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Preventing effects of joint contracture by high molecular weight hyaluronan injections in a rat immobilized knee model.
Int J Clin Exp Pathol
April 2017
Department of Orthopaedic Surgery, Tohoku University School of Medicine 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Purpose: To elucidate preventive effects of high molecular weight hyaluronan (HMWHA) on the joint capsule of immobilized knees in rats.
Materials And Methods: Unilateral knee joints of rats were immobilized with an internal fixator. Either 50 μl of HMWHA (Im-HA group) or 50 μl of saline (control group) was administered intra-articularly once a week after surgery.