Removal of Antibiotics in Breeding Wastewater Tailwater Using Microalgae-Based Process.

Ciprofloxacin (CIP) and oxytetracycline (OTC) are commonly detected antibiotic species in breeding wastewater, and microalgae-based antibiotic treatment technology is an environmentally friendly and cost-effective method for its removal. This study evaluated the effects of CIP and OTC on Scenedesmus sp. in the breeding wastewater tailwater and the removal mechanisms of antibiotics.

Pifithrin-μ sensitizes mTOR-activated liver cancer to sorafenib treatment.

TSC2, a suppressor of mTOR, is inactivated in up to 20% of HBV-associated liver cancer. This subtype of liver cancer is associated with aggressive behavior and early recurrence after hepatectomy. Being the first targeted regimen for advanced liver cancer, sorafenib has limited efficacy in HBV-positive patients.

Ultrasound and CT-guided implantation of iodine-125 seeds combined with transarterial chemoembolization for recurrent hepatocellular carcinoma at complex sites after hepatectomy.

Objective: The objective of this study was to evaluate the efficacy and safety of TACE combined with 125I seeds (TACE-125I) in the treatment of recurrent HCC at complex sites after hepatectomy.

Methods: This study retrospectively analyzed the clinical data of recurrent HCC patients located at complex sites (such as large blood vessels, diaphragm dome, etc.) after hepatectomy from January 2012 to December 2023, all of whom received TACE-125I or TACE therapy.

A single-cell sequencing-based analysis of a 13-year-old with maxillary sinus NUT carcinoma.

NUT carcinoma is a rare and highly aggressive malignancy, predominantly affecting adolescents and young adults. This tumor demonstrates rapid progression, resistance to conventional anti-cancer treatments, and an extremely poor prognosis. Currently, research on NUT carcinoma is limited, and effective treatment options remain scarce.

Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis.

Multiple sclerosis (MS) is a chronic autoimmune disorder marked by neuroinflammation, demyelination, and neuronal damage. Recent advancements highlight a novel interaction between iron-dependent cell death, known as ferroptosis, and gut microbiota, which may significantly influences the pathophysiology of MS. Ferroptosis, driven by lipid peroxidation and tightly linked to iron metabolism, is a pivotal contributor to the oxidative stress observed in MS.

Retrospective Analysis of the Correlation between Umbilical Blood Flow Index and Maternal and Fetal Outcomes in Pregnant Women with Gestational Diabetes.

Gestational diabetes mellitus (GDM) is a common complication during pregnancy. This retrospective study investigates the correlation between umbilical blood flow index and maternal-fetal outcomes in pregnant women with GDM, aiming to contribute to evidence-based risk assessment and management strategy in this high-risk obstetric population. This retrospective study recruited 119 pregnant women with GDM who were admitted to the Yichang Central People's Hospital, between January 2022 and January 2024.

Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer.

Background: Metastasis is a leading cause of cancer-related death in castration-resistant prostate cancer (CRPC) patients. Circular RNAs (circRNAs) have emerged as key regulators of the metastasis of various cancers. However, the functional effects and regulatory mechanisms of circRNAs in metastatic CRPC (mCRPC) remain largely unknown.

Research on the bearing performance of HSCA high-strength preloaded expansion piles in calcareous sand foundation.

With the rapid development of infrastructure construction on oceanic reefs, calcareous sand, as the primary medium of these reefs, exhibits unique physical and mechanical properties such as high void ratio, low strength, and susceptibility to particle breakage. These characteristics reduce the bearing capacity and stability of pile foundations in calcareous sand foundations. This study investigates the bearing characteristics of high-strength preloaded expansion piles in calcareous sand foundations, taking into account the influence of HSCA high-performance expansion agent dosage through a series of indoor model tests and in-situ tests.

Tool wear prediction based on XGBoost feature selection combined with PSO-BP network.

To address the challenge of accurately capturing tool wear states in small sample scenarios, this paper proposes a tool wear prediction method that combines XGBoost feature selection with a PSO-BP network. In order to solve the problem of input feature selection and parameter selection in BP neural network, a double-layer programming model of input feature and parameter selection is established, which is solved by XGBoost and PSO. Initially, vibration and cutting force signals from CNC machining are preprocessed using time-domain segmentation, Hampel filtering, and wavelet denoising.

Bearing characteristics and continuous-discontinuous numerical analysis of a pressure grouting pile in a calcareous sand foundation.

The complex mechanical characteristics of calcareous sand complicate comprehensive analysis of the bearing characteristics of pressure grouting piles. The bearing mechanism of pressure grouting piles is unclear. Field tests of the bearing characteristics of pressure grouting piles in calcareous sand foundations were carried out.

Study on the reforming performance of liquid products from biomass staged gasification based on component analysis and simulation.

Biomass staged gasification technology (BSGT) divides the traditional gasification into medium-temperature devolatilization (MTD) stage, high-temperature gasification (HTG) stage and high-temperature reforming (HTR) stage. The present study conducted MTD and HTG experiments on corn stalks and focused on the effect of MTD at 200-550 °C on the reforming performance of BSGT liquid products through component analysis and simulation. The results demonstrate that the MTD temperature above 350 °C could prevent the participation of phenols and oxygen in HTG and HTR stages, respectively, thereby improving the reforming performance of BSGT liquid products and the quality of BSGT syngas.

3D Mechanical Response Stem Cell Complex Repairs Spinal Cord Injury by Promoting Neurogenesis and Regulating Tissue Homeostasis.

Spinal cord injury (SCI) leads to acute tissue damage that disrupts the microenvironmental homeostasis of the spinal cord, inhibiting cell survival and function, and thereby undermining treatment efficacy. Traditional stem cell therapies have limited success in SCI, due to the difficulties in maintaining cell survival and inducing sustained differentiation into neural lineages. A new solution may arise from controlling the fate of stem cells by creating an appropriate mechanical microenvironment.

Photooxidation Cross-Linked, Glutaraldehyde Cross-Linked, or Enzyme and Hydrostatic Pressure Processed Decellularized Biomaterials for Cardiovascular Repair Do Not Affect Host Response in a Rat Right Ventricular Outflow Flow Tract Reconstruction (RVOT) Model.

Cardiovascular diseases (CVDs) were responsible for approximately 19 million deaths in 2020, marking an increase of 18.7% since 2010. Biological decellularized patches are common therapeutic solutions for CVD such as cardiac and valve defects.

Study on Crack Resistance Mechanism of Helical Carbon Nanotubes in Nanocomposites.

Helical carbon nanotubes (HCNTs) with different geometrical properties were constructed and incorporated into nanocomposites for the investigation of the anti-crack mechanism. The interfacial mechanical properties of the nanocomposites reinforced with straight carbon nanotubes and various types of HCNTs were investigated through the pullout of HCNTs in the crack propagation using molecular dynamics (MD). The results show that the pullout force of HCNTs is much higher than that of CNTs because the physical interlock between HCNTs and matrices is much stronger than the van der Waals (vdW) interactions between CNTs and matrices.

The Positive Regulatory Effect of DBT on Lipid Metabolism in Postpartum Dairy Cows.

Background/objectives: The transition from a non-lactating to a lactating state is a critical period for lipid metabolism in dairy cows. Danggui Buxue Tang (DBT), stimulating energy metabolism, ameliorates diseases related to lipid metabolism disorders and is expected to be an effective supplement for alleviating excessive lipid mobilisation in periparturient dairy cows. This study aimed to investigate the effects of supplemental DBT on serum biochemical indices, faecal microbial communities, and plasma metabolites in dairy cows.

A resilience assessment framework for slopes considering multiple performance indicators.

The performance assessment of slopes during various disturbances is important to ensure the safe service of slopes. Due to the four characteristics of slope engineering, it is difficult for existing resilience evaluation models to accurately reflect slope performance. To address this problem, a resilience evaluation model applicable to slopes was developed in this study.

Multilayer entropy-weighted TOPSIS method and its decision-making in ecological operation during the subsidence period of the Three Gorges Reservoir.

Coordinating the downstream ecological demand and the power generation demand of hydropower stations is an important task in the operation of reservoirs, and how to evaluate the ecological satisfaction of the scheduling process is a difficult problem that needs to be solved urgently. A multi-objective optimal reservoir scheduling model was constructed to coordinate the spawning flow demand of " Four Major Chinese Carps"; The model takes the maximum power generation and the maximum membership degree of downstream river ecological water demand as the objective functions, and uses the dynamic programming multi-objective solution algorithm based on penalty factors to solve the problem, and obtains the non-inferior solution set in each scenario. The multilayer entropy-weighted TOPSIS method was used to study the non-inferior solution of the multi-objective scheduling model of the Three Gorges Reservoir, and the satisfactory solution ranking of the river flow rise process, ecological flow-related requirements, and power generation water requirements was obtained under the four schemes including 4d ~ 7d, which improved the reliability of the evaluation results and made up for the shortcomings of the traditional TOPSIS method in terms of hierarchy and weight science.

Conversion Surgery for Initially Unresectable Stage Ⅲ Nonsmall Cell Lung Cancer After Induction Treatment of Immunochemotherapy: A Multicenter Study.

Background: Immuno-chemotherapy has demonstrated significant anti-tumor effects in patients with resectable nonsmall cell lung cancer (NSCLC). Additionally, for patients initially diagnosed with unresectable stage III NSCLC, induction immuno-chemotherapy may achieve tumor downstaging, enabling conversion to resectable disease allowing for by R0 resection. This study aimed to assess the effectiveness and safety of induction immuno-chemotherapy followed by conversion surgery in unresectable stage III NSCLC.

β-Sitosterol modulates osteogenic and adipogenic balance in BMSCs to suppress osteoporosis via regulating mTOR-IMP1-Adipoq axis.

Background: Osteoporosis (OP) is a prevalent global health concern, impacting millions of individuals, especially the elderly. The etiology of senile OP is associated with the imbalance of osteogenic and adipogenic differentiation in the bone marrow mesenchymal stem cells (BMSCs). The imbalance of BMSCs differentiation fate will leading to bone loss and lipids accumulation.

Regulating gypsum scaling-induced wetting in membrane distillation by heterogeneous crystallization: Role of filter media.

Mineral scaling and scaling-induced wetting are critical issues in membrane distillation (MD) during treatment of saline wastewaters. Gypsum scaling and scaling-induced wetting in MD were successfully regulated by heterogeneous crystallization with in-line granular filtration in this study. Stable water recovery increased from 32.

Comparison of the efficacy of the modified internal brace and the arthroscopic Broström-Gould procedure for chronic lateral ankle instability.

Purpose: To compare the efficacy of an internal brace and the arthroscopic Broström-Gould procedure for chronic lateral ankle instability (CLAI).

Methods: The clinical data of 71 patients who were diagnosed with chronic lateral ankle instability between May 2020 and May 2022 were retrospectively analyzed. The American Orthopedic Foot and Ankle Society (AOFAS) scale, Foot and Ankle Ability Measure (FAAM), and Visual Analogue Scale (VAS) were used to assess clinical outcomes.

Utilization of Stable and Efficient High-Entropy (NiZnMgCuCo)AlO Catalyst with Polyvalent Transition Metals to Boost Peroxymonosulfate Activation toward Pollutant Degradation.

A polyacrylamide gel method has been used to synthesize a variety of polyvalent-transition-metal-doped Ni position of high entropy spinel oxides (NiZnMgCuCo)AlO-800 °C (A) on the basis of NiAlO, and the catalytic activity of A is studied under the synergistic action of peroxymonosulfate (PMS) activation and simulated sunlight. The A containing polyvalent transition metals (Ni, Cu, and Co) can effectively activate PMS and efficiently degrade levofloxacin (LEV) and tetracycline hydrochloride (TCH) under simulated sunlight irradiation. After 90 min of light exposure, the degradation percentages of LEV (50 mg L) and TCH (100 mg L) degrade by the A/PMS/vis system reach 87.

Differential Risk Profiles of Incident Abdominal Aortic Aneurysms in Specific Subgroups: A Large Cohort-based Study.

Objective: The aim of this study is to explore the risk profiles associated with Abdominal aortic aneurysm (AAA) incidence in both the general population and diverse subpopulations.

Summary Background Data: AAA is a life-threatening arterial disease, and there is limited understanding of its etiological spectrum across the age, sex, and genetic risk subgroups, making early prevention efforts more complicated.

Methods: This study encompassed a sample size of 364399 participants from the UK.

Effects of rosemary extract and its residue on production, immune performance, and gut microbiota in geese.

Introduction: To explore the effects of rosemary extract (RE) and its residue (RR) on the production, immune performance, and gut microbiota of geese.

Methods: We treat 28-day-old Sichuan white geese ( = 180) with three diets: (1) basal diet (control), (2) basal diet supplemented with 0.02% RE, and (3) basal diet supplemented with 15% RR for 42 days.