1,487 results match your criteria: "Tokyo Medical and Dental University Graduate School.[Affiliation]"
Database analysis of hypersensitivity pneumonitis in Japan.
Respir Investig
March 2023
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. Electronic address:
Background: Three epidemiological small-scale studies on hypersensitivity pneumonitis (HP) have been performed in Japan to date. Herein, we aimed to clarify the clinical characteristics of various types of HP diseases using a large nationwide database in Japan.
Methods: We used the Japanese Diagnostic Procedure Combination database that includes data from 1,031 participant hospitals.
Initial manifestations in Patients with Inborn Errors of Immunity Based on Onset Age: a Study from a Nationwide Survey in Japan.
J Clin Immunol
May 2023
Department of Pediatrics, University of Tsukuba Hospital, Ibaraki, Japan.
Article Synopsis
- - The study investigates the initial symptoms of inborn errors of immunity (IEI) in Japan, focusing on identifying critical signs for early diagnosis in patients, particularly infants.
- - Out of 505 analyzed patients, 67.3% exhibited at least one of the ten warning signs of primary immunodeficiency (PID), with infections being the most common initial symptoms across all ages, while immune dysregulation presented less frequently.
- - The findings emphasize the importance of recognizing the ten warning signs as key indicators for early diagnosis of IEI, especially given the varied symptom presentations based on age and disease category.
Article Synopsis
- Acute pancreatitis (AP) is a rare complication of inflammatory bowel disease (IBD), and while studies in the West suggest similar severity to the general population, this is less explored in Eastern countries using biologics.
- This study analyzed data from 1138 AP admissions, comparing IBD patients (divided into ulcerative colitis and Crohn's disease) to those without IBD, finding lower rates of severe AP in IBD groups.
- The results indicated no significant difference in severe AP rates between Crohn's disease patients and non-IBD groups, and the use of biologics did not seem to affect AP severity, suggesting further research is needed.
Impact of policy alterations on elective percutaneous coronary interventions in Japan.
Heart
March 2023
Department of Healthcare Economics and Quality Management, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Article Synopsis
- The study evaluated the impact of a 2018 reimbursement policy change in Japan that required proof of ischemia for elective percutaneous coronary interventions (PCI) in patients with stable angina pectoris (SAP).
- Researchers analyzed administrative claims data from April 2014 to March 2020, identifying a total of 773,240 PCI procedures and comparing elective PCI trends before and after the policy revision.
- Findings showed a significant decrease in elective PCI procedures per month following the reimbursement revision, while the number of emergency PCIs remained constant.
Mortality analysis among sepsis patients in and out of intensive care units using the Japanese nationwide medical claims database: a study by the Japan Sepsis Alliance study group.
J Intensive Care
January 2023
Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan.
Article Synopsis
- Sepsis patients often need specialized care in the ICU, but the impact of ICU management on their survival rates is not well studied, prompting researchers to test if ICU admission improves outcomes.
- A retrospective analysis of data from over 1.1 million sepsis patients in Japan (2010-2017) was conducted, focusing on in-hospital mortality rates between non-ICU and ICU patients, using statistical methods to adjust for differences in patient characteristics.
- Results showed that the unadjusted in-hospital mortality was slightly higher in the ICU (26.2%) compared to non-ICU (22.5%), but after proper adjustments, the ICU mortality rate (25.8%) was lower than non-ICU
Epidemiology of MRI-detected muscle injury in athletes participating in the Tokyo 2020 Olympic Games.
Br J Sports Med
December 2022
Department of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Bunkyo-ku, Tokyo, Japan
Article Synopsis
- Muscle injuries are common in Olympic athletes and can significantly impact competition outcomes; this study looked at the types and locations of these injuries during the Tokyo 2020 Games.
- MRI scans revealed 59 muscle injuries in 59 athletes, primarily affecting the lower extremities (88%) and particularly the hamstrings, with many athletes unable to complete their events.
- The study found that injuries classified as more severe (type c) were linked to a higher likelihood of athletes not finishing their competitions, highlighting the importance of injury classification for recovery and management.
Heterogeneous circulating miRNA profiles of PBMAH.
Front Endocrinol (Lausanne)
January 2023
Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Article Synopsis
- The study focuses on primary bilateral macronodular adrenal hyperplasia (PBMAH), a rare cause of Cushing syndrome, and how its circulating microRNA (miRNA) expression differs from that of non-functioning and cortisol-producing adrenocortical adenomas.
- Researchers analyzed plasma samples from patients with PBMAH, non-functioning adrenocortical adenoma (NFA), and cortisol-producing adrenocortical adenoma (CPA), finding 135 distinct miRNAs that differentiate PBMAH from the other types.
- The results indicate that PBMAH has a unique miRNA expression profile, with two subtypes identified, suggesting a variety in its underlying pathophysiology.
Treatments and outcomes of adult parapharyngeal and retropharyngeal abscess: 1882 cases from a Japanese nationwide database.
Am J Otolaryngol
March 2023
Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Purpose: Although parapharyngeal and retropharyngeal abscesses are potentially fatal deep neck abscesses, there is limited evidence for the treatment courses for adult patients with these abscesses. We aimed to describe the practice patterns and clinical outcomes of adult patients undergoing an emergency surgery for parapharyngeal or retropharyngeal abscesses using a nationwide database.
Materials And Methods: We identified patients aged ≥18 years who underwent emergency surgery for parapharyngeal (para group, n = 1148) or retropharyngeal (retro group, n = 734) abscesses from July 2010 to March 2020, using a nationwide inpatient database.
Factors Associated With Time to Achieve Physical Functional Recovery in Patients With Severe Stroke After Inpatient Rehabilitation: A Retrospective Nationwide Cohort Study in Japan.
Arch Rehabil Res Clin Transl
December 2022
Graduate School of Medicine, International University of Health and Welfare, Tokyo, Japan.
Objective: To describe characteristics of patient with severe stroke (FIM motor score [FIM motor] 20-49 at admission) and examine association between pre-specified factors (age, sex, modified Rankin Scale before stroke onset, body mass index, FIM motor, and FIM cognitive) and time to achieve FIM motor ≥70, that is, self-independent level.
Design: Retrospective cohort study using a large database in Japan.
Setting: Rehabilitation wards.
Rehabilitation of Patients With Acute Ischemic Stroke Who Required Assistance Before Hospitalization Contributes to Improvement in Activities of Daily Living: A Nationwide Database Cohort Study.
Arch Rehabil Res Clin Transl
December 2022
Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan.
Objective: To assess the effect of early implementation of and longer daily duration of rehabilitation on patients with acute ischemic stroke who require assistance with activities of daily living (ADL) before hospital admission.
Design: Nationwide, cohort, observational study from April 2018 to March 2019.
Setting: Acute care hospitals in Japan.
Risk Factors with 30-Day Readmission and the Impact of Length of Hospital Stay on It in Patients with Heart Failure: A Retrospective Observational Study Using a Japanese National Database.
Tohoku J Exp Med
January 2023
Department of Health Administration and Policy, Tohoku University Graduate School of Medicine.
Heart failure is a major disease, and its 30-day readmission (readmission within 30-day after discharge) negatively impacts patients and society. Thus, we need to stratify the risk and prevent readmission. We aimed to investigate risk factors associated with 30-day readmission and examine the impact of length of hospital stay (LOS) on 30-day readmission.
View Article and Find Full Text PDFBackground: The effect of cardiac rehabilitation (CR) on patients undergoing device implantation (DI) for arrhythmias has been reported; however, the implementation status of these patients has not been clarified. This study aimed to verify the implementation status of CR for patients with heart disease who have undergone DI using real-world data.
Methods: This was an observational study using a nationwide administrative database associated with the diagnosis procedure combination (DPC) system in Japan (2014-2018).
Institutional factors associated with early mortality of newly diagnosed acute promyelocytic leukemia.
Blood Cancer J
December 2022
Department of Hematology and Oncology, JR Tokyo General Hospital, Tokyo, Japan.
Article Synopsis
- * Using a nationwide database, researchers compared IBD patients with and without depression, focusing on surgery rates, drug treatments, and in-hospital mortality.
- * Results showed that ulcerative colitis (UC) patients with depression had worse outcomes, suggesting a link between depression and increased disease activity, but causation remains undetermined, necessitating further research.
A metastasis-associated microRNA-based liquid biopsy signature for risk-stratification in colorectal cancer: a multicenter cohort study.
Clin Transl Med
December 2022
Center for Gastrointestinal Research, Center for Translational Genomics and Oncology, Baylor Scott & White Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, USA.
Comparative Safety and Effectiveness of Direct Oral Anticoagulants and Warfarin during Chemotherapy in Cancer Patients with Venous Thromboembolism Aged 75 Years or Older: A Nationwide Inpatient Database Study.
Gerontology
June 2023
Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.
Introduction: Venous thromboembolism (VTE) is a life-threatening complication occurring in cancer patients. Direct oral anticoagulants (DOACs) or warfarin are widely prescribed for treating cancer-associated VTE. However, data are sparse as to the effectiveness and bleeding complications associated with these medications in elderly patients.
View Article and Find Full Text PDFSystematic Review of Clinical and Pathophysiological Features of Genetic Creutzfeldt-Jakob Disease Caused by a Val-to-Ile Mutation at Codon 180 in the Prion Protein Gene.
Int J Mol Sci
December 2022
Department of Neurology and Neurological Science, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, 1-5-45 Yushima Bunkyo-ku, Tokyo 113-8510, Japan.
Article Synopsis
- Genetic Creutzfeldt-Jakob disease (gCJD) is caused by mutated prion proteins and shares similarities with sporadic CJD, especially the V180I-gCJD variant prevalent in Japan.
- This subtype typically presents later in life, progresses slower, and shows fewer symptoms like myoclonus and visual disturbances compared to the classical form.
- Distinct diagnostic features for V180I-gCJD include specific imaging results and laboratory findings, with most patients lacking a family history, suggesting a unique phenotype linked to the mutation.
Effect of discontinuing ongoing education and postprescription feedback on antimicrobial prescriptions at discharge from the emergency department.
Antimicrob Steward Healthc Epidemiol
July 2022
Department of Infectious Diseases, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo Japan.
Multifaceted intervention is preferrable as an ASP strategy in the emergency department (ED). I assessed the effect of discontinuing multifaceted intervention for antimicrobial prescriptions at discharge in the emergency department. The proportion of appropriate prescriptions decreased quickly after discontinuation.
View Article and Find Full Text PDFAssociation between volume of patients undergoing stroke rehabilitation at acute care hospitals and improvement in activities of daily living.
J Stroke Cerebrovasc Dis
February 2023
Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan; Clinical Research Center National Hospital Organization, 2-21 Higashigaoka, Meguro-ku, Tokyo, 152-8621, Japan. Electronic address:
Background: This study aimed to determine the relationship between the annual volume of patients undergoing rehabilitation per hospital and the outcomes of patients admitted for acute stroke.
Methods: This observational study used nationwide administrative data. Data on stroke patients aged ≥ 20 years who underwent rehabilitation were extracted from 1,182 acute care hospitals in Japan.
Early postoperative non-steroidal anti-inflammatory drugs and anastomotic leakage after oesophagectomy.
Br J Surg
January 2023
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
Background: Previous studies have suggested that postoperative non-steroidal anti-inflammatory drug (NSAID) use may increase the risk of anastomotic leakage after colorectal surgery. However, the association between NSAIDs and anastomotic leakage after oesophagectomy is unclear. The aim of this retrospective study was to assess the effect of early postoperative NSAID use on anastomotic leakage after oesophagectomy.
View Article and Find Full Text PDFImpact of coronavirus disease 2019 (COVID-19) pandemic on antimicrobial consumption and antimicrobial resistance at a small, local hospital in Japan.
Antimicrob Steward Healthc Epidemiol
November 2022
Department of Infectious Diseases, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan.
The coronavirus disease 2019 (COVID-19) pandemic negatively affected antimicrobial stewardship programs at hospitals throughout Japan by diverting resources toward managing the pandemic. However, antimicrobial stewardship needs to continue regardless of hospital size or supervening crises. Herein, we discuss the impact of COVID-19 on antimicrobial stewardship at a small, local hospital in Japan.
View Article and Find Full Text PDFPerioperative Surgical Risks in Patients With Hemangioblastomas: A Retrospective Nationwide Review in Japan.
World Neurosurg
February 2023
Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Background: The perioperative risk of sporadic hemangioblastomas (HBs) and von Hippel-Lindau disease (VHL)-associated hemangioblastomas (VHL-associated HBs) remains unclear due to the rare prevalence of HB. Therefore, this study aimed to clarify risk factors for better surgical management of patients with HBs.
Methods: A retrospective analysis of surgically treated HB patients registered in the Diagnosis Procedure Combination database of Japan, between 2010 and 2015, was performed.
Outcomes After Endoscopic Evacuation Versus Evacuation Using Craniotomy or Stereotactic Aspiration for Spontaneous Intracerebral Hemorrhage: Analysis Using a Japanese Nationwide Database.
Neurocrit Care
June 2023
Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Background: Various surgical methods are available for managing large intracerebral hemorrhage. This study compared the prognosis of patients with spontaneous intracerebral hemorrhage who underwent endoscopic evacuation, stereotactic aspiration, and craniotomy by using a nationwide inpatient database in Japan.
Methods: Using the Diagnosis Procedure Combination database, we identified patients who underwent surgery for spontaneous intracerebral hemorrhage within 48 h after admission between April 2014 and March 2018.
New quantitative evaluation of anticipatory postural adjustments using a smartphone in patients with Parkinson's disease.
Physiother Theory Pract
May 2024
Department of Rehabilitation Medicine, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
Objective: To investigate a smartphone-enabled quantitative evaluation of anticipatory postural adjustments (APA) during one-leg stance (OLS) movements among individuals with Parkinson's disease (PD).
Methods: This cross-sectional study included 10 young controls, 10 older individuals, and 13 individuals with PD. A smartphone and accelerometer were attached to the participants' lower back (L5), and the movements of the lower back toward the stance side during OLS were measured.