972 results match your criteria: "Timone University Hospital[Affiliation]"

Background: Percutaneous extracorporeal membrane oxygenation (ECMO) has been developed thanks to the progress in the field of cannulation, but still justifies the presence of an on-site cardiac resuscitation department. Corsica is a French island without an on-site cardiac surgery department.

Aim: To evaluate the percutaneous ECMO programme in Corsica.

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CSNK2B Mutation: A Rare Cause of IGHD.

Clin Endocrinol (Oxf)

December 2024

Aix Marseille Univ, APHM, INSERM, MMG, UMR 1251, La Timone University Hospital, Laboratory of Molecular Biology GEnOPé, Marseille, France.

Objective: Poirier-Bienvenu neurodevelopmental syndrome (POBINDS) is a rare neurodevelopmental syndrome, resulting from germline heterozygous CSNKB2 pathogenic variants. The main presentations are severe epilepsy, delayed psychomotor development, and/or profound intellectual disability. More recently, CSNK2B pathogenic variants have been reported in patients with mild intellectual disability and no history of epileptic symptoms.

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Background: Patients with atopic dermatitis (AD) may discontinue dupilumab owing to dupilumab-induced ocular adverse events (DOAEs) or dupilumab-induced facial redness (DFR).

Objective: To evaluate DOAE and DFR outcomes after switching to tralokinumab or Janus kinase inhibitor (JAKi).

Methods: This retrospective study included 106 patients discontinuing dupilumab because of DOAEs and/or DFR.

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Electrophysiological Monitoring of Asymptomatic Transthyretin Mutation Carriers.

Muscle Nerve

December 2024

Referral Centre for Neuromuscular Diseases and ALS, La Timone University Hospital, Aix-Marseille University, ERN Neuro-NMD, Marseille, France.

Introduction/aims: It is imperative to screen asymptomatic carriers of transthyretin (TTR) mutations to initiate treatment early. The protocol for repeated electrodiagnostic (EDX) assessments over time lacks standardization. Our aim was to report the electrophysiological evolution of a cohort of asymptomatic carriers and to determine which biomarkers were most sensitive to change.

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Purpose: To investigate the influence of germline succinate dehydrogenase (SDHx) pathogenic variants on 6-[F]-fluoro-3,4-dihydroxyphenylalanine (F-DOPA) Positron Emission Tomography (PET) radiomic signature of head and neck paragangliomas (HNPGLs).

Methods: Forty-seven patients (20 SDH pathogenic variants carriers) harboring 55 HNPGLs were retrospectively included. HNPGLs were delineated using Nestle adaptive threshold.

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Reply to Nathan Milliot, Jérome Jeudy, Nicolas Bigorre: metal hypersensitivity in trapeziometacarpal arthroplasty: a systematic pattern of progression.

Hand Surg Rehabil

December 2024

Department of Hand Surgery and Limb Reconstruction, Timone University Hospital, 278, rue St-Pierre, 13005 Marseille, France; Faculty of Medical Science, AixMarseille University, 27, Boulevard Jean-Moulin, 13005 Marseille, France.

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Article Synopsis
  • The treatment of advanced chondrosarcoma, which often doesn't respond well to standard chemotherapy, is currently being explored through targeted therapies aimed at specific genetic mutations and signaling pathways.
  • New strategies include utilizing IDH inhibitors for tumors with IDH mutations, hedgehog pathway inhibitors, and various forms of immunotherapy, all facing challenges but showing potential for effectiveness.
  • There's a strong emphasis on using personalized, multi-omics approaches to create combination therapies that can better address the heterogeneous nature of chondrosarcoma and possibly improve treatment outcomes.
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Epidemiology of stroke in France.

Arch Cardiovasc Dis

December 2024

Santé Publique France, 94410 Saint-Maurice, France.

Article Synopsis
  • The study reviews the management and outcomes of stroke cases in France, revealing significant data from the year 2022 after nearly a decade of a national stroke plan.
  • In total, 122,422 adults were hospitalized for stroke, with stark variations in care based on geographic and socioeconomic factors, and low rates of advanced treatments like mechanical thrombectomy.
  • The findings indicate high mortality rates within a year post-stroke and call for improved prevention strategies, better public awareness of stroke symptoms, and enhanced accessibility to stroke care services.
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Sportsman's Hernia repair using Nesovic procedure, a 13-year single-center experience.

Updates Surg

December 2024

Department of Digestive Surgery, Aix Marseille Univ, APHM, Timone University Hospital, 264 rue Saint-Pierre, 13005, Marseille, France.

Sportsman's hernia is very frequent in some sports, particularly in football. This painful syndrome is reported by high-level athletes as well as amateurs. There is no consensus about the management of sportsman's hernia, because of the heterogeneity in anatomoclinic forms.

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Background And Objectives: Intramuscular fat fraction (FF), assessed using quantitative MRI (qMRI), has emerged as a promising biomarker for hereditary transthyretin amyloidosis (ATTRv) patients. Currently, the main drawbacks to its use in future therapeutic trials are its sensitivity to change over a short period of time and the time-consuming manual segmentation step to extract quantitative data. This pilot study aimed to demonstrate the suitability of an Artificial Intelligence-based (AI) segmentation technique to assess disease progression in a real-life cohort of ATTRv patients over 1 year.

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Aim: To evaluate the effectiveness of a Bayesian adaptive dosing strategy in achieving target busulfan exposure in adult patients undergoing haematopoietic cell transplantation (HCT).

Methods: This study included 71 adult patients scheduled to receive high-dose busulfan. Busulfan was administered to achieve a cumulative area under the curve (AUC) of 66.

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Introduction: In the beginning of November 2023, the authors launched a neurosurgery department in Nouméa, New Caledonia. Emergency cranial surgeries are performed by orthopedic surgeons. All other cases are transferred to Australia or mainland France.

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Comparison of surgical management and outcomes of acute right colic and sigmoid diverticulitis: a French national retrospective cohort study.

Tech Coloproctol

November 2024

Department of Digestive, Oncological, Endocrine, Hepato-Biliary and Pancreatic Surgery, and Liver Transplantation, Colorectal Surgery Unit, Trousseau Hospital, University Hospital of Tours, Avenue de la République, 37044, Tours, France.

Background: Acute right colic diverticulitis (ARD) is less frequent in Western countries than acute sigmoid diverticulitis (ASD). We aimed to compare the management of ARD and ASD operated on in emergency.

Methods: All consecutive patients who had emergency surgery for ASD and ARD (2010-2021) were included in a retrospective, multicenter, cohort study.

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LIPOPULP. The impact of fat grafting on pulp sensitivity in fingertip injuries: A retrospective study of seven patients.

Ann Chir Plast Esthet

November 2024

Department of Hand Surgery and Plastic and Reconstructive Surgery of the Limbs, La Timone University Hospital, Assistance publique-Hôpitaux de Marseille, Marseille, France. Electronic address:

Objective: This study analyzes the impact of fat grafting on pulp sensitivity disorders in patients who experienced fingertip injuries and developed cold intolerance and hyperesthesia.

Material/method: Patients over 10 years old were evaluated using the two-point discriminant score (2PDS), the monofilament test, and the McCabe Cold Sensitivity Severity Scale (CSS) before and after surgery at 3, 6, and 12 months. Other evaluations included the Quick Dash scale (Q-dash), the aesthetics and pain improvement, and patient satisfaction.

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Article Synopsis
  • The study aims to assess how socioeconomic deprivation affects postoperative outcomes in patients who have undergone surgery for sigmoid diverticulitis (SD).
  • Conducted across 41 French hospitals from 2010 to 2021, researchers found that 20% of the 6,415 patients experienced severe complications within 90 days post-surgery.
  • Results indicated that higher levels of socioeconomic deprivation are linked to an increased risk of severe complications, even after adjusting for factors like age, sex, and surgery type.
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Tracking myasthenia gravis severity over time: Insights from the French health insurance claims database.

Eur J Neurol

January 2025

Neurology and Neuromuscular Diseases Department, Neuromuscular Reference Centre AOC, Pellegrin Hospital, Bordeaux University Hospitals, Bordeaux, France.

Background And Purpose: Few data are available on the course of myasthenia gravis (MG) regarding disease severity and stability over time in real-world settings. This study used the French National Health Insurance Database (SNDS) to assess markers of disease severity in patients with MG longitudinally.

Methods: All patients with MG-related claims in the SNDS between 2013 and 2020 were identified.

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High risk of long-term recurrence after a first episode of venous thromboembolism during pregnancy or postpartum: the REcurrence after a PrEgnAncy related Thrombosis (REPEAT) Study.

J Thromb Haemost

October 2024

Hematology Laboratory, La Timone University Hospital of Marseille, Aix-Marseille University, INSERM 1263, INRAE 1260, C2VN, Marseille, France; Service de médecine vasculaire et Hypertension Artérielle, Faculté de Médecine de Marseille, Aix-Marseille Université, Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone, Marseille, France. Electronic address:

Article Synopsis
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Article Synopsis
  • Hematological involvement (HI) is a serious condition associated with Langerhans cell histiocytosis (LCH), and is defined by low blood cell counts indicating potential life-threatening complications.
  • A study of 2,313 children with LCH revealed that about 331 developed HI, with a distinction between mild (MHI) and severe HI (SHI), each showing different health outcomes and survival rates over 10 years.
  • Recent advances in treatment have improved mortality rates, particularly with combination therapies and targeted treatments, sparking discussions about refining HI definitions to better inform treatment strategies.
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Impact of non-ionising radiation of male fertility: a systematic review.

Fr J Urol

October 2024

Laboratory of Reproductive Biology - CECOS, Fertility Clinic of La Conception University Hospital of Marseille, 147, boulevard Baille, 13005 Marseille, France; Aix Marseille University, Avignon University, CNRS, IRD, IMBE, Marseille, France; Plateforme CREER, La Conception University Hospital of Marseille, 147, boulevard Baille, 13005 Marseille, France. Electronic address:

Exposure to non-ionizing radiation has become inevitable because people cannot escape sources of electromagnetic fields, such as Wi-Fi or cell phones. Among the mechanisms mentioned, the energy emitted by this non-ionizing radiation could cause heating which would have harmful effects on semen quality. The objective of our study was to carry out a systematic review of the literature concerning the impact of exposure to non-ionizing radiation from mobile phones (or other sources) on sperm parameters.

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Comparison of Manual vs Artificial Intelligence-Based Muscle MRI Segmentation for Evaluating Disease Progression in Patients With CMT1A.

Neurology

November 2024

From the Reference Center for Neuromuscular Diseases and ALS (E.F., E.D., S.A.), La Timone University Hospital, Marseille; UMR CNRS 7339 (E.F., C.P.M., M.G., D.B.), Center for Magnetic Resonance in Biology and Medicine, Marseille; CNRS, LIS (M.A.H., M.-E.B.), UMR 7286, Medicine Faculty (E.D.), and Inserm, GMGF (S.A.), Aix-Marseille University, France.

Article Synopsis
  • The study evaluated an AI-based system for automatically segmenting muscles in CMT1A patients using quantitative MRI (qMRI), aiming to streamline the assessment of intramuscular fat fraction (FF) over one year.
  • Results showed that AI segmentation accurately matched manual segmentation techniques, demonstrating significant FF progression in both thigh and leg muscles.
  • The AI approach significantly reduced analysis time from 90 hours to just 10 hours, making it a promising tool for future therapeutic trials in CMT1A research.
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