898 results match your criteria: "Tianjin Eye Hospital[Affiliation]"
Int J Ophthalmol
August 2024
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Aim: To explore the prognostic factors for lacrimal gland adenoid cystic carcinoma (LGACC) in Chinese patients.
Methods: Clinical and histopathological data were reviewed in patients with pathologically confirmed LGACC. Local recurrence, metastasis, and disease-specific death were the main outcome measures.
Exp Eye Res
October 2024
School of Medicine, Nankai University, Tianjin, 300071, China; Nankai University Affiliated Eye Hospital, Tianjin, 300020, China; Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Tianjin, 300020, China; Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, 300020, China. Electronic address:
Purpose: Benzalkonium chloride (BAC) is commonly used as a preservative in ophthalmic medications, despite its potential to induce chemical injury. Extensive research has demonstrated that BAC can lead to adverse effects, including injuries to the ocular surface. Our study aimed to elucidate the underlying mechanism of necroptosis induced by BAC.
View Article and Find Full Text PDFZhonghua Yan Ke Za Zhi
August 2024
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China.
With the population aging, the increasing number of presbyopia patients and the growing demand for correction have become pressing visual challenges. In recent years, presbyopia correction surgery has been a clinical focus, with ongoing innovations in surgical mechanisms and methods, but significant issues remain unresolved. This article explores the advancements and challenges in various presbyopia correction procedures, identifies key future trends and directions, and aims to provide guidance for improving the safety, efficacy, practicality, and longevity of these procedures in line with natural aging processes.
View Article and Find Full Text PDFJ Clin Nurs
July 2024
School of Nursing, Tianjin Medical University, Tianjin, China.
Aim: The aim of this study was to investigate self-care behaviours of patients with chronic obstructive pulmonary disease (COPD), understand their complex interconnections and identify key behaviours influencing self-care and self-efficacy.
Design: An observational, cross-sectional study design.
Setting(s): The outpatient department of two tertiary hospital.
Heliyon
June 2024
Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, 300020, China.
Dry age-related macular degeneration (AMD) is one of the main diseases that causes blindness in humans, and the number of cases is increasing yearly. However, effective treatments are unavailable, and arbutin (ARB) has been reported to have antioxidant, anti-inflammatory, and anti-aging effects in other age-related diseases. However, whether ARB can be used to treat dry AMD remains unknown.
View Article and Find Full Text PDFExp Eye Res
September 2024
Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, PR China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, PR China. Electronic address:
Ocular melanoma, including uveal melanoma (UM) and conjunctival melanoma (CM), is the most common ocular cancer among adults with a high rate of recurrence and poor prognosis. Loss of epigenetic homeostasis disturbed gene expression patterns, resulting in oncogenesis. Herein, we comprehensively analyzed the DNA methylation, transcriptome profiles, and corresponding clinical information of UM patients through multiple machine-learning algorithms, finding that a methylation-driven gene RBMS1 was correlated with poor clinical outcomes of UM patients.
View Article and Find Full Text PDFLipids Health Dis
June 2024
Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, PR China.
Background: An imbalance in lipid metabolism has been linked to the development of AMD, but the causal relationship between AMD and plasma fatty acids (FAs) remains controversial. Using a two-sample Mendelian randomization (MR) approach, we sought to evaluate the impact of specific FA plasma levels on the risk of different AMD subtypes.
Methods: We analysed genome-wide association data of circulating FAs from 115,006 European-descended individuals in the UK Biobank.
Int Ophthalmol
June 2024
Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Afliated People's Hospital of Northwest University, Xi'an, 710004, China.
Purpose: To investigate the clinical significance of the correlation between optical densitometry and both biomechanical and morphological parameters in keratoconus (KC) and to verify the diagnostic value of optical densitometry in KC.
Method: This cross-sectional study included 436 eyes of 295 patients with KC. Corneal optical densitometry, morphological parameters and biomechanical parameters were measured.
Clin Exp Pharmacol Physiol
August 2024
Department of Molecular Pharmacology, School of Medicine, Nankai University, Tianjin, China.
Ophthalmic Physiol Opt
September 2024
Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
Purpose: To conduct a large retrospective study of screening refractive error in young children.
Methods: This retrospective study included children aged from 4 months to 8 years in Daxing District, Beijing, who underwent refractive examinations without cycloplegia. It included a cross-sectional assessment of refractive error screening for all children, and a longitudinal component for a subgroup with data available for two to five visits.
Biol Res
June 2024
Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Hospital, Tianjin, China.
Med Image Anal
October 2024
Nankai University Eye Institute, Nankai University, Tianjin 300350, China; Institute of Robotics and Automatic Information System (IRAIS), the Tianjin Key Laboratory of Intelligent Robotic (tjKLIR), Nankai University, Tianjin 300350, China. Electronic address:
Objective: The development of myopia is usually accompanied by changes in retinal vessels, optic disc, optic cup, fovea, and other retinal structures as well as the length of the ocular axis. And the accurate registration of retinal images is very important for the extraction and analysis of retinal structural changes. However, the registration of retinal images with myopia development faces a series of challenges, due to the unique curved surface of the retina, as well as the changes in fundus curvature caused by ocular axis elongation.
View Article and Find Full Text PDFRetina
June 2024
Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Nankai University Eye Institute, Nankai University, Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
Exp Eye Res
August 2024
Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, 300020, PR China; Tianjin Key Lab of Ophthalmology and Vision Science, Tianjin Eye Hospital, Tianjin, 300020, PR China; Nankai University Eye Institute, Nankai University Affiliated Eye Hospital, Nankai University, Tianjin, 300020, PR China. Electronic address:
This review examines the pivotal role of photoreceptor cells in ocular refraction development, focusing on dopamine (DA) as a key neurotransmitter. Contrary to the earlier view favoring cone cells, recent studies have highlighted the substantial contributions of both rod and cone cells to the visual signaling pathways that influence ocular refractive development. Notably, rod cells appeared to play a central role.
View Article and Find Full Text PDFAdv Sci (Weinh)
August 2024
Tianjin Key Laboratory of Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.
PARP inhibitors (PARPi) hold substantial promise in treating glioblastoma (GBM). However, the adverse effects have restricted their broad application. Through unbiased transcriptomic and proteomic sequencing, it is discovered that the BET inhibitor (BETi) Birabresib profoundly alters the processes of DNA replication and cell cycle progression in GBM cells, beyond the previously reported impact of BET inhibition on homologous recombination repair.
View Article and Find Full Text PDFBiochem Genet
June 2024
Tianjin Eye Hospital, Nankai University Affiliated Eye Hospital, Clinical College of Ophthalmology, Tianjin Medical University, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, 300020, China.
Diabetic cataract (DC) is a major cause of blindness in diabetic patients and it is characterized by early onset and rapid progression. MiR-204-5p was previously identified as one of the top five down-regulated miRNAs in human DC lens tissues. We aimed to determine the expression of miR-204-5p in human lens epithelial cells (HLECs) and explore its effects and mechanisms in regulating the progression of DC.
View Article and Find Full Text PDFBiomed Opt Express
June 2024
Nankai University Eye Institute, Nankai University Affiliated Eye Hospital, Nankai University, 38 Tongyan Road, Haihe Education Park, Tianjin 300350, China.
This study presents the fabrication and evaluation of a sinusoidal extended depth-of-focus (EDoF) intraocular lens (IOL) based on our previously proposed design approach. The power, through-focus MTF, and surface profile were measured using commercial instruments. Through-focus images of a United States Air Force (USAF) 1951 resolution target formed by the fabricated IOL were compared with Symfony and AR40E under monochromatic and polychromatic light using optical bench testing.
View Article and Find Full Text PDFCell Discov
June 2024
Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Conjunctival melanoma (CoM) is a potentially devastating tumor that can lead to distant metastasis. Despite various therapeutic strategies for distant metastatic CoM, the clinical outcomes remain unfavorable. Herein, we performed single-cell RNA sequencing (scRNA-seq) of 47,017 cells obtained from normal conjunctival samples (n = 3) and conjunctival melanomas (n = 7).
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
June 2024
School of Medicine, Nankai University, Tianjin, China; Nankai University Affiliated Eye Hospital, Tianjin, China.
Purpose: Corneal injury (CI) resulting in corneal opacity remains a clinical challenge. Exosomes (Exos) derived from bone marrow mesenchymal stem cells (BMSCs) have been proven effective in repairing various tissue injuries and are also considered excellent drug carriers due to their biological properties. Recently, microRNA-29b (miR-29b) was found to play an important role in the autophagy regulation which correlates with cell inflammation and fibrosis.
View Article and Find Full Text PDFSci Rep
June 2024
School of Medicine, Nankai University, Tianjin, 300071, China.
Keratoconus is corneal disease in which the progression of conical dilation of cornea leads to reduced visual acuity and even corneal perforation. However, the etiology mechanism of keratoconus is still unclear. This study aims to identify the signature genes related to cell death in keratoconus and examine the function of these genes.
View Article and Find Full Text PDFJ Ocul Pharmacol Ther
September 2024
Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
To evaluate the therapeutic efficacy of topical application of a neurokinin-1 receptor (NK1R) antagonist in a rabbit model of nonallergic ocular redness. Nonallergic ocular redness was induced in rabbits by a single, topical application of dapiparzole hydrochloride eye drops (0.5%, 1%, 2%, or 5%).
View Article and Find Full Text PDFZhonghua Yan Ke Za Zhi
June 2024
Tianjin Eye Hospital, Nankai University Affiliated Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin 300020, China.
To explore the changes in gray matter volume of the cerebral cortex in patients with intermittent exotropia (IXT) using the voxel-based analysis and to analyze the correlation between these changes and clinical manifestations. This was a cross-sectional study. A collection of 15 consecutive patients diagnosed with IXT at Tianjin Eye Hospital from March 2021 to May 2022 formed the exotropia group, which comprised 8 males and 7 females, with an average age of (23.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
May 2024
Department of Ophthalmology, Tianjin Medical University General Hospital, Heping District, Tianjin, China.
Background: The primary aim of this study was to investigate the correlation between diabetic retinopathy (DR) and the HALP score (hemoglobin, albumin, lymphocyte, and platelet) in individuals with diabetes within the United States population.
Methods: This cross-sectional investigation was based on the National Health and Nutrition Examination Survey (NHANES) database from 2003-2018. The following module calculated the HALP score: HALP score = [lymphocytes (/L) × hemoglobin (g/L) × albumin (g/L)]/platelets (/L).