A plurihormonal TSH-producing pituitary tumor of monoclonal origin in a patient with hypothyroidism.

Objective: A clinicopathological and clonal study of a pituitary tumor was made in a 26-year-old woman with chronic thyroiditis to differentiate TSH-producing adenoma from TSH hyperplasia.

Methods: Tumor specimens were subjected to histopathological study and clonal analysis (HUMARA).

Results: Immunohistochemical examination disclosed TSH-beta, PRL, GH, ACTH, FSH-beta, LH-beta, and alpha-subunit production in the adenoma cells.

Clinicopathological study of Rathke's cleft cysts.

The clinical, radiological and pathological characteristics of Rathke's cleft cyst are analyzed and compared with those of ciliated and goblet cell craniopharyngioma (a subset of papillary craniopharyngioma) to clarify the clinicopathological differences between these conditions. We analyzed 42 patients with Rathke's cleft cyst and 3 patients with ciliated and goblet cell craniopharyngioma. Cyst contents and MRI findings of the cyst generally reflected changing pathology of Rathke's cleft cyst.