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[The application value of plasma heterogeneous nuclear ribonucleoprotein A2/B1, Aβ and P-tau in the preoperative diagnosis of mild cognitive dysfunction].

Zhonghua Yi Xue Za Zhi

February 2022

Tianjin Third Central Hospital, Third Central Hospital of Tianjin Affiliated to Nankai University, Third Central Clinical College of Tianjin Medical University, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Tianjin Hepatobiliary Disease Research Institute, Tianjin 300170, China.

To explore the application value of plasma heterogeneous nuclear ribonucleoprotein A2/B1(hnRNP A2B1), β-amyloid 42(Aβ) and phosphorylated tau protein(P-tau) levels in elderly patients in the preoperative diagnosis of mild cognitive impairment(MCI). A total of 200 patients who underwent elective surgery at Tianjin Third Central Hospital from June 2020 to March 2021were Enrolled, regardless of gender, age 65-80 years old. According to the international MCI working group standards and the European Alzheimer's Disease Federation working group standards, patients were divided into MCI group and control group.

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