DNA mismatch repair (MMR) genes expression in lung cancer and its correlation with different clinicopathologic parameters.

Lung cancer (LC) is a crucial rapidly developing disease. In Egypt, it is one of the five most frequent cancers. Little is known about the impact of deleted mismatch repair genes and its correlation to clinicopathological characteristics.

Investigation of Pharmacokinetic and Pharmacodynamic Interactions between Citalopram and Duloxetine: An Integrated Analytical, Computational, Behavioral, and Biochemical Approach.

Despite the prevalent utilization of antidepressant combinations in clinical settings, concerns persist regarding heightened side effects and potential drug-drug interactions (DDI). In response, this study investigates the interaction between citalopram (CIT) and duloxetine (DUL) using a multifaceted approach encompassing analytical, computational, behavioral, and biochemical techniques. Notably, the absence of published analytical methods tailored for studying antidepressant interactions underscores the novelty of our endeavor.

Assessing awareness of danger signs of pregnancy and its associated factors among pregnant women in Libya: A cross-sectional study.

Background: The maternal mortality rate in Libya surpasses the regional average and is primarily due to sepsis, hemorrhages, hypertension, and other factors, highlighting gaps in maternal knowledge and access to quality care. This study aimed to assess the awareness of obstetric danger signs and associated factors among pregnant women attending the outpatient clinic of Tobruk Medical Center, Libya.

Methods: An institution-based cross-sectional study was conducted from August to October 2023, involving 301 pregnant women visiting the outpatient clinic.

New nano-chemotherapeutic chitosans-garlic oil-antibiotics against diabetic foot virulent spp.

Background And Objectives: Diabetes foot ulcer is recognized to have a major side effect that raises the risk of amputation. Diabetic ulcer bacterial infections caused by virulent and resistant bacteria like lead to serious wounds that are incurable with conventional medications.

Materials And Methods: In this study, we evaluated the antibacterial activity of a natural product nanochitosan - garlic oil against ten diabetic foot isolates of Various chitosans (Crab (CScr) - shrimp (CSsh) - squilla (CSsq)) in nano form were prepared and coated with garlic oil (GO).

Evaluating public awareness and knowledge of multiple sclerosis in Tobruk, Libya: a comprehensive cross-sectional study.

Background: Multiple sclerosis (MS) is a chronic and often disabling disease that impacts the central nervous system, leading to significant public health concerns. This study aimed to assess the level of awareness and knowledge of MS among the population of Tobruk, Libya.

Methods: A community-based cross-sectional study was conducted in Tobruk, Libya, during August 2023.

Endophytic mediated biosynthesis of silver nanoparticles and their antimicrobial and photocatalytic activities.

In the current study, endophytic was used for the biosynthesis of silver nanoparticles (Ag-NPs) for the first time. The characterizations were performed using X ray diffraction (XRD), Transmission electron microscopy (TEM), Scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX), Dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR), and UV-Vis spectroscopy. The obtained results demonstrated the successful formation of crystalline, spherical Ag-NPs with particle diameters ranging from 16 to 31 nm.

A case of successful revascularization and renal recovery after 6 days of renal artery occlusion.

A 72-year-old man with peripheral arterial disease, an atrophic left kidney, and prior right renal chimney stent as part of a complex endovascular abdominal aortic aneurysm repair presented to our emergency department with right flank pain and anuria resulting from right artery occlusion. His serum creatinine on admission was 7.5 mg/dL.

Association Between ABO Blood Group System and COVID-19 Severity.

Objectives: A possible association between blood group systems (ABO and Rh) and coronavirus disease 2019 (COVID-19) severity has recently been investigated by various studies with conflicting results. However, due to variations in the prevalence of the ABO and Rh blood groups in different populations, their association with COVID-19 might be varied as well. Therefore, we conducted this study on Libyan participants to further investigate this association and make population-based data available to the worldwide scientific community.

Radioprotective Effect of Thymoquinone in X-irradiated Rats.

Background: Thymoquinone, has anti-inflammatory, anti-oxidant, and cardio protection properties. This study aimed to evaluate the radioprotective effect of thymoquinone in whole body X-irradiated rats.

Methods: This study conducted on 40 male adult Wistar albino rats randomized into the following groups: Group I: Control rats did not receive thymoquinone or ionizing radiation.

The perceived global impact of the COVID-19 pandemic on doctors' medical and surgical training: An international survey.

Introduction: The COVID-19 pandemic has resulted in a significant burden on healthcare systems causing disruption to the medical and surgical training of doctors globally.

Aims And Objectives: This is the first international survey assessing the perceived impact of the COVID-19 pandemic on the training of doctors of all grades and specialties.

Methods: An online global survey was disseminated using Survey Monkey between 4th August 2020 and 17th November 2020.

Knowledge, preventive behavior and risk perception regarding COVID-19: a self-reported study on college students.

Introduction: There are a limited number of studies on the issues associated with the knowledge and self-practice preventive measures for COVID-19 among medical students. We aimed to determine the extent of knowledge, self-reported preventive behavior, and risk perception of the COVID-19 outbreak among college students in Libya.

Methods: A cross-sectional study was conducted from April 20 to April 30, 2020.

Telemedicine Awareness, Knowledge, Attitude, and Skills of Health Care Workers in a Low-Resource Country During the COVID-19 Pandemic: Cross-sectional Study.

Background: Since the onset of the COVID-19 pandemic, several health care programs intended to provide telemedicine services have been introduced in Libya. Many physicians have used these services to provide care and advice to their patients remotely.

Objective: This study aimed to provide an overview of physicians' awareness, knowledge, attitude, and skill in using telehealth services in Libya.

The Mental Well-Being of Frontline Physicians Working in Civil Wars Under Coronavirus Disease 2019 Pandemic Conditions.

Emergency medical physicians are regarded as essential frontline staff in combating the coronavirus disease 2019 (COVID-19) pandemic. These health-care workers are faced with significant stressors in addition to the usual stress felt in their regular work. Therefore, this study aimed to examine the prevalence of anxiety, depression, and burnout among emergency physicians on the frontline of the COVID-19 pandemic.

Burnout Syndrome Among Hospital Healthcare Workers During the COVID-19 Pandemic and Civil War: A Cross-Sectional Study.

We aimed to determine the prevalence of burnout among hospital healthcare workers in Libya during the coronavirus disease (COVID-19) pandemic and civil war. A cross-sectional study was conducted from April 18 to May 2, 2020 among Libyan healthcare workers. Data on participant characteristics were collected with a specifically designed questionnaire.

Psychological Impact of the Civil War and COVID-19 on Libyan Medical Students: A Cross-Sectional Study.

Objective: We aim to determine the psychological status of medical students during the COVID-19 outbreak and civil war in Libya.

Methods: A cross-sectional study was conducted among medical students from 15 medical schools between April 20 and May 1, 2020. The demographic characteristics, generalized anxiety disorder 7-item (GAD-7) scale, and patient health questionnaire (PHQ-9) results were collected.

Toxicity Profile, Pharmacokinetic, and Drug-Drug Interaction Study of Citalopram and Sertraline Following Oral Delivery in Rat: An LC-MS/MS Method for the Simultaneous Determination in Plasma.

The burden of depression and other mental disorders is on the rise globally, and successful treatment sometimes requires modifications of drugs and/or dose regimens. The development of novel analytical methods for the determination of antidepressant drugs in biological fluids is thus urgently required. Herein, a sensitive, robust, and rapid liquid chromatographic coupled tandem mass spectrometric method was developed and validated for the determination of citalopram (CIT) and sertraline (SER) in rat plasma after oral administration.

Psychological status of healthcare workers during the civil war and COVID-19 pandemic: A cross-sectional study.

Objective: Healthcare workers, particularly those working in departments that provide care for patients with coronavirus disease 2019 (COVID-19), are at a higher risk of this contagious disease than those who work in other departments. The aim of this study was to assess the psychological status of healthcare workers during the COVID-19 outbreak, which has compounded Libya's existing civil war-related problems.

Methods: A multi-center cross-sectional survey on depressive symptoms, anxiety symptoms, and abuse was conducted.

Assessment of the preparedness of obstetrics and gynecology healthcare systems during the COVID-19 pandemic in Libya.

An adequate strategy is urgently required during the COVID‐19 pandemic for screening pregnant women and newborns, increasing infection control measures, and supplying personal protective equipment and hospital equipment.

Neuroprotective effect of epigallocatechin-3-gallate (EGCG) on radiation-induced damage and apoptosis in the rat hippocampus.

Purpose: This study investigated the potential neuroprotective effect of epigallocatechin-3-gallate (EGCG) on radiation-induced cell death and damage in the hippocampus.

Materials And Methods: Adult male Wister rats received oral treatment with EGCG at doses of 2.5 and 5 mg/kg/d for 3 d before 4 Gy γ irradiation.