2,184 results match your criteria: "Tianjin 300193; Tianjin Acupuncture and Moxibustion Institute[Affiliation]"

[Stuck acupuncture combined with facial acupuncture for 22 cases of facial cosmetology].

Zhongguo Zhen Jiu

January 2025

Department of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of TCM, Tianjin 300193, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193.

Objective: To observe the clinical efficacy of tuck acupuncture combined with facial acupuncture for facial cosmetology.

Methods: A total of 22 female patients with symptoms of facial aging were treated with tuck acupuncture combined with facial acupuncture. Stuck acupuncture was applied at bilateral Taiyang (EX-HN5) through Xiaguan (ST7), Jiache (ST6) through Daying (ST5) and Yingxiang (LI20),once a week.

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Background: Risk factors for bloodstream infection in patients with COVID-19 in the intensive care unit (ICU) remain unclear. The purpose of this systematic review was to study the risk factors for BSI in patients admitted to ICUs for COVID-19.

Methods: A systematic search was performed on PubMed, EMBASE, Cochrane Library, and Web of Science up to July 2024.

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Cuproptosis: A new mechanism for anti-tumour therapy.

Pathol Res Pract

December 2024

First Teaching Hospital, Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193,  China; Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.

As an indispensable trace metal element in the organism, copper acts as a key catalytic cofactor in a wide range of biological processes. Copper homeostasis disorders can be caused by either copper excess or deficiency, and copper homeostasis disorders will affect the normal physiological functions of cells and induce cell death through a variety of mechanisms, such as the emerging cuproptosis model. The imbalance of copper homeostasis will lead to the occurrence of cancer, and copper is a key factor in cell signalling, so copper is involved in the development of cancer by promoting cell proliferation, angiogenesis and metastasis, etc.

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The medicinal fungus Phellinus Igniarius (P. igniarius) has been demonstrated to possess a variety of pharmacological effects, including anti-oxidant, anti-tumor, blood circulation promotion, anti-diarrheal and sedative properties, etc. In order to gain a deeper understanding of the components in P.

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Objective: This study aims to explore the research landscape, hot topics, and future trends of non-pharmacological therapies for post-stroke spastic paralysis globally from 2000 to 2024 through a bibliometric analysis.

Methods: We conducted a search in the Web of Science Core Collection database to analyze literature related to non-pharmacological therapies for post-stroke spastic paralysis published between 2000 and 2024. Tools including CiteSpace, VOSviewer, Bibliometrix, Scimago, and R language were used to identify and analyze countries, institutions, journals, references, keywords, as well as the most commonly used therapies and acupuncture points.

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Background: Blood-brain barrier (BBB) integrity disruption is a key pathological link of diabetes-induced cognitive impairment (DCI), but the detailed mechanism of how the diabetic environment induces BBB integrity disruption is not fully understood. Our previous study found that Zi Shen Wan Fang (ZSWF), an optimized prescription consisting of Anemarrhenae Rhizoma (Anemarrhena asphodeloides Bge.), Phellodendri Chinensis Cortex (Phellodendron chinense Schneid.

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Background: Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory disease in children. Some patients may develop long-term respiratory issues such as chronic cough and wheezing due to complications. These complications increase the health burden for children with MPP, highlighting the need to understand their risk factors in order to improve disease prognosis.

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Constipation is a common and prevalent digestive system disease in clinical practice, which seriously affects human physical and mental health. Currently, chemical drugs have good short-term therapeutic effects. However, because of their adverse reactions, easy recurrence after drug discontinuation, and dependence with long-term use, the long-term efficacy is unsatisfactory.

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The traditional method of acetamiprid residue detection is difficult to operate, time-consuming, laborious and requires high professional knowledge of the detection personnel, which cannot meet the requirement of on-field rapid detection. For this reason, a colorimetric aptasensor based on an entropy-catalyzed amplification system was developed for the ultrasensitive and selective determination of acetamiprid. In the absence of acetamiprid, the aptamer and cDNA form a double-stranded structure.

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High-throughput point-of-care serum iron testing utilizing machine learning-assisted deep eutectic solvent fluorescence detection platform.

J Colloid Interface Sci

February 2025

School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address:

Article Synopsis
  • A high-throughput point-of-care testing (HT-POCT) system was created to rapidly and accurately detect trace serum iron using a machine learning-assisted platform combined with hydrophobic carbon quantum dots (CQDs).
  • The CQDs, which have a quantum yield of 36.6%, are effective for iron ion detection and demonstrate enhanced fluorescence signals when used with hydrophobic deep eutectic solvents (HDESs).
  • The system employs the YOLOv8 algorithm to analyze samples, achieving low limits of detection (33 nM) and consistent results, making it a reliable method for measuring iron concentrations.
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Structural characteristics and potential antidepressant mechanism of a water-insoluble β-1,3-glucan from an edible fungus Wolfiporia cocos.

Carbohydr Polym

January 2025

Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan 430065, China. Electronic address:

A water-insoluble β-1,3-glucan (Wβ) with a molecular weight of 8.12 × 10 Da was extracted from an edible fungus Wolfiporia cocos. Its backbone was composed of 1,3-β-linked Glcp branched at the C-2, C-4, and C-6 positions, connecting more 1,3-β-linked Glcp with a triple helical structure.

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Background: Cnidii Fructus (CF) is a herbal medicine with pharmacological activities such as antitumor, antiviral, antiallergic, antipruritic effects, and so on.

Objective: In this study, an ultra-high performance liquid chromatography/tandem mass spectrometry (UPLC- MS/MS) method was prepared and verified to measure the concentrations of seven analytes (bergapten, xanthotoxol, xanthotoxin, imperatorin, osthole, isopimpinellin, isoimperatorin) in HepG2 cells.

Methods: The separation of seven analytes was performed on an ACQUITY UPLC® BEH C18 column (2.

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Isoprenaline Inhibits Histone Demethylase LSD1 to Induce Cardiac Hypertrophy.

Cardiovasc Toxicol

November 2024

College of Basic Medical Sciences, Tianjin Medical University, 22# Qixiangtai Road, Heping District, Tianjin, 300070, People's Republic of China.

Histone demethylation in cardiac hypertrophy is poorly understood. This study aims to determine the role of the histone demethylase LSD1 in pathological cardiac hypertrophy. Both isoprenaline (ISO)-treated and transverse aortic constriction (TAC)-treated rats developed hypertrophic hearts.

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Acacetin alleviates rheumatoid arthritis by targeting HSP90 ATPase domain to promote COX-2 degradation.

Phytomedicine

December 2024

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China.

Background: Inflammation plays a significant role in initiating and sustaining rheumatoid arthritis (RA). Acacetin, a natural flavonoid compound, exhibits excellent anti-inflammatory effects specifically for RA. However, its relevant targets and molecular mechanisms remain to be elucidated.

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Insulin resistance (IR) is an important risk factor for obesity and cardiometabolic diseases, and our previous findings have demonstrated that visceral fat area to skeletal muscle mass ratio (VSR) is significantly and positively associated with the risk of cardiometabolic diseases. Hence, this study aimed to investigate the relationship between VSR and multiorgan IR, provide a new approach to improve body composition, and set the basis for VSR to increase the incidence of cardiometabolic diseases. The study included 398 patients who underwent anthropometric and biochemical measurements, and body composition assessment.

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Identification of Key Immune and Cell Cycle Modules and Prognostic Genes for Glioma Patients through Transcriptome Analysis.

Pharmaceuticals (Basel)

September 2024

Tianjin Tasly Digital Intelligence Chinese Medicine Development Co., Ltd., Tianjin 300410, China.

Article Synopsis
  • Gliomas are highly aggressive brain tumors, and the study aimed to find prognostic markers related to their clinical traits by analyzing extensive datasets.
  • Using WGCNA and LASSO regression, 11 key genes were identified, leading to the development of a prognostic risk score model that accurately predicts patient outcomes.
  • The research highlights immune system interactions in glioma progression and suggests torin-1 and clofarabine as promising drugs that might effectively target these tumors.
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Article Synopsis
  • Alzheimer's disease (AD) is a significant health challenge with limited treatments, and YangXue QingNao Wan (YXQNW) is a TCM formula being tested for its effectiveness against AD in clinical trials.
  • This study investigates the anti-AD properties of YXQNW through an innovative endophenotype network strategy, identifying active ingredients and clarifying their therapeutic mechanisms.
  • Results show a strong correlation between YXQNW's effects and amyloid β levels, indicating its potential role in addressing AD's pathology.
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Objectives: To observe the effect of "Xingnao Kaiqiao" needling on the expression of ferroptosis-related proteins in neurons of rats with cerebral ischemia-reperfusion injury (CIRI), so as to explore its mechanism underlying improvement of CIRI.

Methods: Male Wistar rats were randomly divided into sham operation, model, acupuncture and deferoxamine (DFO) groups, with 18 rats in each group. The CIRI model was established by occlusion of the middle cerebral artery.

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Deciphering the mechanistic impact of acupuncture on the neurovascular unit in acute ischemic stroke: Insights from basic research in a narrative review.

Ageing Res Rev

November 2024

Department of Acupuncture, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Department of Acupuncture, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China. Electronic address:

Article Synopsis
  • * Treatments like thrombolysis and thrombectomy have strict time limits, and other options like drugs and nanomedicines are not very effective or well-tested.
  • * Acupuncture is a recommended alternative therapy for IS that helps the brain heal in several ways, like improving brain cell health and protecting blood vessels, even though how it works isn’t completely clear.
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Article Synopsis
  • The article with DOI: 10.1039/C9RA10747A has been officially retracted.
  • This means the findings or conclusions in the article are no longer considered valid.
  • Retraction typically occurs due to issues like errors, misconduct, or concerns about the research methodology.
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Study on Translational toxicology of Senna obtusifolia aqueous extract.

Toxicon

November 2024

The Second Hospital, Shandong University, Jinan, 250033, China; Advanced Medical Research Institute, Shandong University, Jinan, 250012, China. Electronic address:

Article Synopsis
  • Recent reports highlight increasing clinical adverse drug reactions (ADRs) associated with Senna obtusifolia, particularly its hepatotoxic effects.
  • In a study, repeated administration of Senna obtusifolia Aqueous Extract (SE) confirmed the liver as the primary target organ for toxicity, with additional in vitro verification of hepatotoxicity.
  • The study's findings suggest that SE-induced liver damage may be linked to inflammation, as indicated by elevated levels of pro-inflammatory cytokines and specific gene and protein expressions in rat livers and liver cancer cells.
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Metabolic and Immunological Implications of MMECAF-Mediated Hypoxia Signaling in Pancreatic Cancer Progression: Therapeutic Insights and Translational Opportunities.

Biol Proced Online

September 2024

Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Department of Integrative Oncology, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China.

Article Synopsis
  • * This research identified a specific fibroblast subpopulation, MMECAFs, expressing the Membrane Metalloendopeptidase, using single-cell transcriptome sequencing and various screening methods related to tumor characteristics.
  • * Findings suggest that MMECAFs play critical roles in promoting cancer through hypoxia-related signaling and inflammatory pathways, and their high expression correlates with worse patient survival rates, indicating potential targets for therapy.
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Decoding semantic concepts for imagination and perception tasks (SCIP) is important for rehabilitation medicine as well as cognitive neuroscience. Electroencephalogram (EEG) is commonly used in the relevant fields, because it is a low-cost noninvasive technique with high temporal resolution. However, as EEG signals contain a high noise level resulting in a low signal-to-noise ratio, it makes decoding EEG-based semantic concepts for imagination and perception tasks (SCIP-EEG) challenging.

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