Elucidation of the Role of FAM210B in Mitochondrial Metabolism and Erythropoiesis.

Mitochondria play essential and specific roles during erythroid differentiation. Recently, , encoding a mitochondrial inner membrane protein, has been identified as a novel target of GATA-1, as well as an erythropoietin-inducible gene. While FAM210B protein is involved in regulate mitochondrial metabolism and heme biosynthesis, its detailed function remains unknown.

Distinct Regulations of Gene Expression for Stress Response and Substrate Induction.

Heme oxygenase 1 (HO-1) is the key enzyme for heme catabolism and cytoprotection. Whereas gene expression in response to various stresses has been investigated extensively, the precise mechanisms by which gene expression is regulated by the HO-1 substrate heme remain elusive. To systematically examine whether stress-mediated induction and substrate-mediated induction of utilize similar or distinct regulatory pathways, we developed an HO-1-DsRed-knock-in reporter mouse in which the gene is floxed by loxP sites and the gene has been inserted.