2 results match your criteria: "Tokyo Institute of Technology 2-12-1 Ookayama Meguro Tokyo 152-8552 Japan pradipta.a.aa@m.titech.ac.jp tanaka.k.dg@m.titech.ac.jp.[Affiliation]"
Therapeutic efficacy of At-radiolabeled 2,6-diisopropylphenyl azide in mouse models of human lung cancer.
Chem Sci
August 2023
Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology 2-12-1 Ookayama Meguro Tokyo 152-8552 Japan
Targeted α-particle therapy (TAT) is an attractive alternative to conventional therapy for cancer treatment. Among the available radionuclides considered for TAT, astatine-211 (At) attached to a cancer-targeting molecule appears very promising. Previously, we demonstrated that aryl azide derivatives could react selectively with the endogenous acrolein generated by cancer cells to give a diazo compound, which subsequently forms a covalent bond with the organelle of cancer cells .
View Article and Find Full Text PDFTargeted 1,3-dipolar cycloaddition with acrolein for cancer prodrug activation.
Chem Sci
April 2021
Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology 2-12-1 Ookayama, Meguro 152-8552 Tokyo Japan
Cytotoxic anticancer drugs used in chemotherapy are often antiproliferative agents that preferentially kill rapidly growing cancer cells. Their mechanism relies mainly on the enhanced proliferation rate of cancer cells and is not genuinely selective for cancer cells. Therefore, these drugs can also significantly affect healthy cells.
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