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Gangliosides in T cell development and function of mice.

Glycoconj J

April 2022

Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology (IMBG), Tohoku Medical and Pharmaceutical University (TMPU), Tohoku, Japan.

The molecular diversity of glycosphingolipids (GSLs) that arouse during the course of evolution clearly plays an essential role in maintenance of biological homeostasis. Why is such a wide variety of GSLs necessary, and what gave rise to the expression mechanisms that are selective and specific to individual cells, tissues, or organs? What is the biological significance of these mechanisms? The same questions apply to GSLs involved in T cell development and activation. Primary CD4 T cells and CD8 T cells preferentially express differing ganglioside series: a-series and o-series, respectively.

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