Assessment of photoreceptor recovery and visual function utilizing adaptive optics and microperimetry in patients with surgically closed macular holes.

Background: This study investigated the association between photoreceptor structural restoration and visual function outcomes in patients undergoing surgery for closed macular holes (MHs). Using adaptive optics scanning laser ophthalmoscopy (AOSLO) and microperimetry, we aimed to provide a more detailed understanding of photoreceptor recovery and visual improvement in closed MHs.

Methods: We conducted a retrospective observational study of 31 eyes of 28 patients who underwent vitrectomy with internal limiting membrane (ILM) peeling to treat idiopathic MHs.

ROS scavenging and corneal epithelial wound healing by a self-crosslinked tissue-adhesive hydrogel based-on dual-functionalized hyaluronic acid.

Reactive oxygen species (ROS) scavenging is a viable approach to promote corneal epithelium wound healing. This study created a single-component hydrogel (HA Gel) with a novel dual-functionalized hyaluronic acid derivative (HA-GA-PBA) containing gallol and phenylboronic acid (PBA) moieties. Both of these moieties were dual-functional.

Chameleon-inspired molecular imprinted polymer with bicolored states for visual and stable detection of diethylstilbestrol in water and food samples.

A novel biomimetic molecular imprinted polymer chip with fluorescence (FL) and structural (STR) states, inspired by color patterns of chameleon skin, is fabricated for detecting diethylstilbestrol (DES). The chip features a regularly structured, non-closed-packed (NCP) colloidal photonic crystal (CPC) lattice made monodisperse MIP spheres containing fluorescence poly ionic liquid (FPIL) pigments. The FL color originates from FPIL pigments and is further enhanced by the Purcell effect, while the STR color results from the periodic arrangement of the NCP CPC structure.

Application of Subretinal Balanced Salt Solution Injection: A Novel technique in treating Severe idiopathic Epiretinal Membrane.

Purpose: To describe a novel surgical approach for treating patients diagnosed with severe idiopathic epiretinal membranes (iERM) featuring ectopic intrafoveal layers (EIFL).

Method: A retrospective, interventional case series was conducted involving eight cases of iERM with EIFL. The technique involved a 27-gauge vitrectomy, removal of all vitreous adhesions, and injection of approximately 100μl sub-retinal balanced salt solution (BSS) using a 41-gauge subretinal needle, creating 3-4 localized bleb-like elevations around the folded retina to loosen it.

Risk factors for diabetic retinopathy in young and middle-aged patients: a retrospective study.

Aims/introduction: To investigate the related risk factors of retinopathy in young and middle-aged diabetic patients in order to improve the prognosis of patients.

Materials And Methods: Using clinical practice data from a cohort study at our two research centers, we developed a bivariate logistic regression model to investigate the frightening risk factors potentially for retinopathy in young and middle-aged patients with diabetes, including diabetes type, physical activity level, treatment-related characteristics and laboratory tests.

Results: A total of 453 patients with diabetes were investigated, 197 (43.

Validation and repeatability assessment of the Chinese version of the Ocular Surface Disease Index (OSDI), 5-item dry eye (DEQ-5), and contact lens dry eye questionnaire-8 (CLDEQ-8) questionnaires.

Purpose: This prospective study aimed to validate the translated Chinese versions of the Ocular Surface Disease Index (OSDI), 5-Item Dry Eye (DEQ-5), and Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) questionnaires and test their repeatability.

Methods: From August 2022 to July 2023, online (qualtrics.com) English and Chinese versions of OSDI, DEQ-5, and CLDEQ-8 questionnaires were distributed to residents of Hong Kong, mainland China, Taiwan, and Singapore ≥ 18 years old who could understand both written Chinese and English.

[Expert consensus on endoscopic surgery for the pediatric middle ear cholesteatoma based on the classification of cholesteatoma location].

Pediatric middle ear cholesteatoma is an aggressive keratotic lesion caused by abnormal proliferation of keratinised squamous epithelium in the temporal bone, with the characteristics of high postoperative recurrence rate, poor hearing effect and poor quality of life. Endoscopic surgery is able to deal with the majority of pediatric middle ear cholesteatoma cases with the features of minimal trauma and wide surgical field. However, endoscopic surgical treatment still has problems in standardization.

Developing the biomarker panels and drugs by proteomic analysis for autoimmune uveitis and posterior scleritis.

Autoimmune uveitis and posterior scleritis are ocular diseases caused by immune dysregulation. Their pathogenesis remains elusive, and delayed diagnosis can exacerbate vision loss. Our study analyzed proteomic profiles of 190 patients with Behcet's disease uveitis, posterior scleritis, and Vogt-Koyanagi-Harada syndrome.

A case of Saturday night retinopathy following postoperative orbital compression bandaging: Diagnosis and evaluation using multimodal imaging.

We report a rare case of Saturday Night Retinopathy (SNR) following postoperative orbital compression bandaging, highlighting the value of multimodal imaging in diagnosis and management. A 24-year-old male underwent surgical repair of an inferior orbital wall fracture with an absorbable implant, followed by compression bandaging of the right eye for three days. Upon bandage removal, the patient experienced a significant drop in visual acuity (VA) from 20/20 to 20/200.

Optical quality changes of the eye during peak SARS-CoV-2 pandemic in young adults.

Introduction: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects corneal morphology and optical quality.

Methods: In this cross-sectional study, ophthalmological indicators were examined during the peak of SARS-CoV-2 infection after adjusting for public health control measures. Participants were divided into control (remained uninfected), A (infected during follow-up), and B (infected prior to the first consultation) groups.

Kirigami Design Smart Contact Lens for Highly Sensitive Eyelid Pressure Measurement.

Eyelid pressure is a crucial biomechanical parameter for ocular health and refractive status, yet measuring it poses challenges related to flexibility, sensitivity, and regional specificity. This study introduces a novel smart contact lens that incorporates kirigami designs and an iontronic capacitive sensing array to enhance flexibility and conformability. The unique structural composition of this device allows for precise and simultaneous monitoring of eyelid pressure in multiple regions with a high sensitivity and seamlessly fit across corneal curvatures.

Linking Iris Cis-Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics.

Purpose: To elucidate the genetic basis of primary angle-closure glaucoma (PACG) by identifying pathogenic tissue and critical tissue-specific variants.

Methods: The correlations among PACG susceptibility, axial length (AL), and anterior chamber depth (ACD) were evaluated using meta-analyses. Propensity score matching was utilized on 2161 participants from the Handan Eye Study to determine the risk factors independent of ACD and AL for PACG.

Causal association between glaucoma and risk of retinal vascular occlusion: a Mendelian randomization study.

Objective: Retinal vein occlusion (RVO) leads to visual impairment, and risk factors may include glaucoma. Although some studies suggest a relationship between glaucoma and RVO, it is unknown whether this association is causal. We performed Mendelian randomization (MR) analyses to evaluate the causal contribution to RVO of five genetically predicted glaucoma conditions.

Unveiling the Mysteries of the Chinese lens zonule balance tension: A statistical analysis.

Background: This study aims to provide an estimated dataset of lens zonule balance tension (LZBT) measurements in cataractous lenses among Chinese patients and to conduct a statistical analysis of anterior segment parameters.

Methods: This is a cross-sectional study. We included a total of 833 eyes from 833 Chinese participants aged 23-91 years who underwent cataract surgery.

The potential role of the SIRT1-Nrf2 signaling pathway in alleviating hidden hearing loss via antioxidant stress.

Hidden hearing loss (HHL) is characterized by normal audiometric thresholds but impaired auditory function, particularly in noisy environments. In vivo, we employed auditory brainstem response (ABR) testing and ribbon synapses counting to assess changes in mouse hearing function, and observed the morphology of hair cells through scanning electron microscopy. SRT1720 was administered to the cochlea via round window injection.

Microcirculatory parameters as risk factors for predicting progression of posterior staphyloma in highly myopic eyes: a case-control study.

Background: To assess the rate of macular blood flow decreasing in adults with and without posterior staphyloma (PS) using optical coherence tomography angiography (OCTA) and to identify risk factors associated with PS progression.

Methods: This longitudinal case-control study enrolled 122 eyes of 122 patients-64 patients with PS (PS group) and 58 patients without PS (NPS group). Participants underwent OCTA and clinical examinations at least twice, and those followed for at least one year were included in the analysis.

[Effect and differentiation of spontaneous nystagmus of acute unilateral vestibulopathy on saccade in the video head impulse test].

Exploring the performance characteristics of spontaneous nystagmus（SN） in video-head impulse test（vHIT） and its possible effects on saccade. Vestibular function tests such as vHIT and SN were conducted in 48 patients with acute unilateral vestibulopathy（AUVP）. The saccade characteristics of vHIT in patients without SN and those with SN were analyzed, as well as the expression characteristics of SN in vHIT.

Comparison of therapeutic effects of 0.05% Cyclosporine A versus 0.1% Fluorometholone in Chinese patients with mild dry eye unresponsive to artificial tears: a randomized control study.

Background: To assess and compare the therapeutic outcomes of 0.05% Cyclosporine A (CsA) ophthalmic solution versus 0.1% Fluorometholone (FML) eyedrops in Chinese patients with mild dry eye disease (DED) unresponsive to conventional artificial tears (AT).

Analysis of the spatio-temporal evolutionary characteristics of myopia among students aged 7-18 years in China: based on panel data analysis.

Myopia is a major important public health concern and has huge burden on health system across the world. This study aimed to explore the spatial and temporal analysis of the prevalence of myopia among students aged 7-18 years to identify the potential clusters and the trends of myopia in China. Spatial autocorrelation analysis, temporal and spatial scan analysis and beta convergence test were performed using ArcGIS10.

Evidence-based Guidelines for Keratorefractive Lenticule Extraction Surgery.

Topic: Development of evidence-based guidelines for keratorefractive lenticule extraction (KLEx).

Clinical Relevance: KLEx refers to various corneal refractive procedures involving removal of refractive lenticules of intrastromal corneal tissue, typically through a small incision, thereby eliminating creation of a corneal flap. This technique has rapidly gained popularity as a possible alternative to flap-based procedures; however, no clinical practice guidelines exist for KLEx.