5 results match your criteria: "Tianjin' s Clinical Research Center for Cancer[Affiliation]"
Mini and enhanced CRISPR activators for cancer therapies.
J Adv Res
November 2024
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Article Synopsis
- - The study explores the use of Cas9 as a programmable transcription activator, aiming to improve its efficiency for potential applications in cancer therapy by enhancing CRISPR activation tools.
- - Researchers fused transcriptional coactivators with the dCas9-VPR system to create a new tool, dCas9-NVPR, which showed increased effectiveness in activating tumor suppressor genes in cancer cells.
- - The findings suggest that this advanced CRISPRa system could be a promising approach for developing genetic therapies targeting cancer by restoring the function of key tumor suppressor genes.
Supramolecular nanodrug targeting CDK4/6 overcomes BAG1 mediated cisplatin resistance in oral squamous cell carcinoma.
J Control Release
April 2024
Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:
Chemoresistance to cisplatin remains a significant challenge affecting the prognosis of advanced oral squamous cell carcinoma (OSCC). However, the specific biomarkers and underlying mechanisms responsible for cisplatin resistance remain elusive. Through comprehensive bioinformatic analyses, we identified a potential biomarker, BCL2 associated athanogene-1 (BAG1), showing elevated expression in head and neck squamous cell carcinoma (HNSCC).
View Article and Find Full Text PDFTargeting IL-6/STAT3 signaling abrogates EGFR-TKI resistance through inhibiting Beclin-1 dependent autophagy in HNSCC.
Cancer Lett
April 2024
Department of Maxillofacial and Otorhinolaryngological Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, 300060, China; National Clinical Research Center for Cancer, Tianjin, 300060, China; Tianjin' s Clinical Research Center for Cancer, Tianjin, 300060, China; Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China; Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin, 300060, China; National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin, 300060, China. Electronic address:
Head and neck squamous cell carcinoma (HNSCC) is featured by notorious EGFR tyrosine kinase inhibitor (TKI) resistance attributable to activation of parallel pathways. The numerous phase I/II trials have rarely shown encouraging clinical outcomes of EGFR-TKIs during treatment in HNSCC patients with advanced tumors. A unique IL-6/STAT3 signaling axis is reported to regulate multiple cancer-related pathways, but whether this signaling is correlated with reduced EGFR-TKI responsiveness is unclear.
View Article and Find Full Text PDFMutational landscape of pan-cancer patients with PIK3CA alterations in Chinese population.
BMC Med Genomics
July 2022
National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, West Huan-Hu Road, Ti Yuan Bei, Hexi District, Tianjin, 300060, China.
Purpose: To analyze the mutational landscape of pan-cancer patients with PIK3CA mutations in Chinese population in real-world.
Methods: We analyzed PIK3CA mutation status in sequencing data of cell-free DNA from plasma and genomic DNA from matched peripheral blood lymphocyte in 11,904 Chinese pan-cancer patients, and compared them with genomic data from the Catalogue of Somatic Mutations in Cancer (COSMIC) database. Besides, concomitant genomic aberrations in PIK3CA-mutated samples were detected to investigate cancer driver genes, as well as their enriched pathways.
THE INFLUENCE OF LOW-DOSE OCCUPATIONAL RADIATION EXPOSURE ON PERIPHERAL BLOOD CELLS IN A COHORT OF CHINESE MEDICAL RADIATION WORKERS.
Radiat Prot Dosimetry
March 2022
Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin' s Clinical Research Center for Cancer, Tianjin, China.
Objectives: The study aims to assess the change of peripheral blood cell numbers following protracted low-dose radiation exposure among medical radiation workers.
Methods: A cohort of 375 Chinese medical workers were followed for 5 years (2015-19) and recorded the changes in blood cells and cumulative doses. T-test, least significant difference-T test, variance analysis and correlation analysis were utilized in this study.