644 results match your criteria: "Tokai University Hachioji Hospital.[Affiliation]"

Background: Few studies have evaluated home-based cardiac rehabilitation (HBCR) during the pandemic, compared to prepandemic center-based CR (CBCR), with respect to patient characteristics, participation rates, and its efficacy on clinical metrics, health-related quality of life (QoL), and modifiable risk factors.

Objectives: We aimed to describe patient characteristics and participation rates for those attending HBCR compared to patients who attended CBCR and compare the effects of HBCR vs CBCR on clinical metrics, health-related QoL, and modifiable risk factors in CR patients pre vs during the COVID-19 pandemic.

Methods: A retrospective cohort study comparing 511 HBCR patients and 765 CBCR patients from the Mayo Clinic Health System.

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Atezolizumab, an immune checkpoint inhibitor (ICI), was used in a phase III clinical trial, i.e., the OAK trial, of previously treated patients with non-small cell lung cancer.

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Background: To evaluate clinical outcomes of focal therapy using high-intensity focused ultrasound (HIFU) with intraoperative prostate compression for patients with localized prostate cancer (PC).

Methods: Patients were included if they had prostate specific antigen levels of ≤20 ng/mL and clinically significant PC (CSPC) within the left or right half, or upper or lower half of the prostate. CSPC was detected using magnetic resonance imaging-transrectal ultrasound fusion image-guided target biopsy and a 12-core systematic biopsy.

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Background: Spontaneous anterior interosseous nerve (AIN) palsy is characterized by the sudden onset of upper limb pain followed by weakness of muscles mainly innervated by the AIN. Although this palsy is conventionally treated conservatively, interfascicular neurolysis to release hourglass-like fascicular constrictions has been recommended. The present study aimed to establish the clinical characteristics and treatment strategy for this condition.

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Background: The mortality rate of splenic artery aneurysm rupture is very high, and patients with aneurysms larger than 30 mm are recommended for treatment, regardless of the presence or absence of symptoms. We herein report a case of splenic artery aneurysm with an abnormal bifurcation that was treated with laparoscopic ligation of the splenic artery.

Case Presentation: A 51 year-old Japanese male was referred to our hospital because a splenic artery aneurysm was noted on abdominal echocardiography during a medical examination.

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Background: We developed a novel method to measure the angle of subjective postural vertical (SPV) and showed that the SPV may be related to the exacerbation of the forward flexed posture.

Objectives: The present study prospectively tested the effects of the subjective postural vertical on the exacerbation of the forward flexion of trunk (FFT) through long-term observation of Parkinson's disease patients.

Methods: Evaluation of the posture included measuring FFT, the angle of lateral flexion of trunk, and the angle at the position that the patient subjectively perceived as the vertical position at a stationary upright position immediately after standing up at the time of initial observation, 6 months later, and 1 year later.

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Background: The information on the clinicopathologic/outcome differences between ampullary adenocarcinoma (AC) and pancreatic adenocarcinoma (PC) has been conflicting to the extent that it still is questioned whether ACs need to be recognized separately from PCs.

Methods: The characteristics of 413 ACs were compared with those of 547 PCs.

Results: The ACs had a better prognosis than the PCs (5-year survival, 57 % vs 23 %; p < 0.

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Article Synopsis
  • - Non-invasive evaluation of pulmonary blood flow is crucial for Understanding gas exchange in the lungs, and a chest digital dynamic radiography system (CDDR) can provide visual and quantitative data by capturing changes in lung radiographic transparency in sync with the heartbeat.
  • - The lung-diffusing capacity (DLCO) test assesses factors related to the alveolar membrane and blood flow, and changes in DLCO can indicate variations in pulmonary blood flow, especially in patients with conditions like anaemia or without visible interstitial abnormalities.
  • - The study compared CDDR results with DLCO measurements among patients categorized by their DLCO levels, revealing that the mean and median pulmonary blood flow values obtained through CDDR were significantly lower in those with reduced DLCO,
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The breath-hold (BH) 3D magnetic resonance cholangiopancreatography method has been reported to suppress "respiratory artifacts"; however, the influence of gastrointestinal peristalsis around the target organs has not been discussed. In contrast, the autonomic nervous system has been reported to affect gastrointestinal peristalsis and BH imaging has been reported to influence venous blood flow signal (BFS) through its involvement with the autonomic nervous system. We examined the impact of BH imaging on gastrointestinal peristalsis.

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Primary Percutaneous Coronary Intervention (PCI) has significantly contributed to reducing the mortality of patients with ST-segment elevation myocardial infarction (STEMI) even in cardiogenic shock and is now the standard of care in most of Japanese institutions. The Task Force on Primary PCI of the Japanese Association of Cardiovascular Intervention and Therapeutics (CVIT) proposed an expert consensus document for the management of acute myocardial infarction (AMI) focusing on procedural aspects of primary PCI in 2018 and updated in 2022. Recently, the European Society of Cardiology (ESC) published the guidelines for the management of acute coronary syndrome in 2023.

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Article Synopsis
  • The study focused on comparing the effectiveness of Pipet Curet cytology (PCC) and Pipet Curet biopsy (PCB) for diagnosing endometrial endometrioid carcinoma (EEC) in 77 patients, categorized based on the Federation of Gynecology and Obstetrics (FIGO) grades.
  • Results showed that the diagnostic sensitivity was significantly higher for advanced G2/3 EEC cases than for G1 EECs across all methods, indicating that more aggressive cancer types yield easier detection.
  • The combination of both PCC and PCB improved diagnostic accuracy, suggesting that using these methods together can reduce false negatives and enhance EEC diagnosis.
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Objectives: Patients with T4 colorectal cancer have poor prognosis, wherein no prognostic factors have been established. Surgical site infection (SSI) has been reported to be one of the risk factors for colorectal cancer recurrence. In this study, we evaluated the relationship between SSI occurrence and prognosis of T4 colorectal cancer and the prognostic impact of the site of SSI occurrence.

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Deuterium-depleted water (DDW) is used in the treatment of many diseases, including cancer and diabetes. To detect the effect of DDW on gene expression and activation of the insulin-responsive transporter GLUT4 as a mechanism for improving the pathology of diabetes, we investigated the GLUT4 expression and glucose uptake at various concentrations of DDW using the myoblast cell line C2C12 differentiated into myotubes. GLUT4 gene expression significantly increased under deuterium depletion, reaching a maximum value at a deuterium concentration of approximately 50 ppm, which was approximately nine times that of natural water with a deuterium concentration of 150 ppm.

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Article Synopsis
  • * The treatment involved antibiotics, extraction of a decayed tooth, and drainage of the sinuses and abscess, with a positive prognosis after 1 year and 5 months without complications.
  • * The case highlighted a potential link between dental infections and serious conditions like brain abscesses, emphasizing the need for timely dental care in children.
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Background: Spontaneous mesenteric hematoma is a rare condition that is diagnosed when clinical and pathological findings do not identify an obvious causative disease. Various treatment options for spontaneous mesenteric hematoma exist; however, there are no clear treatment criteria. Herein, we report a case of spontaneous mesenteric hematoma that was successfully treated surgically and discuss the optimum treatment strategy based on similar cases.

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Article Synopsis
  • Researchers developed a machine learning-based software program for analyzing lung sounds in infants and children to assess airway conditions.
  • The program demonstrated strong reliability and reproducibility in studies involving younger and older children, unaffected by airflow conditions.
  • The findings revealed that infants with a history of wheezing or asthma showed significant differences in lung sound parameters compared to healthy infants, proving the software's potential for early asthma detection and intervention.
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Article Synopsis
  • Pancreaticoduodenectomy (PD) is a complex surgery, especially when dealing with vascular structures and tumors in patients who have had previous surgeries like esophageal cancer reconstruction.
  • The case presented involves a 76-year-old man with pancreatic head cancer and median arcuate ligament syndrome (MALS), who had previously undergone gastric tube reconstruction.
  • This unique surgical procedure utilized advanced imaging techniques to preserve blood flow to critical arteries, ensuring the patient's vascular integrity during and after the operation.
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Background: Elderly gastric cancer patients (EGCPs) require treatment according to not just the stage of their cancer, but also to their general condition and organ function, and rather than full treatment, the appropriate amount of treatment is necessary.

Methods: A total of 425 patients who underwent gastrectomy for primary gastric cancer in our institution between April 2013 and March 2020 were classified by age into two groups: elderly patients (EP, age ≥ 80 years, n = 89); and younger patients (YP, age < 80 years, n = 336). The preoperative, intraoperative, and postoperative conditions of the two groups were then compared.

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Purpose: This study aimed to assess reliable options for bedside diagnosis of silent aspiration in the intensive care unit by examining the use of default grayscale images (DGI) obtained using a mobile, general-purpose, radiography system capable of dynamic digital radiography (M-DDR) and inverted grayscale images (IGI) of DGI.

Methods: This cohort study (exploratory and preliminary) involved 18 adult patients (mean age, 89.0 years) for whom a swallowing assessment request was received from their primary physicians.

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Disease-Modifying Effects of Lenvatinib, a Multiple Receptor Tyrosine Kinase Inhibitor, on Posttraumatic Osteoarthritis of the Knee.

Int J Mol Sci

June 2024

Department of Orthopaedic Surgery, Surgical Science, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Kanagawa, Japan.

Angiogenesis and vascular endothelial growth factor (VEGF) are involved in osteoarthritis (OA). We previously reported the inhibitory effect of bevacizumab in a rabbit model of OA. In the current study, we investigated the effects of lenvatinib, an angiogenesis inhibitor targeting the VEGF and fibroblast growth factor receptors, on synovitis, osteophyte formation, and cartilage degeneration in a rabbit OA model.

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Background And Aim: The use of a hood at the tip of a colonoscope enables aspiration, inversion of the diverticulum, and observation of the inside of the diverticulum. In most previous studies, a short hood was used; however, observation of the diverticulum is often inadequate. Long food is promising by previous research, but it was a retrospective study using propensity matching and has some limitations.

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Background: Although various surgical methods are available for unstable distal clavicle fractures, consensus remains lacking on the optimal technique. Therefore, the present retrospective study aimed to compare the clavicle hook plate and Scorpion Plate® in terms of clinical outcomes and radiological findings for unstable distal clavicle fractures.

Methods: Fifty-seven patients with unstable distal clavicle fractures who underwent treatment using a clavicle hook plate (Group H; 28 patients) or Scorpion Plate® (Group S; 29 patients) were included in the present study.

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Objectives Pancreatic stump closure in laparoscopic distal pancreatectomy (Lap-DP) is commonly performed using an automatic stapler. Herein, the magnification effect of laparoscopy was used to observe the pancreatic stump and retrospectively investigate factors that may cause postoperative pancreatic fistula. Methods This is a single-center retrospective study.

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