Lemierre's Syndrome: A Case Report.

A 21-year-old woman presented with a sore throat and systemic symptoms, including fever, diarrhea, and chest pain, progressing to sepsis. Imaging revealed a pharyngeal abscess, thrombophlebitis of the left internal jugular vein, and septic emboli. Blood cultures confirmed Fusobacterium necrophorum, and the patient was diagnosed with Lemierre's syndrome.

First Report of Hand, Foot, and Mouth Disease (HFMD) Outbreak in the West Bank, Palestine: Molecular Characterization of Coxsackievirus A16 (CV-A16).

Hand, foot, and mouth disease (HFMD) is a mild self-limited childhood infectious disease caused by a variety of enteroviruses (EVs). To investigate the molecular epidemiology of EVs associated with HFMD and their clinical presentation during the HFMD outbreak that occurred in the Jenin district, Palestine, from May to August 2024. Forty-four (44) throat and vesicular swabs were tested for enteroviral infections using two RT-PCR assays targeting both the 5'NTR and the VP1-2A regions of the enteroviral genome for the diagnosis and genotyping.

Rescue Tracheal Reconstruction via Platysma Myocutaneous Flap Following Necrosis of Sternocleidomastoid Muscle Myoperiosteal Flap.

A case of a 60-year-old male patient with thyroid cancer invading the trachea was presented in the current study. After the initial surgery via a sternocleidomastoid muscle (SCM) clavicular periosteal flap for tracheal reconstruction, the patient experienced flap necrosis. Subsequent debridement and tracheocutaneostomy were performed, followed by a successful repair of the tracheal defect using a platysma myocutaneous flap.

Antibiotic Use Can be De-escalated During Transoral Endoscopic Thyroidectomy: A Bacterial Culture-Based Study.

To explore the possibility of reducing the use of antibiotics after transoral endoscopic thyroidectomy vestibular approach (TOETVA). A retrospective study was conducted on patients with thyroid tumors who were diagnosed and underwent surgical treatment at our hospital from 2022 to 2024. Patients diagnosed with T1-stage differentiated thyroid cancer or a benign retrosternal goiter <4 cm with cosmetic needs were included in the current study.

Relationship of influenza virus to inflammatory factors and immune function in elderly patients with COPD: A retrospective analysis.

Objective: The aim of this retrospective study was to investigate the relevance of influenza A virus (IAV) in acutely exacerbating airway inflammatory response and disrupting immune function in elderly COPD patients.

Methods: The group conducted a pre-test: using multiplex combined real-time PCR detection kits Multiple real⁃time PCR was used to detect twenty-four pathogens, 385 patients clinically diagnosed with COPD were tested for viral nucleic acid in throat swabs. At the same time, peripheral blood leukapheresis was collected from both groups of patients, and their IL-6, IL-8, IL-1β, and TNF-α levels were detected, along with the levels of T-cell differentiation markers CD4 and CD8, to assess the influence of influenza virus on the immune function of elderly COPD patients and its relevance to the acute exacerbation of airway inflammatory response in elderly COPD patients.

WAYS TO IMPROVE THE RESULTS OF SURGICAL TREATMENT OF DIFFUSE TOXIC GOITER.

Introduction: This article discusses the prevention of intraoperative complications in the surgical treatment of diffuse toxic goiter. The above complications push surgeons to find a more optimal method of surgical treatment.

Aim: Development of new methods to reduce the risk of intraoperative complications in the surgical treatment of patients with diffuse toxic goiter.

Feasibility of utilizing the Modified Centor Criteria in adult virtual care.

The Modified Centor criteria (MCC) is a validated clinical decision tool determining the need for testing in suspected . This study aims to understand the use of this tool to guide testing during remote evaluation. Patients with sore throats and no more than 3 days of symptoms were recruited from the emergency department and urgent care at an urban academic centre in 2019-2022.

Proposing Design Evaluation Metrics for Anesthesia Providers' Workspace in Ambulatory Surgical Settings.

This paper describes the development and utilization of two design evaluation metrics aimed to measure design performance for improving circulation and workflow, situational awareness, and visibility for medication-related activities for anesthesia providers' within their workspace in operating rooms. Proactive performance evaluation of the design of critical areas such as operating rooms can help improve the safety of patients and staff workflows. This paper builds on previous work on task-switching behaviors in anesthesia workspaces to develop performance-based design evaluation metrics for anesthesia providers' workspaces based on their tasks performed during the patient preparation, intra-operative, and post-operative phases of the surgery, considering the presence of multiple anesthesia providers.

Enterovirus D68 Subgenotype B3 Circulation in Children with Acute Respiratory Illness in the State of Alagoas, Brazil.

Enterovirus D68 (EV-D68) is a leading cause of acute respiratory disease outbreaks, especially among children. EV-D68 infections can rapidly progress to severe clinical complications and potentially fatal outcomes. In Brazil, no diagnostic or genomic surveillance of this virus is currently performed.

The Emergence of Coxsackievirus A16 Subgenotype B1c: A Key Driver of the Hand, Foot, and Mouth Disease Epidemic in Guangdong, China.

Background: In 2024, mainland China witnessed a significant upsurge in Hand, Foot, and Mouth Disease (HFMD) cases. Coxsackievirus A16 (CVA16) is one of the primary causative agents of HFMD. Long-term monitoring of theCVA16 infection rate and genotype changes is crucial for the prevention and control of HFMD.

Impact of Viral Co-Detection on the Within-Host Viral Diversity of Influenza Patients.

Numerous studies have documented the evidence of virus-virus interactions at the population, host, and cellular levels. However, the impact of these interactions on the within-host diversity of influenza viral populations remains unexplored. Our study identified 13 respiratory viral pathogens from the nasopharyngeal swab samples (NPSs) of influenza-like-illness (ILI) patients during the 2012/13 influenza season using multiplex RT-PCR.

A Systematic Review of Vitamin D Supplementation in Oncology: Chance of Science or Effectiveness?

Background: Vitamin D (VD) supplementation has increased considerably in the last decade, whether for the prevention or treatment of numerous diseases, including bone, cardiovascular, endocrine, neurologic, psychological, respiratory, infectious, or oncological. The primary objective of this scoping review was to examine and synthesize the scientific evidence on the role of VD in all-type cancer patients undergoing adjuvant and neoadjuvant therapy with chemotherapy (CT) or radiotherapy (RT), namely in improving side effects.

Methods: This review was conducted by selecting papers from the CINAHL, Scopus and PubMed databases based on the descriptor terms mesh and title/abstract, taking into consideration the defined inclusion and exclusion criteria, following the PRISMA-ScR (PRISMA extension for scoping reviews) statement.

Quality Assurance of a Hospital-Based Auditory Verbal Intervention for Children with Hearing Loss.

Auditory Verbal Therapy (AVT) has spread globally in the past few years due to its proven positive effect as a rehabilitation method for children with hearing loss (HL). In 2023, a three-year hospital-based AV intervention was implemented in Denmark as a government-funded offer to all children with HL. In the present study, we introduce and study a protocol for facilitating this implementation with a specific focus on clinical applicability and quality assurance.

Perceptions of and Responses to Wildfire Smoke Among New York State Residents: A Cross-Sectional Study.

Exposure to wildfire smoke (WFS) is associated with detrimental physical and mental health. Periods of sustained WFS are predicted to increase with climate change, affecting populations globally. Using a retrospective cross-sectional study, we assessed perceptions of and responses to WFS in a cohort of New York State (NYS) residents in Summer 2023.

A Surgical Hazard During Adenoidectomy in Children-A Case Report.

Adenoidectomy is one of the world's most frequently performed surgical procedures. Although the operation is relatively simple and with a very low percentage of complications, it can sometimes be accompanied by fatal complications. One such scenario arises when an unrecognized aberrant course of the internal carotid artery is present, particularly if the artery is near or in contact with the oropharynx or nasopharynx.

Assessment of the Interdependencies Between High-Speed Videoendoscopy and Simultaneously Recorded Audio Data in Various Glottal Pathologies.

: This study aimed to investigate the relationships between kymographic parameters derived from high-speed videoendoscopy (HSV) and simultaneously recorded acoustic signals. The research provides insights into the vibratory dynamics of various glottal pathologies, assessed across different glottal widths, and their mutual relations with audio data. : The study included 192 participants categorized as normophonic or having functional or organic lesions (benign, premalignant, and malignant).

Synthesis of titania/activated carbon composites for the synergistic adsorption and photocatalysis of lindane in aqueous solutions.

Lindane (LIND) is an organochlorine pesticide, belonging to the persistent organic pollutants (POPs), which are bioaccumulative with detrimental effects on human health and environment. In the present work, activated carbon (AC) produced from coffee waste after activation with sodium hydroxide (NaOH) and pyrolysis at 800 °C (CWAC-NaOH-800) is tested as adsorbent of LIND, and as substrate for the synthesis of hybrid adsorbent/photocatalytic materials of titanium oxide with activated carbon (TiO/AC) via the sol-gel method, aiming at the synergistic adsorption and photocatalysis of LIND. Three different TiO/AC materials were synthesized at mass ratio of TiO to AC equal to 2.

Deep Learning-Enhanced Ultra-high-resolution CT Imaging for Superior Temporal Bone Visualization.

Rationale And Objectives: This study assesses the image quality of temporal bone ultra-high-resolution (UHR) Computed tomography (CT) scans in adults and children using hybrid iterative reconstruction (HIR) and a novel, vendor-specific deep learning-based reconstruction (DLR) algorithm called AiCE Inner Ear.

Material And Methods: In a retrospective, single-center study (February 1-July 30, 2023), UHR-CT scans of 57 temporal bones of 35 patients (5 children, 23 male) with at least one anatomical unremarkable temporal bone were included. There is an adult computed tomography dose index volume (CTDIvol 25.

A nanozyme-catalyzed nasopharyngeal swab sensor for ultra-fast colorimetric detection and highly sensitive Raman spectroscopic qualitative analysis of influenza virus.

Rapid and sensitive detection of pathogenic viruses is essential for controlling pandemics. In this study, the bimetallic metal-organic framework (MOFs) with enhanced peroxidase (POD)-like activity, termed as MIL-101(CoFe), was developed for ultra-fast colorimetric detection and highly sensitive quantitative Raman assay of influenza viruses in nasopharyngeal swab specimens. The synergistic effect between Fe and Co in MIL-101(CoFe) significantly enhanced the POD-like activity, enabling efficient catalysis of the substrate TMB in the presence of HO to produce blue oxidized TMB (ox-TMB), which has a characteristic Raman peak at 1609 cm.

Sore throat or severe threat? The teleconsultation that uncovered neutropenic sepsis.

This case report describes a telemedicine visit by a patient with fever, sore throat, and odynophagia. The patient had recently started taking propylthiouracil (PTU) for Graves disease. She was referred to the ED, where a complete blood cell count revealed agranulocytosis with a neutrophil count of 200 cells/mm3.

Central Nervous System Infection by Free-Living Nematode in a Human Host in Africa.

Background: Human central nervous system infections due to free-living nematodes, although extremely rare, are usually fatal. Immunodeficiency has not been a feature of most of these cases, unlike the situation pertaining to disseminated infection.

Case Report: An elderly immunocompetent man presented with a history of tinnitus and otalgia, progressing to central nervous system involvement with confusion, weakness, and other neurological signs.

Teenagers and Young Adults with Cochlear Implants: A Multidisciplinary Follow-Up Study Approach and Baseline Characteristics.

: Early pediatric cochlear implantation positively impacts early language outcomes. The Teenager and Young Adults Cochlear Implant (TAYACI) study investigates the long-term outcomes of early implantation and factors influencing variability among cochlear implant (CI) users. This article outlines participants' background, early language outcomes, and multidisciplinary study protocol.

Neuromuscular Blocking Agents and Tracheal Intubation: Systematic Review and Meta-Analysis of Effects on Laryngeal Complications and Intubating Conditions.

Background And Aims: The use of neuromuscular blocking agents (NMBAs) in tracheal intubation is widely accepted in anesthetic induction, but adverse effects are possible. We performed a systematic review and meta-analysis to compare influence of use and nonuse of NMBAs on incidence of laryngeal complications and intubating conditions in surgical patients.

Methods: We searched PubMed, Web of Science, Embase, and Cochrane Library for randomized controlled trials comparing use of NMBAs with either placebo or no treatment for oral tracheal intubation in adult patients under general anesthesia.