887 results match your criteria: "Thrombocytosis Secondary"
Diagnosis and Treatment of Polycythemia Vera: A Review.
JAMA
November 2024
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Article Synopsis
- - Polycythemia vera (PV) is a rare blood disorder affecting around 65,000 Americans, characterized by an increased mass of red blood cells, leading to a higher risk of blood clots, with symptoms such as itching and enlarged spleen.
- - Diagnosis often involves identifying elevated hemoglobin levels and the presence of a specific JAK2 gene variant, with many patients also experiencing increased platelet and white blood cell counts; survival rates range from 14 to 28 years following diagnosis.
- - Treatment typically includes therapeutic phlebotomy and low-dose aspirin for thrombosis prevention, with higher-risk patients possibly receiving additional therapies like hydroxyurea or Ruxolitinib for symptom relief; a small percentage may
Background/aim: Ovarian cancer remains a major cause of death in women worldwide, mainly due to late diagnosis and the lack of a reliable screening test for early detection of the disease. In this context, attention has been focused on the identification of other prognostic factors that might allow a better identification of cases with worse long-term outcome.
Patients And Methods: Data of patients who underwent cytoreductive surgery between 2014-2019 were retrospectively reviewed and 57 patients were considered eligible for this study.
Newly diagnosed essential thrombocythemia leading to cardiogenic shock: a case report.
BMC Cardiovasc Disord
October 2024
Department of Internal Medicine, Methodist Dallas Medical Center, 1441 N Beckley Ave, Dallas, TX, 75203, USA.
Article Synopsis
Polycythemia Vera With High Serum Erythropoietin Level: A Case Report and Literature Review.
Cureus
September 2024
Internal Medicine Department, Hamad Medical Corporation, Doha, QAT.
Article Synopsis
- - Polycythemia vera (PV) is a serious blood condition characterized by an increase in red blood cells (erythrocytosis) and symptoms like headaches and weakness, often requiring the exclusion of other causes before diagnosis.
- - A case of a 47-year-old woman highlights the diagnostic process for PV, which included high hemoglobin levels and a positive JAK-2 mutation test, ultimately leading to the diagnosis despite elevated erythropoietin (EPO) levels.
- - Treatment for PV primarily involves phlebotomy to lower high blood counts, with additional options like low-dose aspirin for high-risk patients and anticoagulation for those experiencing blood clots.
Real-World Impact of Deep Targeted Sequencing on Erythrocytosis and Thrombocytosis Diagnosis: A Reference Centre Experience.
Cancers (Basel)
September 2024
Centro Nacional de Investigaciones Oncológicas, Complutense University, 28029 Madrid, Spain.
Article Synopsis
- Many cases of erythrocytosis and thrombocytosis are still classified as "idiopathic" due to factors like lack of secondary causes or inconclusive tests, despite advancements in genetic testing.
- Next-generation sequencing (NGS) was reviewed in 175 patients, leading to diagnoses in a small number: 5.1% for polycythaemia vera and 6.8% for familial erythrocytosis, with low EPO levels and family history being predictors.
- The study found a higher success rate in diagnosing thrombocytosis cases, with 25.9% identified as having essential thrombocythemia, but overall, the low variant detection rate suggests the need for comprehensive initial screening before using N
Article Synopsis
- Mutations in a protein called calreticulin (mutCALR) cause blood disorders known as myeloproliferative neoplasms (MPNs), but there aren’t any treatments specifically targeting this mutation.
- A new antibody called INCA033989 can specifically attack cells with the mutCALR mutation, stopping them from growing and causing problems.
- In tests on mice, INCA033989 not only prevented issues like high blood cell counts but also showed it could help treat the disease without harming normal blood cell production.
Indicators for Osteomyelitis in Children With Sickle Cell Disease Admitted With Vaso-Occlusive Crises.
Cureus
August 2024
Hematology and Oncology, Prince Sultan Oncology Center, King Salman Armed Forces Hospital, Tabuk, SAU.
Article Synopsis
- - Sickle cell disease (SCD) is a genetic disorder where individuals have a mutated form of hemoglobin, leading to a range of complications like osteomyelitis, particularly affecting bones like the tibia and femur.
- - This study aimed to identify the signs that help diagnose osteomyelitis in pediatric patients with SCD who were experiencing vaso-occlusive crises or suspected osteomyelitis.
- - Involving 28 children, the study found that most blood cultures showed no growth, but some did have infections like salmonella. Key indicators such as leukocytosis and high ferritin levels were linked to osteomyelitis, with diagnostic imaging revealing certain cases of bone edema.
Etiology and clinical course of severe and extreme thrombocytosis in children: a retrospective single-center study.
Eur J Pediatr
November 2024
Department of Hematology & Oncology, Kobe Children's Hospital, Minatojima-Minamimachi 1-6-7, Chuo-Ku, Kobe, 650-0047, Japan.
Article Synopsis
- This study focused on children aged 0-18 years with severe (ST) and extreme thrombocytosis (ET), analyzing over 120 patients with platelet counts exceeding 900,000/µL to understand their causes and clinical outcomes.
- The most common underlying conditions were congenital heart disease and Kawasaki disease, with only a small percentage showing primary thrombocytosis and a low incidence of thrombosis.
- It was found that lower hemoglobin levels at the onset of thrombocytosis were linked to the development of ET, indicating potential differences in how thrombocytosis manifests in children compared to adults.
Transformation into acute myeloid leukemia with t(8;21)(q22;q22.1); RUNX1::RUNX1T1 from JAK2-mutated essential thrombocythemia: a case report.
J Med Case Rep
August 2024
Department of Hematology, Saitama Medical University Hospital, 38 Morohongo, Iruma-gun, Moroyama, Saitama, 350-0495, Japan.
Article Synopsis
- A 74-year-old woman in Japan had a blood disorder called essential thrombocythemia (ET), which made her blood platelets too high.
- After two years, she developed a more serious condition called secondary acute myeloid leukemia (AML) with specific chromosome changes (t(8;21)).
- She received treatment with special medicines and after the first round, her harmful blood cells started to disappear.
The History of Macrophage Activation Syndrome in Autoimmune Diseases.
Adv Exp Med Biol
August 2024
Hospital for Sick Children (SickKids), University of Toronto, Toronto, ON, Canada.
Article Synopsis
- In 1979, hemophagocytic lymphohistiocytosis (HLH) was recognized as a non-cancer disease related to certain immune cells called histiocytes.
- There are two main types of HLH: familial (which runs in families) and secondary (which happens because of other diseases like autoimmune disorders).
- Macrophage activation syndrome (MAS) is a type of secondary HLH that occurs with autoimmune diseases and has unique signs and treatments, especially in cases like systemic juvenile idiopathic arthritis (sJIA).
Managing Multifactorial Deep Vein Thrombosis in an Adolescent: A Complex Case Report.
J Crit Care Med (Targu Mures)
July 2024
George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania.
Article Synopsis
- - The rising incidence of deep vein thrombosis (DVT) in pediatric patients is linked to various new risk factors and lifestyle changes, despite being rarely diagnosed in this population.
- - A case of a 17-year-old female who developed extensive DVT post-surgery for a benign splenic cyst highlights the complexity of the condition in teens with multiple risk factors, including obesity and a central venous catheter.
- - Managing DVT in pediatric patients requires a tailored approach and interdisciplinary care due to its potential severity and resistance to standard treatment methods.
The assessment of health-related quality of life in patients with polycythemia vera.
Medicine (Baltimore)
July 2024
Department of Hematology, Ege University Faculty of Medicine, İzmir, Türkiye.
Article Synopsis
Hydroxyurea achieved a hematologic response in a patient with β-thalassemia and secondary severe thrombocytosis post splenectomy.
Pediatr Blood Cancer
October 2024
Department of Hematology, Zigong First People's Hospital, Zigong, China.
Initiating-clone analysis in patients with acute myeloid leukemia secondary to essential thrombocythemia.
Sci Rep
July 2024
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Tsurumai-Cho 65, Showa-Ku, Nagoya, 466-8550, Japan.
Article Synopsis
- Most patients with essential thrombocythemia (ET) have mutations in JAK2, CALR, or MPL genes, which can lead to additional mutations when transforming into acute myeloid leukemia (AML).
- In a study of paired samples from eight patients, researchers found that some JAK2-unmutated clones proliferated at AML transformation, even when JAK2-mutated clones were dominant in ET.
- The findings suggest the existence of common initial clones in ET that can lead to transformed AML, highlighting the importance of further research on specific mutations like SMARCC2, UBR4, and ZNF143.
Long-term pharmacodynamic and clinical effects of twice- versus once-daily low-dose aspirin in essential thrombocythemia: The ARES trial.
Am J Hematol
August 2024
Department of Safety and Bioethics, Section of Pharmacology, Catholic University School of Medicine, Rome, Italy.
Article Synopsis
- People with essential thrombocythemia (ET) usually take low-dose aspirin once a day to avoid blood clots, but this isn't always effective because their platelet levels change quickly.
- A study tested if taking aspirin twice a day would work better and found that it did help lower certain blood markers and symptoms over 20 months.
- The results showed that twice-daily aspirin caused fewer major blood clots, didn't lead to significant bleeding problems, and made patients feel better overall compared to taking it once a day.
Article Synopsis
- Polycythemia is common and often related to secondary conditions like high-altitude hypoxia, while a rare condition called polycythemia vera (PV) requires a specialized treatment approach.
- In a study analyzing lab records over three years, out of 208 JAK2 tests, 136 were specifically for polycythemia evaluation, with 22 (16.7%) testing positive for the PV mutation.
- The findings suggest that many patients at high altitude might be incorrectly evaluated for PV based solely on hemoglobin/hematocrit levels; a distinct CBC pattern in PV patients could help streamline evaluations and reduce unnecessary tests.
Peritoneal dialysis-associated peritonitis, caused by superior mesenteric artery thrombosis with intestinal necrosis: a case report.
CEN Case Rep
June 2024
Department of Nephrology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Article Synopsis
- Peritoneal dialysis (PD) can lead to a common complication called enteric peritonitis, which is often overlooked, especially in cases where cultures come back negative, increasing the risk of mortality.
- A 67-year-old man who had been on PD for 3 years was admitted to the hospital with PD-associated peritonitis after suffering from a gastric ulcer and severe anemia; tests showed high white blood cell counts but negative cultures.
- Eventually diagnosed with superior mesenteric artery thrombosis and intestinal necrosis, he underwent emergency surgery and treatment, leading to recovery and hospital discharge after 47 days.
Reactive Thrombocytosis: A Bizarre Consequence of Splenectomy.
Cureus
April 2024
Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Wardha, IND.
Article Synopsis
- Platelets are tiny parts of our blood that help stop bleeding by forming clots.
- Thrombocytosis is when the body makes too many platelets, often because of things like infections or surgeries.
- A woman, 35 years old, had a surgery to help her with a liver condition and then felt weak and had tingling in her hands for eight days after.
Patient's self-reported quality of life as a prognostic factor in metastatic renal cell carcinoma initially treated with TKI: nomogram proposal.
World J Urol
April 2024
Urology and Nephrology Department, Oncologic Urology Unit, University Hospital Virgen del Rocío, Av. Manuel Siurot, S/n, 41013, Seville, Spain.
Article Synopsis
- There are many factors that help doctors understand how well patients with metastatic renal cell carcinoma (mRCC) might do, but some tools to help are not very perfect.
- A study looked at 78 patients to see how patient feelings and experiences might predict their survival better than just a doctor’s opinion.
- The results showed that a specific questionnaire (FKSI 19 score) could help tell how well patients may do, and it might work better than traditional methods used by doctors.
A case report and literature review of IgA nephropathy presenting as nephrotic syndrome in polycythemia vera.
CEN Case Rep
December 2024
Department of General Medicine, SRM Medical College Hospital and Research Centre, Kattankulathur, Tamil Nadu, 603203, India.
Article Synopsis
- A 66-year-old man who doesn't smoke noticed swelling in his legs and blood in his urine for 2 weeks.
- Doctors found he had high blood pressure, high red blood cells, and a kidney problem.
- After tests, they discovered he had a rare blood disease and kidney damage, so they started treating him with special medications.
Real-world status of treatment for lymphoid neoplasms developed during the course of myeloproliferative neoplasms in Japan.
Hematology
December 2024
Department of Advanced Hematology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Article Synopsis
- This study looked at patients in Japan who have myeloproliferative neoplasms (MPNs) and also developed lymphoid cancers.
- Researchers wanted to see how these patients were treated for their lymphoid cancers, like lymphoma, while also managing their MPNs.
- The results showed that most patients could still receive strong treatments for their lymphoid cancers, especially for a type called diffuse large B-cell lymphoma, without making their MPN treatment worse.
Splenic torsion mistaken for an ovarian cyst: a case report.
J Med Case Rep
April 2024
Department of Surgery, Aga Khan University, Karachi, Pakistan.
Article Synopsis
- Wandering spleen is when the spleen moves from its normal spot in the body, usually going lower into the abdomen or pelvis, and it can be hard to diagnose without proper imaging like CT scans.
- A 22-year-old woman went to the emergency room with severe stomach pain, and while an ultrasound suggested an ovarian cyst, further tests showed she had a wandering spleen that had twisted and was not getting enough blood.
- After surgery to remove the spleen, she recovered well and was discharged, highlighting how important quick diagnosis and treatment are for this condition.
Non-metastatic Nephrogenic Hepatic Dysfunction (Stauffer Syndrome) and Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) in a Patient With Renal Cell Carcinoma Coinciding With Liposarcoma.
Cureus
March 2024
Nephrology, Veterans Affairs Medical Center, Mountain Home, Johnson City, USA.
Article Synopsis
- Stauffer syndrome is a health condition that affects the liver and is linked to certain types of tumors, especially those in the kidneys.
- It shows signs like yellow skin (jaundice), high liver enzymes, and sometimes a swollen liver or spleen, but not because of a blockage.
- This syndrome can happen with other cancers too, and in one case, a 76-year-old patient had problems with both their liver and a tumor in their kidneys.
Iron deficiency-induced thrombocytosis presenting with blue toe syndrome.
Clin Case Rep
April 2024
Department of Cardiology Hamad Medical Corporation Doha Qatar.
Article Synopsis
- Blue toe syndrome is a condition where the toes turn blue, and it can be caused by different factors.
- A 38-year-old man from Saudi Arabia had blue toe syndrome and doctors found out he had very high platelet levels because of not having enough iron in his body.
- He received treatment with pain relief, blood-thinning medicines, fluids, and iron, and got better after a few days.