4 results match your criteria: "Tokushima University Graduate School of Medical Nutrition[Affiliation]"
Modulations of the mTORC2-GATA3 axis by an isorhamnetin activated endosomal-lysosomal system of the J774.1 macrophage-like cell line.
J Clin Biochem Nutr
July 2024
Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School of Medical Nutrition, 3-18-15 Kuramoto-cho, Tokushima-shi, Tokushima 770-8503, Japan.
Article Synopsis
- The endosomal-lysosomal system is essential for breaking down extracellular substances, and its malfunction is associated with diseases like cardiovascular and neurodegenerative disorders.
- While the process involves steps like uptake, transportation to lysosomes, and digestion, the exact regulation of cargo transport is not well understood.
- A study found that the flavonoid isorhamnetin boosts this degradation process independently of known signals, revealing the role of the transcription factor GATA3 and the mTORC2-GATA3 axis, which could serve as a new target for improving the removal of abnormal substances.
Elevated luminal inorganic phosphate suppresses intestinal Zn absorption in 5/6 nephrectomized rats.
Am J Physiol Renal Physiol
March 2024
Department of Clinical Nutrition and Food Management, Tokushima University Graduate School of Medical Nutrition, Tokushima, Japan.
Article Synopsis
- Zinc is essential for various biological processes, but chronic kidney disease (CKD) often leads to decreased zinc levels (hypozincemia), which can worsen CKD progression.
- In a rat model of CKD, researchers found that while zinc absorption was impaired, a protein involved in zinc transport (ZIP4) was actually upregulated, suggesting other factors were at play.
- They identified elevated phosphate levels as a key inhibitor of zinc absorption, and managing phosphate levels could help improve zinc status in CKD patients.
Humoral and cellular factors inhibit phosphate-induced vascular calcification during the growth period.
J Clin Biochem Nutr
November 2023
Department of Clinical Nutrition and Food Management, Tokushima University Graduate School of Medical Nutrition, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
Hyperphosphatemia is an independent and non-classical risk factor of cardiovascular disease and mortality in patients with chronic kidney disease (CKD). Increased levels of extracellular inorganic phosphate (Pi) are known to directly induce vascular calcification, but the detailed underlying mechanism has not been clarified. Although serum Pi levels during the growth period are as high as those observed in hyperphosphatemia in adult CKD, vascular calcification does not usually occur during growth.
View Article and Find Full Text PDF25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) induces ectopic calcification.
J Clin Biochem Nutr
September 2022
Department of Clinical Nutrition and Food Management, Tokushima University Graduate School of Medical Nutrition, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
Vascular calcification is an important pathogenesis related to cardiovascular disease and high mortality rate in chronic kidney disease (CKD) patients. It has been well-known that hyper-phosphatemia induces osteochondrogenic transition of vascular smooth muscle cells (VSMCs) resulting ectopic calcification in aortic media, cardiac valve, and kidney. However, the detailed mechanism of the ectopic calcification has been not clarified yet.
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