Effects of Acceptance and Commitment Care in the Treatment of Aplastic Anemia Patients with Recombinant Human Thrombopoietin.

Background: This study was designed to determine the effects of acceptance and commitment care in the treatment of aplastic anemia (AA) patients with recombinant human thrombopoietin (rhTPO).

Methods: The clinical records of 100 AA patients treated at our hospital from March 2021 to March 2023 were analyzed in the retrospective study. All patients received immunosuppressants and rhTPO.

Energy-Efficient Collision-Free Machine/AGV Scheduling Using Vehicle Edge Intelligence.

With the widespread use of autonomous guided vehicles (AGVs), avoiding collisions has become a challenging problem. Addressing the issue is not straightforward since production efficiency, collision avoidance, and energy consumption are conflicting factors. This paper proposes a novel edge computing method based on vehicle edge intelligence to solve the energy-efficient collision-free machine/AGV scheduling problem.

Flexible PAN/P25 Multi-Porous Nanotubular Electrospun Membrane Constructed by a Facile Ethylene Glycol Solvothermal Induction with Excellent Photocatalytic Degradation and Sterilization Performance.

A series of flexible polyacrylonitrile/TiO (PAN/P25) multi-porous nanotubular membranes were successfully constructed by facile electrospinning combined with an ethylene glycol solvothermal induce strategy. The effects of P25 dosage and solvothermal time on the morphology of samples were systematically investigated, which were characterized in terms of surface morphology, microstructure, specific surface area, thermal analysis, wettability, photoelectrochemical and fluorescence spectra. Rhodamine B (RhB) and () were employed as simulated pollutants to evaluate photocatalytic degradation and antibacterial properties of the PAN/P25-3 multi-porous nanotubular membrane.

How Will Concrete Piles for Offshore Wind Power Be Damaged Under Seawater Erosion? Insights from a Chemical-Damage Coupling Meshless Method.

Based on the background of the continuously rising global demand for clean energy, offshore wind power, as an important form of renewable energy utilization, is booming. However, the pile foundations of offshore wind turbines are subject to long-term erosion in the harsh marine environment, and the problem of corrosion damage is prominent, which seriously threatens the safe and stable operation of the wind power system. In view of this, a meshless numerical simulation method based on smoothed particle hydrodynamics (SPH) and a method for generating the concrete meso-structures are developed.

Effect of TiO Coating on Structure and Electrochemical Performance of LiNiCoMnO Cathode Material for Lithium-Ion Batteries.

High-nickel ternary LiNiCoMnO (NCM622) is a promising cathode material for lithium-ion batteries due to its high discharge-specific capacity and energy density. However, problems of NCM622 materials, such as unstable surface structure, lithium-nickel co-segregation, and intergranular cracking, led to a decrease in the cycling performance of the material and an inability to fully utilize high specific capacity. Surface coating was the primary approach to address these problems.

Relationship Between the Carbonation Depth and Microstructure of Concrete Under Freeze-Thaw Conditions.

Concrete structures in cold regions are affected by freeze-thaw cycles (FTCs) and carbonation, which lead to the premature failure of concrete structures. The carbonation depth, relative dynamic elastic modulus (RDEM), compressive strength, porosity, and pore size distribution of concrete under FTC conditions were tested through an accelerated carbonation experiment to study the carbonation performance evolution. The freeze-thaw effect mechanism on concrete carbonation was further analyzed via the obtained relationship between carbonation depth and pore structure.

Citri reticulate pericranium-derived extracellular vesicles exert antioxidant and anti-inflammatory properties and enhance the bioactivity of nobiletin by forming EVs-nob nanoparticles.

Plant-driven extracellular vesicles (PEVs) have attracted significant interest due to their natural origin, remarkable bioactivity, and efficacy in drug encapsulation and target delivery. In our work, extracellular vesicles from Citri Reticulate Pericranium (CEVs) were isolated and investigated their physicochemical characteristics and biological activities. We identified the vesicle structures as regular, with a particle size of approximately 200 nm.

The relationship between compulsory citizenship behavior and nurses' silence: a cross-sectional study.

Aim: This study aimed to assess the relationship between compulsory citizenship behavior and nurses' silence.

Methods: A descriptive cross-sectional online study was conducted in October 2023, targeting 402 nurses working in Yichang Central People's Hospital, Hubei Province, China. Data were collected through a structured questionnaire comprising demographic details, the Compulsory Citizenship Behavior Scale, and the Nurses' Silence Scale.

Synthesis of N-doped Carbon Quantum Dots as an Effective Fluorescent Sensor of Fe Ions and a Potent Antibacterial Agent.

In this study, a simple and efficient method for synthesizing nitrogen-doped carbon quantum dots (N-CQDs) has been developed through a one-step hydrothermal process using hedyotis diffusa willd. The morphology, chemical composition, and optical properties of the resulting N-CQDs were thoroughly characterized. The synthesized N-CQDs exhibited a spherical shape with an average particle size of 4.

Diagnostic Accuracy of FEF for Bronchial Hyperresponsiveness in Patients with Suspected Asthma and/or Allergic Rhinitis: A Systematic Review and Meta-analysis.

Background: Some studies have suggested that the forced expiratory flow between 25 and 75% of vital capacity (FEF) can be used as an early marker of bronchial hyperresponsiveness (BHR) in asthma and allergic rhinitis (AR), but is highly variable. Here, we aimed to assess whether the FEF can be used to diagnose BHR in patients with asthma-like symptoms and AR.

Methods: PubMed, EMBASE, Web of Science, Wiley Online Library, Cochrane Library, SinoMed, CNKI, and Wanfang Data were searched to acquire eligible studies.

Unveiling ADAMTS12: A key driver of bladder cancer progression via COL3A1-Mediated activation of the FAK/PI3K/AKT signaling pathway.

Bladder cancer (BCa) is a common and lethal disease characterized by high recurrence rates and limited treatment options. Understanding the molecular pathways of BCa progress is crucial for investigating more effective targeted therapies. While ADAMTS12 is known to contribute to cancer progression and treatment resistance, its prognostic significance and underlying mechanisms in BCa remain poorly understood.

Contrast-associated acute kidney injury in patients with diabetes mellitus following elective percutaneous coronary intervention: Insights from an iodixanol-acute kidney injury registry study.

Background: Patients with diabetes mellitus (DM) are particularly susceptible to contrast-associated acute kidney injury (CA-AKI). However, few studies have evaluated CA-AKI stages in patients with DM following elective percutaneous coronary intervention (PCI) with iodixanol.

Methods: Patients with DM who underwent elective PCI in 8 Chinese hospitals from May 2020 to November 2021 were prospectively enrolled in the Iodixanol-Acute Kidney Injury Registry (No.

Aberrant Cortical Morphological Networks in First-Episode Schizophrenia.

Background And Hypothesis: Population-based morphological covariance networks are widely reported to be altered in schizophrenia. Individualized morphological brain network approaches have emerged recently. We hypothesize that individualized morphological brain networks are disrupted in schizophrenia.

Copper-luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease.

Oxidative stress, dysbiosis, and immune dysregulation have been confirmed to play pivotal roles in the complex pathogenesis of inflammatory bowel disease (IBD). Herein, we design copper ion-luteolin nanocomplexes (CuL NCs) through a metal-polyphenol coordination strategy, which plays a multifaceted role in the amelioration of IBD. The fabricated CuL NCs function as therapeutic agents with exceptional antioxidant and anti-inflammatory capabilities because of their great stability and capacity to scavenge reactive oxygen species (ROS).

Ferroptosis-related Biotargets and Network Mechanisms of Maslinic Acid Against Myocardial Ischemia-reperfusion Injury: An Integrated Bioinformatic and Experimental Approach.

Background: Maslinic acid (MA), a pentacyclic triterpenoid compound derived from leaves and fruits of Olea europaea, bears multi-pharmacological properties. Our previous studies found that MA exerted a cardioprotective effect by modulating oxidative stress, inflammation, and apoptosis during myocardial ischemia-reperfusion injury (MIRI). Nevertheless, data regarding the anti-ferroptosis effects of MA on MI/RI remains unidentified.

Ultrasound nanobubble-based combinational strategies of loaded miR-107-3p and CD133 Ab for anti-PD-L1 and anti-hepatocellular cancer stem cells.

Background: CD133 is regarded as a marker and target for cancer stem cells (CSCs) in various types of tumors, including hepatocellular carcinoma (HCC). The expressions of CD133 and programmed cell death ligand 1 (PD-L1) in CSCs exhibit a positive feedback regulatory effect. This effect promotes CSC proliferation and immune escape, ultimately leading to tumor progression and poor prognosis.

Utilizing zebrafish models to elucidate mechanisms and develop therapies for skeletal muscle atrophy.

Skeletal muscle atrophy, resulting from an imbalance in muscle protein synthesis and degradation, compromises muscle quality and function, imposing significant burdens on movement and metabolic stability. Animal models are crucial for understanding the mechanisms of skeletal muscle atrophy and developing clinical prevention and treatment strategies. Zebrafish, as small aquatic vertebrates, exhibit high genetic homology with humans and offer advantages such as rapid reproduction, development, and transparent embryos.

Removal of mixed PhACs by combined UV/HO and biologically activated carbon process: Toxicity assessment, transformation products and microbial community.

This study examined the removal and toxicity reduction of mixed pharmaceutically active compounds (PhACs), including carbamazepine, erythromycin, gemfibrozil, and diclofenac, in the UV/HO tandem with biologically activated carbon (UV/HO-BAC) process and explored potential detoxification mechanisms. Results indicated that the combined process effectively removed the mixed PhACs, with the UV/HO segment being the primary contributor. As distinct from concentration removal, the effluent toxicity significantly increased after UV/HO treatment.

Resazurin-based fluorescent probe for mercury ions and its applications in environment and biological systems.

Mercury is considered to be one of the most typical and toxic elements of heavy metals in the environment, threatening human health even at very low level. For this reason, we developed a new fluorescence-enhanced probe RTQ based on resazurin dye, which realizes the selective detection of Hg by using carbonothioate group as the recognition receptor. Probe RTQ can quantitatively assay Hg ranging from 0-0.

LDL-cholesterol lowering agents (statins and PCSK9 inhibitors) and the risk of intracerebral hemorrhage: A network meta-analysis.

Background And Purpose: Statin therapy reduces the risk of ischemic stroke; however, certain studies have observed an increased incidence of intracerebral hemorrhage (ICH). Moreover, proprotein convertase subtilisin/kexin type 9(PCSK-9) inhibitors have emerged as a powerful class of lipid-lowering medications, potentially with a lower propensity for causing hemorrhagic events. To investigate this matter further, we conducted a network meta-analysis of randomized controlled trials (RCTs) involving statins and PCSK-9 inhibitors that reported occurrences of ICH.

Decoding Epilepsy: Prickle2 and Multifaceted Molecular Pathway Connections.

Background: The Prickle2 (Pk2) gene shows promising potential in uncovering the underlying causes of epilepsy, a neurological disorder that is currently not well understood. This paper utilizes the online tool PubMed to gather and condense information on the involvement of PCP channels and the associated roles of PCP pathway molecules in the onset of epilepsy. These findings are significant for advancing epilepsy treatment.

Effect of transcutaneous vagus nerve stimulation in hemodialysis patients: A randomized controlled trial.

Introduction: Transcutaneous auricular vagus nerve stimulation (tVNS) has shown potential in neurological, autoimmune, and cardiovascular disorders, but its effects on HD patients remain unclear. This study aimed to evaluate the efficacy and safety of tVNS in HD patients.

Methods: We conducted a randomized controlled clinical trial on patients receiving HD ≥6 months.

Phase 2 study of serplulimab with the bevacizumab biosimilar HLX04 in the first-line treatment of advanced hepatocellular carcinoma.

Introduction: This study aimed to evaluate the safety and preliminary efficacy of serplulimab, a novel programmed death-1 inhibitor, with or without bevacizumab biosimilar HLX04 as first-line treatment in patients with advanced hepatocellular carcinoma.

Methods: This open-label, multicenter phase 2 study (clinicaltrials.gov identifier NCT03973112) was conducted in China and consisted of four treatment groups: group A (serplulimab 3 mg/kg plus HLX04 5 mg/kg, subsequent-line), group B (serplulimab 3 mg/kg plus HLX04 10 mg/kg, subsequent-line), group C (serplulimab 3 mg/kg, subsequent-line) and group D (serplulimab 3 mg/kg plus HLX04 10 mg/kg, first-line).