Dynamic change in expression of LECT2 during liver regeneration after partial hepatectomy in mice.

Leukocyte-cell-derived chemotaxin 2 (LECT2) was first isolated from the culture fluid of phytohemagglutinin-activated human T-cell leukemia SKW-3 cells and was found to be expressed in the human, bovine and murine livers. To further analyze the role of LECT2 in the liver, we investigated the expression of mouse LECT2 (mLECT2) during liver regeneration after partial hepatectomy (PHx) using immunohistochemical and in situ hybridization techniques. Mouse LECT2 protein and mRNA were detected in most hepatocytes in normal mouse; however, at 30 min after PHx, they were not detected in liver tissue.