Differential expression of osteoblast-like cells on self-organized titanium dioxide nanotubes.

Background/purpose: Titanium dioxide nanotube (TNT) structures have been shown to enhance the early osseointegration of dental implants. Nevertheless, the optimal nanotube diameter for promoting osteogenesis remains unclear due to variations in cell types and manufacture of nanotubes. This study aimed to evaluate the differences in MC3T3-E1 and Saos-2 cells behavior on nanotubes of varying diameters.

Effects of flushing of dental waterlines in portable dental units on water quality management.

Background/purpose: Daily flushing of dental unit waterlines is important for infection control. However, the effect of flushing on water quality management in portable dental units (PDUs) for mobile dental treatments remains unclear. In this study, we aimed to investigate the factors affecting the effectiveness of PDU flushing.

Bidirectional longitudinal associations between subjective oral health and subjective well-being.

Objective: This study investigated the bidirectional longitudinal association between subjective oral health (SOH) and subjective well-being (SWB) over time.

Methods: This cohort study was based on a four-wave surveys conducted by the English Longitudinal Study of Aging. SOH was measured by oral impacts on daily performance (OIDP), self-rated oral health (SROH), and SWB was measured by the Center for Epidemiologic Studies-Depression (CES-D) scale, Control, Autonomy, Self-Realization, and Pleasure (CASP-19), and satisfaction with life scale (SWLS).

Solitary median maxillary central incisor syndrome caused by 22q11.2 microdeletion.

Solitary median maxillary central incisor (SMMCI) syndrome, the mildest form of the holoprosencephaly spectrum, is a rare anomaly characterized by the presence of a single midline central incisor in both the deciduous and permanent dentitions. Affected individuals can present with additional midline defects beyond dental findings. The 22q11.

Correlates of COVID-19 conspiracy theory beliefs in Japan: A cross-sectional study of 28,175 residents.

Background: The COVID-19 pandemic was associated with an increase in conspiracy theories worldwide. However, in Japan, the prevalence of COVID-19 conspiracy beliefs has remained unclear. This study aimed to estimate the prevalence and correlates of COVID-19 conspiracy beliefs using a survey of 28,175 residents of Japan aged 16-81 years old.

Association between equivalized annual household income and regular medical visits for hypertensive patients since the COVID-19 outbreak.

Previous studies have shown an increase in blood pressure during the coronavirus disease 2019 (COVID-19) pandemic even among patients receiving antihypertensive treatment. This study aims to evaluate the association between equivalized annual household income and refraining from regular medical visits for hypertensive patients since the COVID-19 outbreak. We analyzed data from the Japan COVID-19 and Society Internet Survey (JACSIS), including 2832 hypertensive patients aged 20-79 years from the 2020 survey and at least one survey between 2021 and 2023.

Periodontal Care Is Associated With a Lower Risk of Dialysis Initiation in Middle-Aged Patients With Type 2 Diabetes Mellitus: A 6-Year Follow-Up Cohort Study Based on a Nationwide Healthcare Database.

Objective: To investigate the association between dental attendance with periodontal care and the risk of dialysis initiation in patients with type 2 diabetes mellitus (T2D).

Methods: This retrospective cohort study used data from the Japan Medical Data Center (JMDC) claims database (January 2015 to August 2022). Patients with T2D, aged 40-74, were included.

Current perspectives on the dynamic culture of mesenchymal stromal/stem cell spheroids.

Mesenchymal stromal/stem cells (MSCs) are promising candidates for regenerative medicine owing to their self-renewal properties, multilineage differentiation, immunomodulatory effects, and angiogenic potential. MSC spheroids fabricated by 3D culture have recently shown enhanced therapeutic potential. MSC spheroids create a specialized niche with tight cell-cell and cell-extracellular matrix interactions, optimizing their cellular function by mimicking the in vivo environment.

School-Based Fluoride Mouth-Rinse Programs and Dental Caries Treatment Expenditure: An Ecological Study of the NDB Open Data Japan.

Objectives: The prevalence of dental caries is high in Japan, leading to a huge burden of overall expenditure on dental caries treatment for the population. School-based fluoride mouth-rinse (S-FMR) has been implemented as a public health intervention. However, its cost-effectiveness remains unclear, where universal health insurance covers a broad range of dental treatments at relatively low cost.

Japanese clinical practice guidelines for oral cancer, 2023.

The Japanese Society of Oral Oncology and Japanese Society of Oral and Maxillofacial Surgeons have jointly developed clinical practice guidelines for oral cancer (oral squamous cell carcinoma) to improve and standardize the quality of oral cancer treatment in Japan. The first, second, and third editions were published in 2009, 2013, and 2019, respectively, and the 2023 edition was recently developed. In the development of the 2023 edition, 60 clinical questions (CQs) were listed.

Workshop on the Latest Advances in Biomedical Applications of Octacalcium Phosphate.

The first workshop on the "latest advances in biomedical applications of octacalcium phosphate (OCP)" was organized as a satellite symposium to the Bioceramics33 conference in Solothurn, Switzerland, in October 2023. The event brought together leading researchers and industry representatives to present and discuss their latest groundbreaking research aimed at developing and commercializing advanced OCP-based biomaterials for bone regeneration. The topics presented by the six invited speakers ranged from a fundamental understanding of the OCP crystal chemistry to advanced processing and characterization methods, functionalization, biomineralization, and commercialization.

Enhancement of the Cytokine Adsorption Capacity of Octacalcium Phosphate by Interaction-Controlled Glycosaminoglycan Modification to Promote Osteoblastic Differentiation.

This study was designed to investigate how the strength of the interaction between octacalcium phosphate (OCP) and modified chondroitin-A sulfate (CS-A), a glycosaminoglycan, regulates the adsorption-desorption of cytokines and subsequently affects the osteoblastic differentiation of mesenchymal stem cells (MSCs) in vitro. The utilization of cytokines produced by cells, such as macrophages, stimulated by the hydrolysis of OCP, is expected to enhance the bone regeneration capacity of the OCP. CS-Na was used to modify CS-A on the OCP immobilized with the amino group through electrostatic interactions.

Is Postoperative Nausea and Vomiting Associated With Increased Postoperative Pain in Patients Undergoing Minor Oral and Maxillofacial Surgery Under General Anesthesia?

Background: Whether postoperative nausea and vomiting (PONV) contributes to increased postoperative pain (POP) remains unclear, although POP is reported to cause PONV.

Purpose: This study aimed to determine whether PONV following minor oral and maxillofacial surgery (OMS) under general anesthesia increases POP.

Study Design, Setting, Sample: The researchers implemented a retrospective cohort study.

Effects of hypothetical low versus moderate-to-high intensity weight management regimens on knee replacements.

This study aimed to investigate the efficacy of a hypothetical biennial weight management regimen in reducing the necessity for knee replacement (KR) surgery among middle-aged and older adults with or at a higher risk for knee osteoarthritis (OA). Data from the Osteoarthritis Initiative cohort in the US, comprising community-dwelling adults aged 45-79 years at high risk for or with symptomatic knee OA who underwent baseline assessments from September 2008 to December 2010 were used. Subsequent evaluations were conducted at 12, 24, and 96 months.

Anisotropic patterns of nanospikes induces anti-biofouling and mechano-bactericidal effects of titanium nanosurfaces with electrical cue.

Anti-microbial nanopatterns have attracted considerable attention; however, its principle is not yet fully understood, particularly for inorganic nanopatterns. Titanium nanosurfaces with dense and anisotropically patterned nanospikes regulate biological functions with multiple physical stimulations, which may be because of the nanopattern-induced alternation of surface physical properties. This study aimed to determine the antimicrobial capability of titanium nanosurfaces and their mechanisms.

Clinical course of masticatory function recovery following endoscopic-assisted open reduction and internal fixation in patients with unilateral mandibular condyle fracture.

The purpose of this study was to investigate the clinical course of masticatory function recovery following an endoscopic-assisted open reduction and internal fixation (EAORIF) procedure. Patients with a unilateral mandibular condylar fracture who underwent EAORIF for therapeutic purposes were evaluated, with comparisons made between those who underwent the procedure for base or neck fractures. At each time point analyzed after treatment, the occlusal contact area and maximum bite force in patients with a base fracture were greater, although the differences between the groups were not significant.

Mechanical force modulates inflammation and immunomodulation in periodontal ligament cells.

Mechanical forces control a multitude of biological responses in various cells and tissues. The periodontal ligament, located between the tooth's root and alveolar bone, is a major tissue compartment that is incessantly subjected to such mechanical stimulation through either normal or abnormal oral functionality. It is now known that mechanical stimulation activates periodontal ligament stem cells (PDLSCs) to modulate periodontal immunity and regulate inflammation - a basic feature of periodontal disease that affects virtually every human during their lifetime.

Comparative Analysis of Marginal Fit and Fracture Resistance in CAD-CAM Lithium Disilicate and Pre-processed Composite Endocrowns: An Study.

Aim And Background: This study aimed to determine the optimal finish line and material criteria for optimal marginal fit and fracture resistance in endocrowns. The impact of two preparation designs on endocrowns made from computer-aided design and computer-aided manufacturing (CAD-CAM) lithium disilicate and pre-processed CAD/CAM composite was compared.

Materials And Methods: In a randomized 3-arm trial involving 42 mandibular molars, two marginal configurations (with and without chamfer finish lines) were evaluated for each material group.

Bruxism associated with short sleep duration in children with autism spectrum disorder: The Japan Environment and Children's Study.

Bruxism, the involuntary activity of masticatory muscles, is common among individuals with autism spectrum disorders (ASD). Although bruxism is bidirectionally associated with sleep issues, whether an infant's sleep duration contributes to the development of bruxism remains unknown. In this study, a dataset (n = 83,720) obtained from the Japan Environment and Children's Study, a nationwide birth cohort study, was subjected to multiple imputations using logistic regression analysis with adjustments for several maternal and child-related variables.

Development of subgingival calculus detector utilizing optical fiber: Verification of its potential for clinical application.

The removal of subgingival deposits, especially calculus, plays a crucial role in basic periodontal therapy. However, manual detection methods affect accuracy owing to the operator's skill. To avoid this uncertainty, we have developed a calculus detection device named "Sensor probe" and evaluated its ability to detect calculus for future clinical applications.