Vocal Fatigue and Recovery Patterns Among Call Center Operators: A Workday Progression Study.

Objective: Call centers in India, rely heavily on call center operators' (CCO) vocal abilities, putting them on a high vocal demand and the related risk of voice-related problems. This study investigated vocal changes among CCOs during a workday.

Method: Fifty CCOs from various sectors participated undergoing evaluation, including acoustical, perceptual, aerodynamic, and self-perceptual measures.

Juvenile-onset systemic lupus erythematosus with multisystem involvement complicated by posterior reversible encephalopathy syndrome (PRES).

A previously healthy girl in her middle childhood of African origin presented with a 2-week history of fever and sore throat. Initial tests showed pancytopenia and proteinuria while the septic screen was negative except for the presence of parvovirus B19 infection. When her symptoms persisted, the possibility of an underlying connective tissue disorder such as systemic lupus erythematosus (SLE) was explored and confirmed.

[Research progress of aldehyde dehydrogenase type 2 in head and neck malignant tumors].

Alcohol is a high-risk factor of the head and neck tumor, and acetaldehyde dehydrogenase type 2（ALDH2） is an important alcohol metabolism enzyme in the human body, whose function is to metabolize acetaldehyde into non-toxic acetic acid in the human body. Studies have shown that ALDH2 gene polymorphisms increase the risk of head and neck tumors by affecting enzyme activity to regulate the rate of alcohol metabolism in the body, and high levels of ALDH2 expression are beneficial for enhancing head and neck tumor immunity and improve prognosis. This article aims to review the research progress on the relationship between ALDH2 and the occurrence and treatment of head and neck tumors.

[A successful interventional treatment of recurrent bleeding after tonsil surgery in children].

The patient, a 10-year-old and 4-month-old boy, was admitted to the hospital "with a history of 19 days since tonsil surgery and 11 days of recurrent hematemesis". 19 days ago, bilateral endoscopic tonsil + adenoid plasma melting and bilateral tonsil fossa inferior pole suture were performed in the outer hospital, and recurrent hematemesis occurred 11 days ago, accompanied by transient fatigue and abdominal pain, diagnosis: ①Hematemesis to be investigated: postoperative tonsil bleeding? Upper gastrointestinal bleeding?②Acute moderate hemorrhagic anemia. On the first and third days of admission, the child had two sudden episodes of massive hematemesis, both of which were more than 1 000 mL, with pale lips, fatigue, and hemorrhagic shock.

The impact of non-pharmacological interventions on nasopharyngeal , , , carriage and the change of pneumococcal vaccination in healthy children under 5 years old in Beijing, China.

Background: We analyzed the impact of non-pharmacological interventions (NPIs) and PCV13 inoculation on nasopharyngeal (NP) carriage of (Sa), (Sp), (Mc), and (Hi) in healthy children under 5-years-old in Beijing, China.

Research Design And Methods: NP swabs were taken from healthy children seeking routine well-child care at the pediatric preventive health clinic. NP swabs were frozen in Tryptic Soy Broth (TSB) medium and stored at -80°C, and bacterial was detected by culture.

A Quality Improvement Initiative to Reduce Opioid Use Following Routine Thyroid and Parathyroid Surgery.

Objective: Evaluate the postoperative pain management of patients at a single institution following routine thyroid and parathyroid surgery and compare patient opioid use before and after a practice wide quality improvement change.

Study Design: Retrospective chart review with prospective survey administration.

Setting: University of New Mexico Hospital.

Doxycycline Postexposure Prophylaxis for Bacterial STIs: Prescribing Patterns, Use, Short-term Outcomes Among 2083 Patients in a Los Angeles Federally Qualified Health Care Program, and Implications for Widespread Use.

Background: Rates of bacterial sexually transmitted infections (STIs) have risen dramatically over the past decades. Doxycycline postexposure prophylaxis (DP) is a novel intervention to prevent bacterial STIs. Recent randomized controlled clinical trials reported high DP efficacy at preventing syphilis and chlamydia in cisgender men who have sex with men and transgender women.

Development of clinical practice guidelines and primary care referral pathways for management of otorhinolaryngological conditions in Pakistan.

Background: Diseases of the ear, nose, and throat (ENT) account for a significant portion of a primary care physician's practice in Pakistan, a South Asian lower-middle income country. This increasing burden demands comprehensive clinical practice guidelines and primary care clinical referral algorithms to be devised so that general physicians can adequately provide standardized primary health care and prevent needless specialist ENT referrals.

Methods: We selected eight guidelines regarding epistaxis, neck masses, hearing loss, Meniere's disease, dysphonia, allergic rhinitis, acute otitis externa, and rhinosinusitis from the American Academy of Otolaryngology-Head and Neck Surgery Foundation as the source guidelines and employed the GRADE-ADOLOPMENT approach to contextualize guidelines by adopting, adapting, or excluding recommendations from these guidelines.

High nasopharyngeal and serum IL-6 levels and the - 573G > C polymorphism (rs1800796) are linked with the risk of severe COVID-19 in a Mexican population: a case‒control study.

Background: COVID-19 was the leading cause of death in Mexico between 2020 and 2021. SARS-CoV-2 infection varies widely among individuals and populations. Since variations in genes related to the immune response may play a role in the susceptibility to and outcome of COVID-19, the associations of gene polymorphisms (SNPs) of IL-6 (- 573G > C, rs1800796), TNF-α (- 308G > A, rs1800629), and IFN-γ (- 1615 C > T, rs2069705) with the expression levels of these proteins in the nasopharynx and serum were evaluated in a Mexican population with mild, severe, or critical COVID-19.

Effect of pore-throat structure on movable fluid and gas-water seepage in tight sandstone from the southeastern Ordos Basin, China.

This study investigates the micro-pore-throat structure of Upper Paleozoic tight sandstone gas reservoirs in the southeastern Ordos Basin, China, with a focus on the Yan'an gas field. The aim is to analyze the micro-pore-throat characteristics and their influence on fluid seepage to optimize gas-water two-phase flow, reservoir evaluation, and development strategies. The research integrates core analysis, thin section petrography, FE-SEM, MICP, NMR, and gas-water relative permeability tests.

Performance assessment of disposable carbon-based immunosensors for the detection of SARS-CoV-2 infections.

We designed, developed, and clinically tested two rapid antigen-based immunosensors for SARS-CoV-2 detection, enabling diagnosis and viral load quantification for under USD $2. In a first clinical study, a screen-printed disposable carbon-based (SPC) sensor was assessed on prospectively recruited adult participants classified into three study groups: healthy donors (n = 46); SARS-CoV-2-infected symptomatic patients (n = 58); and co-habitants of patients without prior testing (n = 38). Nasopharyngeal aspirates (NA), oropharyngeal swabs (OS), and saliva (SA) samples were obtained from all participants.

Amended diagnosis of the genus Provitellotrema (Digenea: Haplosplanchnidae) with description of a new species from vietnamese mullets.

Morphological and molecular data for a new representative of the genus Provitellotrema (Haplosplanchnidae) from the mullets of the coastal waters of Vietnam were provided in the present study. Morphologically, the trematodes described here are similar to representatives of Haplosplanchnus and Pseudohaplosplanchnus and demonstrate the most closeness to Haplosplanchnus purii by most of the metric parameters. Results of molecular phylogenetic analysis show that the trematodes we found were closely related to Provitellotrema crenimugilis, and H.

A mixed methods protocol for an impact and implementation evaluation of the Pharmacy First Services for management of common conditions in England.

Objectives: In response to high levels of demand for primary medical services in England, characterized by longer appointment waiting times and delayed referrals, the Government developed its National Health Service (NHS) Primary Care Recovery Plan. A key component of the plan is Pharmacy First (PF), which involves participating community pharmacies supplying prescription-only medicine after consultation with a pharmacist for seven common conditions: earache, uncomplicated urinary tract infections in women, sore throat, sinusitis, impetigo, shingles, and infected insect bites. The study aims to evaluate the implementation of the PF service and its impact on the volume of prescribing, case mix of General Practitioner consultations, accident and emergency department and other hospital use, equity of access, and cost for different groups of patients in different contexts, as well as its acceptability and fidelity.

Pocket guide: biologics in upper and lower airways in adults.

The introduction of biologics for the treatment of severe upper and lower (type 2) airway inflammation has been a gamechanger in the management of these diseases. Biologics are injectable medications targeting different molecules relevant in (type 2) inflammation in patients with severe (type 2) airway diseases, like asthma, eosinophilic chronic obstructive pulmonary disease (COPD), chronic rhinosinusitis (CRS) and those who remain uncontrolled despite regular treatment (1-3). After the phase 3 trials, showing significant impact on symptoms, quality of life and interventions like surgery (for the upper airways) and exacerbations needing hospitalisation (for the lower airways), biologics are now used in daily practice in many parts of the world (4, 5).

The prevalence of primary chronic rhinosinusitis in young adults from a Swedish birth cohort.

Background: Chronic rhinosinusitis (CRS) is common worldwide but scarcely studied among young adults. The aim was to investigate prevalence, clinical features, comorbidity, and mucosal inflammatory patterns of CRS among 24-year-olds in a populationbased study.

Method: 3037 subjects from the birth cohort BAMSE (Barn/children Allergy Milieu Stockholm Epidemiology) had complete questionnaire answers on CRS at the 24-year-follow-up.

Effects of Therapeutic Antibiotic Exposure on the Oropharyngeal and Fecal Microbiota in Infants With Cystic Fibrosis.

Background: Systemic antibiotics can impact all microbes inhabiting patients, regardless of the intended target organism(s). We studied the simultaneous effects on respiratory and fecal microbiomes of β-lactam antibiotics administered for respiratory symptoms in infants with cystic fibrosis (IWCF).

Objective: To compare the magnitude and duration of intended (respiratory) and unintended (fecal) antimicrobial action by analyzing oropharyngeal (OP) and fecal microbiota in IWCF.

Successful Conservative Management of Thyroid Rupture and Haematoma Following Blunt Cervical Trauma: A Case Report.

Parenchymal organ rupture is a serious emergency condition most commonly occurring in abdominal or thoracic viscera, whereas blunt neck trauma affecting the thyroid is rarely documented. We present the case of a 43-year-old male who sustained a blunt cervical trauma and presented with neck haematoma, respiratory discomfort, and hoarseness. The diagnosis of thyroid gland rupture of the left lobe was made via ultrasonography and computed sonography scans.

Detection of Pharyngolaryngeal Activities in Real-World Settings Using Wearable Sensors.

Automatic detection and identification of pharynxgolaryngeal activities (PLA) such as swallowing, speaking, and coughing, are crucial steps in developing a system for diagnosing dysphagia (swallowing disorders) using high-resolution cervical auscultation (HRCA) signals. Using sensors placed on the throat, HRCA provides clinicians with a non-invasive means of assessing swallowing. This study introduces a new approach based on depthwise CNN and LSTM networks to automatically detect and identify PLA in synchronized accelerometer and microphone signals.

Grade classification of nasal obstruction from endoscopy videos using machine learning.

Nasal obstruction (NO), referring to blockage in the nasal cavity, is prevalent, affecting approximately one-third of the adult population. Consequently, diagnosis typically requires a combination of medical imaging techniques and tests, as NO is often subjective. This study aims to automate the grade classification of NO from anterior nasal cavity images using nasal endoscopy as a standalone diagnostic tool for common NO conditions: allergic rhinitis, chronic rhinosinusitis, and deviated nasal septum.

Oropharyngeal Staphylococcus aureus is linked to higher mortality in long-term aged care residents.

Background: Biological ageing, healthcare interactions, and pharmaceutical and environmental exposures in later life alter the characteristics of the oropharyngeal (OP) microbiome. These changes, including an increased susceptibility to colonisation by pathobiont species, have been linked with diverse health outcomes.

Objectives: To investigate the relationship between OP microbiome characteristics and all-cause mortality in long-term aged care residents.

IgA Nephropathy and the Risk of Primary Infections: A Swedish population-based cohort study.

Background: IgA nephropathy is the most common primary kidney disease in the world and has a highly variable clinical presentation. While studies have indicated a link between glomerular disease and infections, large-scale studies on IgA nephropathy are missing.

Methods: In our study, IgA nephropathy was defined as having a kidney biopsy record 1997-2011 in Sweden.

Identifying novel inhibitors against drug-resistant mutant CYP-51 Candida albicans: A computational study to combat fungal infections.

Candida albicans (C. albicans) is an opportunistic pathogen in immunocompromised individuals and a normal inhabitant of the oral cavity, throat, gastrointestinal tract, and genitourinary system among health populations. Our study focused on identifying new inhibitors capable of binding to the mutant cytochrome P450 family 51 (CYP-51) protein and intended to be effective against resistant C.

Risk of early death after treatment with curative intent for head and neck squamous cell carcinoma: a retrospective population-based study.

Background And Purpose: Knowledge regarding the risk factors for early death in patients with head and neck squamous cell carcinoma (HNSCC) is scarce. This study aims to evaluate the rate of early death (during or within 6 months of treatment) and its associated risk factors in HNSCC patients treated with curative intent.

Materials And Methods: A retrospective, population-based analysis of all HNSCC patients (n = 762) treated with curative intent at the Helsinki University Hospital (Helsinki, Finland) during 2012-2015 was conducted.

Development and evaluation of the Digit Triplet Test in Swahili language.

Background:  The development of a Digit Triplet Test in the Swahili language is an essential step towards providing accurate hearing assessment for Swahili-speaking populations.

Objectives:  This study aimed to develop a Digit Triplet Test in Swahili through a two-part procedure consisting of an optimisation phase and an evaluation phase using normal hearing participants.

Method:  A total of 34 subjects participated in the study.