37,267 results match your criteria: "Thrombolytic Therapy"

Article Synopsis
  • Extracorporeal membrane oxygenation (ECMO) may be necessary for some patients with severe pulmonary embolism (PE), but its clinical outcomes are not well understood.
  • *In a study analyzing data from 2035 patients with acute PE, 76 required ECMO, with findings indicating high rates of cardiac arrest (88.2%) at diagnosis and a 30-day death rate of 30.3%, all related to PE.
  • *The research highlighted significant complication rates, including a 54% incidence of major bleeding, suggesting the need for improved management strategies and future clinical trials.
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This study investigates the effects of rt-PA thrombolytic therapy at varying times on neurological function and complications in acute cerebral infarction (ACI) patients. A total of 120 ACI patients admitted between August 2019 and July 2021 were divided into three groups based on the timing of rt-PA treatment: <3h (40 patients), 3-4.5h (55 patients), and >4.

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Background: This study seeks to investigate the contemporary use and effectiveness of fibrinolysis as a first-line option in pediatric empyema.

Methods: The Pediatric Health Information System (PHIS) was queried to identify patients with empyema without fistula (2018-2023). First-line treatments were chest drainage (CD), chest drainage with fibrinolysis (CDF), and video-assisted thoracoscopic surgery/open decortication (VATS/OD).

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Trends in Transcatheter Mechanical Thrombectomy for Management of Acute Pulmonary Embolism.

Circ Cardiovasc Qual Outcomes

November 2024

Division of Cardiovascular Disease, Lifespan Cardiovascular Institute, Warren Alpert Medical School of Brown University, Providence, RI (A.E., O.H., M.S., S.T.M., P.A.S., J.D.A.).

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Article Synopsis
  • Cerebral venous thrombosis (CVT) is a rare type of stroke that may be linked to COVID-19 infection and vaccinations, with the management evolving to include fibrinolysis and mechanical thrombectomy.
  • A literature review highlighted that low-molecular-weight heparin (LMWH) and unfractionated heparin (UH) are the recommended first-line treatments for acute CVT, while warfarin can be used later for prevention, although DOACs show promise as alternatives.
  • Treatment approaches for COVID-19 related CVT are similar to non-COVID-19 CVT, but vaccine-related CVT requires different strategies involving non-heparin anticoagulants and possibly immunotherapy or steroids, emphasizing the
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Electroacupuncture extends the time window of thrombolytic therapy in rats by reducing disruptions of blood-brain barrier and inhibiting GSDMD-mediated pyroptosis.

Brain Res

December 2024

College of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing 210023, China; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Objective: Thrombolytic therapy is the primary treatment for acute ischemic stroke. Extending the therapeutic time window can effectively reduce the harmful side effects associated with thrombolytic therapy. Although electroacupuncture (EA) has been shown to extend this time window, the specific mechanisms remain unclear.

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Risk of angioedema and thrombolytic therapy among stroke patients: An analysis of data from the FDA Adverse Event Reporting System database.

Neurotherapeutics

October 2024

Department of Neurology and Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, 610041, China; Sichuan Center of Technology Innovation for Real World Data, Chengdu, 610041, China. Electronic address:

The angioedema risk may vary among stroke patients receiving different thrombolytic agents. This study aimed to investigate the angioedema risk associated with different thrombolytic agents and to identify associated risk factors. We conducted a large-scale retrospective pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS) database.

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Acute Reperfusion Therapies and Prognosis in Nonagenarian Stroke Patients.

Gerontology

December 2024

Department of Neurology, Bicêtre Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris Saclay University, Le Kremlin Bicêtre, France,

Article Synopsis
  • Thrombolysis and endovascular thrombectomy (EVT) are standard stroke treatments, and this study investigates their effectiveness specifically in nonagenarians (patients aged 90 and older), hypothesizing that their prognosis may be worse than that of younger patients.
  • The study analyzed outcomes of 96 nonagenarians treated with these therapies, finding that they had more pre-existing health conditions and lower independence before the stroke compared to patients aged 80-89.
  • Results indicated that while treatment timelines and successful reperfusion rates were similar, nonagenarians had significantly poorer functional recovery at 3 months (14.3% vs. 34.0%) and a much higher mortality rate (60.2% compared to 16
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Objectives: To explore a novel model of mobile stroke units (MSUs) integrated with rural emergency medical stations for pre-hospital care of stroke patients in remote areas.

Methods: We used MSUs + Ambulance mode, where both the MSUs and conventional ambulances are sent to the patient's location. The conventional ambulance coordinates with the MSUs to choose the fastest route to meet and transfer the patient at the point along the way.

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Role of Hypoperfusion Intensity Ratio in Vessel Occlusions: A Review on Safety and Clinical Outcomes.

AJNR Am J Neuroradiol

October 2024

From the Department of Radiology and Radiological Sciences (S.R., D.A.L., H.A.S., R.X., A.E.H., V.C.U., R.H.L., E.B.M., H.L., V.S.Y.), Johns Hopkins University, Baltimore, Maryland, U.S.; Department of Medicine (A.N.), Allama Iqbal Medical College, Lahore, Punjab, Pakistan; Mass General Brigham (A.B.U.K.), Massachusetts, U.S.; Division of Interventional Radiology, Department of Radiology (A.H.), Northwestern Memorial Hospital, Chicago, Illinois, U.S.; Dow University of Health Sciences (S.W.), Karachi, Pakistan; HMH JFK University Medical Center (S.K.), Edison, New Jersey, U.S.; University of Toledo (S.M.O.), Toledo, Ohio, U.S.; Shadan Institute of Medical Sciences (N.B.), Hyderabad, Telangana, India; Stony Brook University Renaissance School of Medicine (V.S.V), New York, U.S.; University of Cincinnati College of Medicine (Y.N.A.), Cincinnati, Ohio, U.S.; Department of Neurology (R.L.), Johns Hopkins Medicine, Baltimore, Maryland, U.S.; Neuroendovascular Program (A.A.D.), Massachusetts General Hospital, Boston, Massachusetts, U.S.; Department of Diagnostic and Interventional Neuroradiology (A.G.), Erasme University Hospital, Brussels, Belgium; Department of Neurology (G.W.A., J.J.H.), Stanford University, Stanford, California, U.S.; Department of Radiology (T.D.F.), Neuroendovascular Program, University Medical Center Münster, Munster, Germany.

The hypoperfusion intensity ratio (HIR) is a quantitative metric used in vascular occlusion imaging to evaluate the extent of brain tissue at risk due to hypoperfusion. Defined as the ratio of tissue volume with a time-to-maximum (Tmax) of >10 seconds to that of >6 seconds, HIR assists in differentiating between the salvageable penumbra and the irreversibly injured core infarct. This review explores the role of HIR in assessing clinical outcomes and guiding treatment strategies, including mechanical thrombectomy and thrombolytic therapy, for patients with large vessel occlusions (LVOs).

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In-hospital outcomes of intravenous recombinant tissue plasminogen activator treatment for acute ischemic stroke in patients aged >80 years: Findings from the Chinese Stroke Center Alliance.

J Stroke Cerebrovasc Dis

January 2025

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; National Center for Healthcare Quality Management in Neurological Diseases, Beijing, China; Center for Stroke, Beijing Institute for Brain Disorders, Beijing, China. Electronic address:

Article Synopsis
  • This study focused on the effects of intravenous recombinant plasminogen activator (IV rt-PA) on Chinese patients over age 80 who experienced acute ischemic stroke (AIS), comparing their outcomes to younger patients aged 18-80.
  • Researchers analyzed data from a nationwide platform, noting primary outcomes like all-cause mortality and secondary outcomes such as rates of intracranial hemorrhage and changes in stroke severity.
  • Results showed higher mortality rates (2.6% for >80 years vs. 0.8% for 18-80 years) and intracranial hemorrhage (6.7% vs. 3.1%) in older patients, indicating that while IV rt-PA is beneficial, it poses
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Accelerating thrombolysis of arterial thrombus with NO-MBs UTMD therapy.

Eur J Pharm Biopharm

December 2024

Department of Ultrasonography, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, China; The Department of Medical Ultrasound, First Affiliated Hospital of Shenzhen University, Second People's Hospital of Shenzhen, Guangdong Province, China. Electronic address:

Article Synopsis
  • Arterial thrombotic disease is a significant health issue, and nitric oxide (NO) can help delay thrombosis and tissue damage, but its systemic delivery poses challenges.
  • A novel approach using lipid microbubbles filled with NO (NO-MBs) and ultrasound-targeted microbubble destruction (UTMD) allows for targeted, real-time delivery of NO and has shown promising results in accelerating thrombolysis.
  • The treatment demonstrated strong biosafety and effectively reduced inflammation and oxidative stress associated with thromboembolism, indicating its potential for treating arterial thrombotic diseases.
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Minor strokes, which account for about 50 % of all ischemic strokes are not necessarily benign and carry a substantial risk of long-term disability. Due to persisting uncertainties regarding optimal recanalization strategies mild strokes may represent a therapeutical challenge for clinicians. The aim of this review is to provide an overview of the current state of knowledge and questions remaining to be answered.

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Rationale: Stroke is a relatively frequent complication occurring in patients with systemic lupus erythematosus (SLE). The increasing number of patients with Ischemic Stroke secondary to SLE aroused the clinician's concern. SLE thrombosis markers, diagnostic high-resolution magnetic resonance image (HR-MRI), and therapeutic interventions for acute ischemic stroke were recently coming into focus perspectives from the field.

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Objective: About 25% of patients with acute ischemic stroke (AIS) present within the intravenous thrombolytic (IVT) therapeutic window of <4.5 h. This study is to elucidate the safety and efficacy of IVT in the extended therapeutic window (ETW) in patients with AIS.

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Serum lncRNA RAMP2-AS1 Served as a Biomarker of Deep Vein Thrombosis Occurrence and Development in Elderly.

Indian J Hematol Blood Transfus

October 2024

Department of Blood Transfusion, Jinan Central Hospital, No.105 Jiefang Road, Jinan, 250013 China.

The incidence of deep vein thrombosis (DVT) is increasing with aging, which needs a screening and monitoring biomarker. This study focused on the significance of aging- and angiogenesis-related lncRNA RAMP2-AS1 (RAMP2-AS1) aiming to identify a promising biomarker for the incidence of DVT. Serum samples were collected from 63 healthy individuals and 98 patients with DVT.

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Article Synopsis
  • Clinical trials indicate that using a mobile stroke unit (MSU) for prehospital management can lead to better outcomes for acute ischemic stroke patients who may need thrombolysis, but real-world data is limited.
  • This study aimed to compare the effects of prehospital MSU management versus standard emergency services (EMS) on patient disability levels at the time of hospital discharge.
  • The analysis included over 19,000 patients treated across multiple hospitals, revealing that those managed in an MSU had improved functional outcomes compared to those receiving standard EMS care.*
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Neutrophil-Mimetic Upconversion Photosynthetic Nanosystem Derived from Microalgae for Targeted Treatment of Thromboembolic Stroke.

ACS Nano

November 2024

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, SAR 999078, China.

Article Synopsis
  • Thromboembolic strokes are the most common type and pose significant health and societal challenges despite existing treatments like intravenous thrombolysis, which have limitations due to their narrow therapeutic window and inflammatory side effects.
  • This study presents a new microalgae-derived nanosystem designed to target thromboembolic strokes more effectively, leveraging a neutrophil-mimetic approach that enhances specificity and accumulation at the thrombus site.
  • The nanosystem offers multiple therapeutic benefits, including controlled release of a thrombolytic agent and the ability to boost ATP and NADPH levels, which can mitigate inflammation, oxidative stress, and neuronal injury during stroke recovery.
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Background: There is a lack of health economics studies on the treatment of acute lower extremity deep venous thrombosis to measure the benefits to patients. The purpose of this study was to evaluate the cost-effectiveness of anticoagulation (AC), percutaneous mechanical thrombectomy (PMT), and catheter-directed thrombolysis (CDT).

Methods: The above 3 methods were selected according to the patient's treatment wishes.

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Spontaneous spinal epidural hematoma (SSEH) is a rare cause of neck pain and hemiparesis. Clinicians should keep SSEH in mind as a rare stroke mimic presenting with hemiparesis to avoid needless and potentially hazardous thrombolytic therapy. Taking a careful history is useful for making a correct diagnosis.

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Catheter-directed thrombolysis reduces the thrombolytic time and dose of thrombolytic drugs without affecting the thrombolytic effect to ensure that bleeding does not occur. This helps clinicians choose safer CDT treatments for their patients. We combine the historical process of catheter-directed thrombolytic therapy for VTE and prospect the future development of CDT.

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Venous thromboembolism (VTE) is a serious health condition and represents an important cause of morbidity and, in some cases, mortality due to the lack of effective treatment options. According to the Centers for Disease Control and Prevention, 3 out of 10 people with VTE will have recurrence of a clotting event within ten years, presenting a significant unmet medical need. For some VTE patients, symptoms can last longer and have a higher than average risk of serious complications; in contrast, others may experience complications arising from insufficient therapies.

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Delivering urokinase-type plasminogen activator using mulberry leaf exosomes enables thrombolysis and remodeling of venous microenvironments.

Int J Biol Macromol

December 2024

State Key Laboratory of Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China; Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile, Chongqing 400715, China. Electronic address:

In the treatment of thrombosis, conventional nanocarriers inevitably have problems, such as adverse reactions and difficulties in synthesis. Inspired by the concept of 'medicine food homology,' we extracted and purified natural exosomes from mulberry leaves as carriers for the delivery of urokinase-type plasminogen activator (uPA) for targeted therapy. The obtained mulberry leaf exosomes (MLE) possessed a desirable hydrodynamic particle size (119.

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Background: Non-immunogenic staphylokinase is a modified recombinant staphylokinase with low immunogenicity, high thrombolytic activity, and fibrin selectivity.

Objectives: To assess the safety and efficacy of a single intravenous bolus of non-immunogenic staphylokinase compared with those of alteplase in patients with massive pulmonary embolism and hemodynamic instability.

Methods: A randomized, open-label, multicenter, parallel-group, non-inferiority trial, the FORPE (FORtelyzin Pulmionary Embolism), was conducted in Russia.

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Insoluble proteomics analysis of acute intracranial large vessel occlusive thrombus.

J Thromb Haemost

October 2024

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; NHC Key Laboratory of Prevention and Treatment of Cerebrovascular Diseases, Zhengzhou, Henan, China. Electronic address:

Article Synopsis
  • Acute large vessel occlusion (LVO) stroke is common and serious, with many patients facing complications despite treatment, highlighting the need to understand thrombus formation.
  • The study analyzed insoluble proteins from thrombi in patients with different stroke types (cardiogenic embolic vs. large artery atherosclerotic) using advanced mass spectrometry techniques to explore their characteristics and identify potential biomarkers.
  • Results revealed a detailed protein atlas, showing significant differences in inflammatory and extracellular matrix pathways between thrombus sources, and identified two biomarkers (IDH2 and HSPG2) that may help diagnose these conditions effectively.
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