignancy.
View Article and Find Full Text PDFJ Pharm Health Care Sci
September 2024
Department of Pharmacy, Faculty of Medicine, Mie University Hospital, Mie University, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
J Imaging
August 2024
Department of Diagnostic Radiology, Tokyo Medical and Dental University Hospital, Tokyo 113-8510, Japan.
Eur J Drug Metab Pharmacokinet
November 2024
Department of Pharmacy, Faculty of Medicine, Mie University Hospital, Mie University, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Background And Objectives: A pharmacokinetic model has been developed to quantify the drug-drug interactions of tacrolimus with concentration-dependent inhibition of cytochrome P450 (CYP) 3A4 from voriconazole and clarithromycin based on the CYP3A5 and CYP2C19 genotypes.
Methods: This retrospective study recruited unrelated bone marrow transplant recipients receiving oral tacrolimus concomitantly with voriconazole and clarithromycin. The published population pharmacokinetic model that implemented genotypes of CYP3A5 (tacrolimus) and CYP2C19 (voriconazole) was integrated.
J Prosthet Dent
September 2024
Professor, Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Although methods have been developed to fabricate complete digital dentures, a digital workflow of fabrication methods for complete dentures with metal frameworks such as implant overdentures has not yet been established. The purpose of this dental technique article was to provide a comprehensive description of implant overdenture fabrication techniques using a digital workflow originally devised by applying the custom disk method. In this method, the custom disk was made of resin and contained prefabricated artificial teeth.
View Article and Find Full Text PDFKidney Int Rep
September 2024
Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Case Rep Surg
August 2024
Department of Radiology Tokyo Medical and Dental University Hospital, Yushima 1-5-45 Bunkyo-ku, Tokyo 113-8519, Japan.
Autoimmune neutropenia (AIN) is an extremely rare condition, and there is no effective treatment option for this disorder. AIN can cause major complications in patients with perioperative infection. Herein, we present a 56-year-old female patient who was scheduled for breast cancer surgery.
View Article and Find Full Text PDFJ Infect Chemother
August 2024
Department of Pharmacy, Saiseikai Futsukaichi Hospital, Fukuoka, Japan.
Background: Efforts to promote antimicrobial stewardship aimed at reducing antimicrobial resistance are necessary regardless of hospital scale owing to delays in new antimicrobial development. We aimed to evaluate the effects of pharmacist-driven interventions on broad-spectrum antimicrobial usage and the prognosis of patients with bacteremia in a medium-sized hospital lacking infectious disease physicians and a microbiology laboratory.
Methods: This single-center, retrospective, pragmatic, quasi-experimental study was conducted to compare pre- and post-intervention effects at Saiseikai Futsukaichi Hospital.
Orthop J Sports Med
August 2024
Department of Joint Surgery and Sports Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Background: Understanding the factors related to patient-reported outcomes (PROs) after anterior cruciate ligament reconstruction (ACLR) can lead to more effective interventions.
Purpose/hypothesis: The purpose of this study was to identify factors associated with PRO scores after ACLR. It was hypothesized that concomitant meniscal treatment and postoperative range of motion (ROM) would be associated with early postoperative PRO scores and that postoperative physical findings would be associated with 2-year postoperative PRO scores.
Biochim Biophys Acta Mol Basis Dis
December 2024
Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address:
COVID-19, caused by SARS-CoV-2 infection, results in irreversible or fatal lung injury. We assumed that necroptosis of virus-infected alveolar epithelial cells (AEC) could promote local inflammation and further lung injury in COVID-19. Since CD8+ lymphocytes induced AEC cell death via cytotoxic molecules such as FAS ligands, we examined the involvement of FAS-mediated cell death in COVID-19 patients and murine COVID-19 model.
View Article and Find Full Text PDFJAMA Netw Open
August 2024
MDS K.K. (Merck Sharp & Dohme LLC, a subsidiary of Merck & Co Inc), Tokyo Japan.
Importance: Delirium is common among older hospitalized adults. In addition to presenting immediate management issues, delirium can increase the long-term risk of dementia, institutionalization, and mortality. Delirium is associated with disrupted sleep, and prior studies suggest that some specific sleep-promoting agents may reduce delirium.
View Article and Find Full Text PDFIntroduction: The safety of hyperbaric oxygen treatment (HBO) in patients with cardiovascular implanted electronic devices (CIED) remains unclear.
Methods: We conducted a retrospective analysis of seven CIED patients (median age 79 [73-83] years, five males [71.4%]), including five with pacemakers and two with implantable cardioverter defibrillators (ICD), who underwent HBO between June 2013 and April 2023.
Cureus
July 2024
Trauma and Acute Critical Care Center, Tokyo Medical and Dental University Hospital, Tokyo, JPN.
Splenic artery aneurysm (SAA) is the most common visceral artery aneurysm and can lead to severe outcomes if ruptured. This report presents the case of a 71-year-old female who experienced a sudden and severe gastrointestinal hemorrhage 19 years after undergoing pancreaticoduodenectomy for pancreatic head cancer. The patient arrived at the hospital with signs of shock, and imaging revealed an SAA rupture with associated gastric perforation.
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