INTRAVITREAL CONBERCEPT (KH902) FOR SURGICAL TREATMENT OF SEVERE PROLIFERATIVE DIABETIC RETINOPATHY.

Purpose: To evaluate the role, safety, and effectiveness of intravitreal conbercept (KH902) injections as an adjunct to vitrectomy in the management of severe proliferative diabetic retinopathy.

Methods: A randomized controlled trial was performed on 36 eyes of 36 patients affected by vitreous hemorrhage and tractional retinal detachment, which occurred as a consequence of active proliferative diabetic retinopathy. The patients were randomly assigned to two groups.

Complement anaphylatoxin receptors C3aR and C5aR are required in the pathogenesis of experimental autoimmune uveitis.

Recent studies have suggested that reagents inhibiting complement activation could be effective in treating T cell mediated autoimmune diseases such as autoimmune uveitis. However, the precise role of the complement anaphylatoxin receptors (C3a and C5a receptors) in the pathogenesis of autoimmune uveitis remains elusive and controversial. We induced experimental autoimmune uveitis in mice deficient or sufficient in both C3a and C5a receptors and rigorously compared their retinal phenotype using various imaging techniques, including indirect ophthalmoscopy, confocal scanning laser ophthalmoscopy, spectral domain optical coherence tomography, topical endoscopic fundus imaging, and histopathological analysis.

Comparison of Artisan iris-claw intraocular lens implantation and posterior chamber intraocular lens sulcus fixation for aphakic eyes.

Aim: To compare the efficacy and complications of Artisan iris-claw intraocular lens (IOL) implantation and posterior chamber IOL sulcus fixation for the treatment of aphakic eyes without capsular support after vitrectomy.

Methods: A prospective study of 45 cases was conducted. Forty-five eyes without sufficient lens capsule support following pars plana vitrectomy (PPV) combined lens extraction were divided into two groups.

[Current progress in capsular contraction syndrome].

With the progress of cataract surgery skills, continuous capsulorhexis as an ideal technology is widely applied to phacoemulsification. However capsular contraction syndrome is a phenomenon after the continuous capsulorhexis technology was applied. It can affect visual quality, the observation of fundus, cause lens dislocation, etc.

[Potential applications of mesenchymal stem cells in ocular diseases].

Except for the characteristics of stem cells, mesenchymal stem cells (MSC) have other distinct functions such as prompting wound healing, anti-inflammatory and immunoregulatory ability, which has made them one of the most promising candidates for cell therapy. By taking advantage of their different characteristics and functions, MSC have been exploited in the treatment of many ocular diseases, such as corneal diseases, uveitis and retinal diseases. This paper will review the progress of the applications of MSC in ocular diseases in recent years.

[Expression and function of microRNA in the eye].

MicroRNA (miRNA), about 22 nt in length, are small single-strand RNA discovered in recent years that universally exist in the genome of creatures. They control physiological and pathological processes through regulation of gene expression at either posttranscriptional or translational level. Hundreds of miRNA have been confirmed to express in ocular tissues, and function as important regulators in physiological processes, including development, differentiation, regeneration after injury, as well as control of circadian rhythms in the eye.

[Overexpression of the receptor tyrosine kinase EphA2 in choroidal melanoma: correlation with vesculogenic mimicry and prognosis].

Objective: To study the correlation of EphA2 protein expression with vesculogenic mimicry (VM), clinicopathological characteristics and prognosis in choroidal melanoma (CM).

Methods: It was a retrospective case series study. Between January 1992 and December 2005, 56 cases of human CM with clinicopathologic data from the Second Hospital of Tianjin Medical University were studied.

[Clinical research of the phakic foldable angle-supported intraocular lens for the correction of high myopia].

Objective: To assess the safety, efficacy, predictability and stability of the phakic foldable angle-supported intraocular lens (IOL) (CACHET IOL, Alcon Inc., USA.) for correction of high-to-extremely high myopia in adults.

[Investigation of the role of mesenchymal stem cells on keratoplasty rejection].

Objective: To investigate the effect of mesenchymal stem cells (MSC) on keratoplasty rejection in a rat mode.

Methods: MSC from bone marrow of Wistar rats was cultured. Corneas of Wistar rats (donors) were transplanted to Lewis rats (recipients).

[Research status of photodynamic therapy for corneal neovascularization].

Pathological corneal neovascularization is an important reason of visual impairment. Research outcomes showed that angiogenesis mechanism is similar in all the tissues of the body and photodynamic therapy demonstrate a useful effect in blocking tumor and choroidal neovascularization. This method is currently being tried for the treatment of corneal neovascularization.

The tear film characteristics of spontaneous subconjunctival hemorrhage patients detected by Schirmer test I and tear interferometry.

Purpose: To evaluate the tear film characteristics of spontaneous subconjunctival hemorrhage patients by Schirmer test I and tear interferometry.

Methods: Forty-six spontaneous subconjunctival hemorrhage patients and 46 controls were enrolled in the study. Schirmer test I and tear interferometry were performed in all 92 subjects.

Immunomodulatory effects of mesenchymal stem cells in a rat corneal allograft rejection model.

Mesenchymal stem cells (MSCs) are promising candidates for immunomodulatory therapy that are currently being tested in several organ transplant rejection models. In this study, we tested the immunomodulatory effects of MSC injection in a rat model of corneal allograft rejection. MSCs were isolated and cultured from bone marrow of Wistar rats.

[Clinical study of functional vision changes after +3.00 D aspheric AcrySof ReSTOR intraocular lens implantation].

Objective: To evaluate the visual outcome of +3.00 D aspheric intraocular lens (IOL) implantation and compare it with the previous +4.00 D aspheric AcrySof ReSTOR multifocal IOL.

AcrySof phakic angle-supported intraocular lens for the correction of high to extremely high myopia: one-year follow-up results.

Aim: To assess the safety, efficacy and predictability of the AcrySof phakic angle-supported intraocular lens (IOL) (Alcon Inc., U.S.

[The progress of aqueous humor outflow pathway in open-angle glaucoma].

Primary open angle glaucoma (POAG) is defined as an optic neuropathy characterized by loss of optic nerve axons and retinal ganglion cells. Increase of intraocular pressure (IOP) is a major risk factor for POAG, which is partially due to an abnormally high aqueous humor outflow resistance in trabecular meshwork (TM). Trabecular outflow pathway is a key element in drainage of aqueous humor.

[Characters of multifocal electroretinogram in different grades of diabetic macular edema].

Objective: To investigate the characters of multifocal electroretinogram (mfERG) in different grades of diabetic macular edema defined by optical coherence tomography (OCT).

Methods: MfERG and OCT were performed in 57 eyes of diabetic macular edema (DME) patients and 35 eyes of the control group. According to the macular thickness measured by OCT, eyes with DME were divided into three groups: mild, moderate and severe DMEs.

[Analysis of expression of cancer stem cell-related markers in orbital adenoid cystic carcinoma].

Objective: To observe the expression and distribution of CD44, CD133, and ABCG2 in orbital adenoid cystic carcinoma (ACC) and investigate their correlations with pathological type and prognosis.

Method: Two steps method of immunohistochemical staining was employed in 33 cases of paraffin embedded surgical specimens of human orbital ACC, 5 cases of recurrence samples, 3 cases of an excised lacrimal gland caused by neither inflammation nor tumor diseases, and 6 cases of xenograft tumors in nude mice. A retrospective analysis was performed on the clinical material of these patients, which were collected from Jan.

A simultaneous iris angiography technique in pigmented rabbits.

Purpose: To report a simultaneous iris angiography (IA) technique combined with the use of indocyanine green (ICG) and fluorescein sodium (FS) in pigmented rabbits.

Methods: 15 rabbits were randomly divided into 3 groups according to the dye doses: the dose of the lower-volume group was 2 mg FS and 2 mg ICG; the dose of the moderate-volume group was 5 mg FS and 5 mg ICG, and the dose of the higher-volume group was 8 mg FS and 8 mg ICG. Fifteen IAs were performed by a confocal scanning laser ophthalmoscope and a rapid localization technique giving a flat-on image.

Comparison of disposable sutureless silicone ring and traditional metal ring in 23-gauge vitrectomy combined with cataract surgery.

Background: The purpose of this prospective, interventional, comparative case series was to evaluate the efficiency and feasibility of a disposable sutureless silicone lens ring for corneal contact lens stabilization during combined 23-gauge vitrectomy and cataract surgery.

Methods: We developed a ring consisting of a single silicone component with three footplates along the ring margin to fit cannulae for holding conventional contact lenses. Thirty eyes from 30 patients with cataract and vitreoretinal disease were included, and divided into two matched groups according to disease type and ring used.

[In vivo high-resolution imaging of rat retina with optical coherence tomography and the expression of Bcl-2, Bax, Caspase-3 mRNA during critical period plasticity].

Objective: To observe the changes of retinal thickness during critical period plasticity in rat, and to investigate whether apoptosis participates in the structural forming of retina.

Methods: Experimental research. 50 normal newborn pups of SD rat were randomly selected in the experiment.

MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme.

Aberrant expression of microRNAs (miRNAs) has been implicated in cancer initiation and progression. In this study, we found that microRNA-34a (miR-34a) is significantly downregulated in glioblastoma multiforme (GBM) specimens compared with normal brain tissues. Growth curve and colony formation assays revealed that miR-34a suppresses proliferation of U373MG and SHG44 glioblastoma cells.

Research progress on siRNA delivery with nonviral carriers.

RNA interference is a powerful method for the knockdown of pathologically relevant genes. Small interfering RNAs (siRNAs) have been widely demonstrated as effective biomedical genetic-therapy applications for many diseases. Unfortunately, siRNA duplexes are not ideal drug-like molecules.

[The changes of bioactive substances in the aqueous humor of Pseudoexfoliation syndrome].

Pseudoexfoliation syndrome, which represents the most commonly identified specific cause of open-angle glaucoma, is a kind of clinically systemic disease. Why there are so much exfoliative material deposited in the anterior chamber? Where did exfoliative material come from? The pathogenesis is never be confirmed exactly, though there are so many theories described by investigators. In recent years, in order to survey and evaluate the changes of the materials of the aqueous humor of patients with the Pseudoexfoliation syndrome, many investigators had done more works.

Giant Merkel cell carcinoma of the eyelid: a case report and review of the literature.

Merkel cell carcinoma (MCC) is a rare cutaneous tumor and cases located in the eyelid have been described, but still its rarity may lead to difficulty in diagnosis and delay in treatment. A 51-year-old female patient that presented with large lesions in the eyelid underwent surgery after the diagnosis of acute chalazion. Following respiratory distress secondary to pulmonary metastasis, the patient's condition deteriorated and was not fit for complete excision treatment.