373 results match your criteria: "Tokushima University School of Medicine.[Affiliation]"
Masui
July 2010
Department of Anesthesiology, Tokushima University School of Medicine, Tokushima 770-8503.
Cardiac arrhythmias are often observed in patients during perioperative period. There are many types of arrhythmias, and some of these can be independent predictors of morbidity and mortality in patients undergoing both cardiac and non-cardiac surgery. In accordance with patients' condition, advanced cardiac testing may be needed for predicting and reducing the perioperative risk.
View Article and Find Full Text PDFAnesthesiology
November 2009
Department of Anesthesiology, Tokushima University School of Medicine, Japan.
Background: Volatile anesthetics impair insulin secretion and glucose utilization; however, the precise mechanism of action that underlies these effects is unknown. The authors hypothesized that isoflurane inhibits glucose-induced inhibition of adenosine triphosphate-sensitive potassium channel activity in pancreatic beta cells, which could result in impaired insulin secretion and glucose tolerance.
Methods: Intravenous glucose tolerance tests were performed on 28 male Japanese White rabbits anesthetized with sodium pentobarbital.
Nihon Hinyokika Gakkai Zasshi
May 2009
Department of Urology, Tokushima University School of Medicine.
A 41 year-old man with a history of diabetes mellitus underwent computed tomography for screening on August 2007. The CT revealed an enhancing 3.0 cm mass in the middle pole of the left kidney.
View Article and Find Full Text PDFJ Appl Toxicol
August 2009
Department of Forensic Medicine, Tokushima University School of Medicine, Kuramoto, Tokushima 770-8503, Japan.
Toluene is one of the most widely used organic solvents and is commonly recognized as a noxious substance inducing chronically toxic damage to neural, hepatic and renal functions in the workers engaged in printing and painting. Although hepatic cells are generally considered to be vulnerable and susceptible to various organic solvents, particularly chloroform and other halogenated hydrocarbons, the hepatotoxic effects of aromatic hydrocarbons including toluene have not yet been sufficiently characterized. In particular, it still seems unclear whether toluene itself can directly act on hepatic cells, inducing toxic damage to their metabolism and function.
View Article and Find Full Text PDFCancer Lett
May 2009
Department of Molecular Bacteriology, Tokushima University School of Medicine, Kuramoto, Tokushima, Japan.
Microbial metabolism of soybean constituents is known to produce novel active substances as a chemopreventive agent during the fermentation, and enterobacteria are expected to produce chemopreventive agents as a consequence of metabolizing soybean constituents in the intestinal tract. Then, the conditioned medium was prepared by culturing an enterobacterium Clostridium butyricum (C. butyricum) with soybean protein, and its direct effect on human colon carcinoma HCT116 cells was examined.
View Article and Find Full Text PDFAnesth Analg
March 2008
Department of Anesthesiology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.
Background: Isoflurane activates vascular adenosine triphosphate sensitive potassium (K(ATP)) channels, and may induce vasodilation. In the present study, we investigated whether hyperglycemia modifies isoflurane activation of vascular K(ATP) channel.
Methods: We used a cell-attached patch-clamp configuration to test the effects of isoflurane on K(ATP) channel activity in vascular smooth muscle cells (VSMCs) after incubation for 24 h in medium containing normal glucose (NG, 5.
J Cardiovasc Pharmacol
February 2008
Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan.
Background: Dopamine is reported to be a coronary vasodilator; however, the exact mechanism of dopamine action in the coronary circulation remains unclear. In this study, we hypothesized that dopamine-induced activation of coronary ATP-sensitive potassium (KATP) channels may be associated with coronary vasodilation. We therefore investigated the direct effects of dopamine on coronary KATP-channel activity.
View Article and Find Full Text PDFJ Cardiothorac Vasc Anesth
February 2008
Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan.
J Mol Neurosci
March 2008
Department of Pharmacology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.
Tricyclic antidepressants and selective serotonin reuptake inhibitors are considered in theory to induce the outflow of neurotransmitters, norepinephrine, and serotonin from the synapses as a consequence of inhibiting their reuptake into the nerve terminals, resulting in the stimulation of glial cells surrounding the synapses in the brain. Then, we have investigated the direct actions of neurotransmitters on glial cell metabolism and function using rat C6 glioma cells as an in vitro model system and suggested that these neurotransmitters induce their differentiation probably through the production of 5alpha-reduced neurosteroids. On the other hand, the stimulation of the glioma cells with serotonin has been reported to enhance brain-derived neurotrophic factor (BDNF) gene expression, which may be closely related to the beneficial effects of antidepressant drugs.
View Article and Find Full Text PDFPharmacology
March 2008
Department of Molecular Bacteriology, Tokushima University School of Medicine, Tokushima, Japan.
Cytotoxic effects of desipramine on human colon carcinoma HT29 and HCT116 cells were examined. Desipramine reduced the viability of HT29 cells in a concentration-dependent manner, but failed to cause any significant change in the viability of HCT116 cells by the concentration up to 50 mumol/l, at which an approximately 60% reduction of the viability of HT29 cells was observed. Despite their different sensitivities, desipramine caused the nonoxidative apoptotic damage to both of them.
View Article and Find Full Text PDFJ Anesth
January 2008
Department of Anesthesiology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.
Purpose: Propofol inhibits adenosine triphosphate-sensitive potassium (K(ATP)) channels, which may result in the blocking of ischemic preconditioning in the heart. During cardiac ischemia, sarcolemmal K(ATP) channel activity is regulated by the increased levels of cytosolic metabolites, such as adenosine diphosphate (ADP) and protons. However, it remains unclear whether these cytosolic metabolites modulate the inhibitory action of propofol.
View Article and Find Full Text PDFJ Mol Neurosci
February 2008
Department of Pharmacology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Tokushima, Japan.
Recent studies have suggested that glial cells may play a physiologically important role in the retention and restoration of neuronal cell integrity, proposing the possibility that the proliferation and/or differentiation of glial cells may be related to pathological changes in neural functions in neurodegenerative diseases, and hence, it seems interesting to investigate the expression of genes related to the proliferation and differentiation of glial cells. Following this basic concept, we have previously examined the influence of culture conditions on egr-1 gene expression in rat C6 glioma cells and have shown that brief exposure of these cells to high salt culture medium can induce the down-regulation of egr-1 gene expression. In contrast, the long-term culture of these cells in high salt medium has been shown to primarily reduce their proliferation and secondarily elevate egr-1 gene transcription as a consequence of arresting the cell-cycle progression.
View Article and Find Full Text PDFWorld J Gastroenterol
May 2007
Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, Tokushima University School of Medicine, Kuramoto-cho, Tokushima 770-8503, Japan.
Although spinal tumors are uncommon, they may reduce survival or cause serious functional disorders in the extremities. Metastatic spinal tumors from malignant tumors can induce symptoms of spinal cord compression, such as paraplegia, quadriplegia, and vesicorectal disturbance, which are aggravated with progression of the diseases and time. We report a patient with hepatocellular carcinoma (HCC) who was suspected of having spinal lesions based on neurological findings, and a metastatic spinal tumor was found by imaging examination.
View Article and Find Full Text PDFAnesthesiology
May 2007
Department of Anesthesiology, Tokushima University School of Medicine, Kuramoto, Tokushima, Japan.
Background: Recent evidence indicates that vascular adenosine triphosphate-sensitive potassium (K(ATP)) channels in vascular smooth muscle cells are critical in the regulation of vascular tonus under both physiologic and pathophysiologic conditions. Studies of the interaction of volatile anesthetics with vascular K(ATP) channels have been limited. In the current study, the authors investigated the molecular mechanism of isoflurane's action on vascular K(ATP) channels.
View Article and Find Full Text PDFRinsho Byori
September 2006
Department of Laboratory Medicine, Tokushima University School of Medicine, Tokushima 770-8503.
Diabetes mortality rates of Tokushima prefecture have been worst one in Japan for 12 years. We started up the organization named "Tokushima Medical Doctors Association against Diabetes" for the disease prevention and the improvement of the treatments in Tokushima prefecture. More than 240 medical doctors in Tokushima prefecture joined the association.
View Article and Find Full Text PDFGynecol Oncol
December 2006
Department of Radiology, Tokushima University School of Medicine, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
Objective: To investigate the incidence, clinical and imaging finding of insufficiency fractures (IF) of the female pelvis following radiation therapy.
Methods: We reviewed the radiation oncology records of 158 patients with gynecologic malignancies who underwent external beam radiation therapy of the whole pelvis between April 1993 and March 2004. All patients underwent computed tomography (CT) scan every 6 months in follow-up after radiation therapy and magnetic resonance imaging (MRI) and radionuclide bone scan were added when the patients complained of a pelvic pain.
Eur J Pharmacol
July 2006
Department of Molecular Bacteriology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.
Preclinical studies have suggested that the long-term use of antidepressants may result in the initiation and/or promotion of tumor in the gastrointestinal tract. However, a possible relationship between the use of antidepressants and the production of colon cancer has not yet been confirmed, and hence requires to be further investigated. To address this issue, the effects of antidepressants on the proliferation of colorectal tumor cells were examined using human HT29 colon carcinoma cells, and tricyclic antidepressant, such as imipramine, desipramine and amitriptyline, were shown to reduce the cell viability in a manner dependent on the time exposing to these drugs.
View Article and Find Full Text PDFRadiat Med
February 2006
Departments of Radiology, Tokushima University School of Medicine, Japan.
Purpose: To retrospectively evaluate the toxicity of concurrent weekly cisplatin and radiation therapy (RT) for locally advanced cervical cancer.
Materials And Methods: Between April 2001 and December 2004, 21 consecutive previously untreated patients with locally advanced cervical cancer were treated with concurrent chemoradiation therapy (CCRT) at the Tokushima University Hospital. Clinical stages were II: 5, III: 15, IVA: 1.
Brain Res
April 2006
Department of Pharmacology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.
Influence of adrenergic and serotonergic stimulation on glial fibrillary acidic protein (GFAP) gene expression in rat C6 glioma cells was first examined as an in vitro model experiment for investigating the neuronal regulation of glial cell differentiation. Stimulation of these cells with isoproterenol and serotonin elevated GFAP mRNA levels followed by an increase in its protein contents, thus suggesting that both adrenergic and serotonergic stimulation might induce the differentiation of the glioma cells. In addition, progesterone and its 5alpha-reduced metabolite dihydroprogesterone also elevated GFAP mRNA levels in rat C6 glioma cells, consistent with their stimulatory actions on GFAP gene expression observed in rat astrocytes.
View Article and Find Full Text PDFClin Pediatr Endocrinol
May 2014
Department of Pediatrics, Konan Hospital, Sapporo, Japan.
Gitelman syndrome (GS) is a renal tubular disorder characterized by hypokalemia, hypomagnesemia, metabolic alkalosis and hypocalciuria due to defective tubular reabsorption of magnesium and potassium. This disease is caused by mutations of the thiazide-sensitive Na-Cl cotransporter (NCCT) gene, SLC12A3. Manifestations of GS are heterogeneous, from asymptomatic to mild symptoms of cramps and easy fatigue, to tetany and paralysis.
View Article and Find Full Text PDFJ Mol Neurosci
February 2006
Department of Molecular Bacteriology, Tokushima University School of Medicine, Kuramoto, Tokushima, Japan.
As one of the in vitro model experiments for investigating a possible effect of extracellular environmental stresses on glial cell proliferation, the influence of high salt culture conditions on the growth of rat C6 glioma cells was examined. Exposure to the culture medium containing high concentrations of NaCl reduced the number of viable cells in a concentration-dependent manner without any significant change in their viability. In contrast, proliferation of these cells was not substantially altered by culturing them in hyperosmotic medium containing either sucrose or glycerol, both of which were osmotically almost equivalent to high salt culture medium.
View Article and Find Full Text PDFMasui
October 2005
Department of Anesthesiology, Tokushima University School of Medicine, Tokushima.
A 3-month-old boy with Pena-Shokeir syndrome underwent tracheotomy under general anesthesia. Patients with this syndrome may present anesthetic problems involving difficulties in tracheal intubation, possibilities of malignant hyperthermia, as well as perioperative respiratory complications related to hypoplasia of the lung. General anesthesia was induced and maintained with sevoflurane (2-3%) and nitrous oxide (0-50%) in oxygen (50-100%).
View Article and Find Full Text PDFBiotechnol Annu Rev
July 2006
Department of Dermatology, Tokushima University School of Medicine, Tokushima 770-8503, Japan.
Understanding the molecular, cellular and tissue changes that occur during skin carcinogenesis is central to cancer research in dermatology. The translational aspects of this field--the development of clinical applications in dermatology from the laboratory findings--aim at improving clinical diagnosis, monitoring and treatment of skin cancer. Vibrational spectroscopy, both infrared (IR) and Raman spectroscopy, would be helpful in achieving those goals, since it has been shown to have potential in characterising and discriminating tumour and dysplastic tissue from normal tissue.
View Article and Find Full Text PDFMasui
June 2005
Department of Anesthesiology, Tokushima University School of Medicine, Tokushima.
Background: We investigated the effects of a novel highly cardioselective short-acting beta-blocker, landiolol, on cardiovascular response, bispectral index and body movement during endotracheal
Methods: Forty ASA class 1 patients were randomly allocated into 2 groups, in a double-blind fashion; 1) 20 patients received landiolol 125 microg x kg(-1) x min(-1) for one minute followed by 40 microg x kg(-1) x min(-1) (landiolol group), and 2) 20 patients received saline (control group). Landiolol or saline was started 6 min after a target controlled infusion of propofol (effect-site concentration 4 microg x ml(-1)). The trachea was intubated 11 min after propofol infusion.
Brain Res Mol Brain Res
October 2005
Department of Pharmacology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.
Selective serotonin reuptake inhibitors (SSRIs) are widely used for the treatment of depressive mood disorders and well known to inhibit the reuptake of neurotransmitter serotonin into nerve terminals. Thus, it seems conceivable that these drugs may induce the outflow of serotonin from the synapse as a consequence of inhibiting the reuptake, resulting in the stimulation of glial cells surrounding nerve terminals. On this hypothesis, the effect of serotonin on steroid 5alpha-reductase type 1 (5alpha-R) gene expression in rat C6 glioma cells was examined as one of the in vitro model experiments for investigating the indirect influence of SSRIs on glial cells.
View Article and Find Full Text PDF