401 results match your criteria: "Third Hospital Avenue[Affiliation]"
Sci Rep
September 2020
Department of Ophthalmology, University of Tokyo, Tokyo, Japan.
In humans, the longitudinal characterisation of early optic nerve head (ONH) damage in ocular hypertension (OHT) is difficult as patients with glaucoma usually have structural ONH damage at the time of diagnosis. Previous studies assessed glaucomatous ONH cupping by measuring the anterior lamina cribrosa depth (LCD) and minimal rim width (MRW) using optical coherence tomography (OCT). In this study, we induced OHT by repeated intracameral microbead injections in 16 cynomolgus primates (10 unilateral; 6 bilateral) and assessed the structural changes of the ONH longitudinally to observe early changes.
View Article and Find Full Text PDFEye (Lond)
December 2020
Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Our aim is to review current and significant articles on contact lens wear in keratoconus patients. A comprehensive literature search of PubMed was performed for the following topics on contact lens wear in keratoconus patients: (1) characteristics of contact lens wearers, (2) safety and efficacy, (3) complications, (4) fitting techniques, (5) contact lens wear after procedures/surgeries, (6) patient satisfaction. A total of 104 studies were finally selected and reviewed.
View Article and Find Full Text PDFJ Adv Res
July 2020
Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751, Singapore.
Corneal dystrophies are a group of genetically inherited disorders with mutations in the gene affecting the Bowman's membrane and the corneal stroma. The mutant TGFBIp is highly aggregation-prone and is deposited in the cornea. Depending on the type of mutation the protein deposits may vary (amyloid, amorphous powdery aggregate or a mixed form of both), making the cornea opaque and thereby decreases visual acuity.
View Article and Find Full Text PDFSci Total Environ
October 2020
Eye & Retina Surgeons, 38 Irrawaddy Road #07-63, Mount Elizabeth Novena Specialist Centre, Singapore 329563, Singapore; Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751, Singapore.
Graefes Arch Clin Exp Ophthalmol
August 2020
Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, Singapore.
Purpose: To identify common optical coherence tomography (OCT) characteristics of taxane-related CME (T-CME) to differentiate it from CME associated with other causes (O-CME) and to present multimodal imaging findings of T-CME.
Methods: To differentiate T-CME from O-CME, pooled SD-OCT images from 14 previous publications and images obtained from our multicenter case series of 3 patients with multimodal imaging of T-CME were compared with 16 consecutive cases of O-CME. Images were graded by 2 masked retinal specialists based on the presence of pre-specified OCT characteristics such as CME centered around fovea, outer retinal cysts more prominent compared with inner retinal cysts, continuous outer plexiform layer (OPL) and inner plexiform layer (IPL), intact outer retina layer, attenuation of outer retina layers by overlying retinal layers, and the presence of subretinal fluid.
Sci Rep
March 2020
Singapore Eye Research Institute, 20 College Road, The Academia Building, Singapore, 169856, Singapore.
Protein aggregation has been one of the leading triggers of various disease conditions, such as Alzheimer's, Parkinson's and other amyloidosis. TGFBI-associated corneal dystrophies are protein aggregation disorders in which the mutant TGFBIp aggregates and accumulates in the cornea, leading to a reduction in visual acuity and blindness in severe cases. Currently, the only therapy available is invasive and there is a known recurrence after surgery.
View Article and Find Full Text PDFSci Rep
October 2019
Singapore National Eye Centre (SNEC), 11 Third Hospital Avenue, Singapore, 168751, Singapore.
To clarify the mechanisms and their temporal relationship in the development of proliferative vitreoretinopathy (PVR), we measured vitreous levels of pro-inflammatory cytokines and growth factors in a rabbit model of PVR. PVR was surgically induced in 11 rabbit eyes by vitrectomy, retinotomy, cryotherapy and injection of platelet-rich plasma at baseline. Severity of PVR was assessed on dilated fundal examination with indirect binocular ophthalmoscopy and graded based on the revised experimental PVR classification.
View Article and Find Full Text PDFBiotechnol J
December 2019
Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore.
In recent years, naturally biodegradable polyhydroxyalkanoate (PHA) monopolymers have become focus of public attentions due to their good biocompatibility. However, due to its poor mechanical properties, high production costs, and limited functionality, its applications in materials, energy, and biomedical applications are greatly limited. In recent years, researchers have found that PHA copolymers have better thermal properties, mechanical processability, and physicochemical properties relative to their homopolymers.
View Article and Find Full Text PDFBiomater Sci
November 2019
Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, #08-03 Innovis, Singapore 138634, Singapore. and Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Singapore and Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117575, Singapore.
Anti-vascular endothelial growth factor (anti-VEGF) proteins are the gold-standard treatment for posterior eye segment proliferative vascular diseases such as Age-Related Macular Degeneration (AMD) and Diabetic Retinopathy (DR). However, the standard of care requires inconvenient monthly intravitreal injections. This underlies an unmet clinical need to develop alternative solutions for sustained delivery of biologics.
View Article and Find Full Text PDFCurr Diab Rep
July 2019
Singapore National Eye Centre, Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore, 168751, Singapore.
Purpose Of Review: This paper systematically reviews the recent progress in diabetic retinopathy screening. It provides an integrated overview of the current state of knowledge of emerging techniques using artificial intelligence integration in national screening programs around the world. Existing methodological approaches and research insights are evaluated.
View Article and Find Full Text PDFAm J Ophthalmol Case Rep
September 2019
Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore.
Purpose: To report a case of contact lens-related infectious keratitis caused by the Gram-negative plant pathogen .
Observations: A 26-year old lady with history of contact lens use presented with three weeks history of right eye redness and pain, with the left eye also being involved in the past week. Slit lamp examination of the right eye demonstrated multiple faint subepithelial and stromal infiltrates with no overlying epithelial defect, and no anterior chamber activity.
Sci Rep
March 2019
Singapore Eye Research Institute, Singapore National Eye Center 11 Third Hospital Avenue, Singapore, 168751, Singapore.
Age-related macular degeneration (AMD) - the leading cause of vision loss in the elderly - share many risks factors as atherosclerosis, which exhibits loss of vascular compliance resulting from aging and oxidative stress. Here, we attempt to explore choroidal and retinal vascular compliance in patients with AMD by evaluating dynamic vascular changes using live ocular imaging following treatment with oral sildenafil citrate, a phosphodiesterase type 5 (PDE5) inhibitor and potent vasodilator. Enhanced-depth imaging optical coherence tomography (EDI-OCT) and OCT angiography (OCT-A) were performed on 46 eyes of 23 subjects, including 15 patients with non-exudative AMD in one eye and exudative AMD in the fellow eye, and 8 age-matched control subjects.
View Article and Find Full Text PDFNutrients
March 2019
Singapore Eye Research Institute, Singapore National Eye Centre, 11 Third Hospital Avenue, #06-13, SNEC Bldg, Singapore 168751, Singapore.
The role of leptin (a hormone related to fat mass) in cognition remains equivocal. Our objective was to investigate the relationship between circulating leptin concentration and cognition in older adults, accounting for potential confounders. We categorized 1061 community-dwelling older participants ≥60 years (mean ± SD, 70.
View Article and Find Full Text PDFMacromol Biosci
April 2019
Institute of Materials Research and Engineering, 2 Fusionopolis Way, #08-03 Innovis, Singapore, 138634.
Mediators Inflamm
December 2018
Eye & Vision Health, Flinders University School of Medicine, Rm 4E-431, 1 Flinders Drive, Bedford Park, Adelaide, SA 5042, Australia.
[This corrects the article DOI: 10.1155/2017/3164375.].
View Article and Find Full Text PDFACS Appl Bio Mater
January 2019
Institute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way, #08-03 Innovis, Singapore 138634, Singapore.
Poly(3-hydroxybutyrate) (PHB) is a sustainable and biodegradable biopolymer from bacteria, but its brittle nature greatly limits its applications. In this study, we developed a lignin-PHB copolymer to enhance the mechanical properties of PHB. β-Butyrolactone was grafted onto the lignin core by using solvent-free ring-opening polymerization (ROP).
View Article and Find Full Text PDFPatient
August 2019
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Background: It is not clear whether 5-level EQ-5D (EQ-5D-5L) utilities based on recently developed value sets are more responsive than 3-level EQ-5D (EQ-5D-3L) utilities.
Objectives: The study aims were to compare (1) the responsiveness of EQ-5D-5L and EQ-5D-3L utilities and (2) the responsiveness of these utilities with the Short Form-6 Dimension (SF-6D) and Health Utilities Index Mark 3 (HUI3) utilities to the treatment benefit of cataract surgery.
Methods: A total of 148 patients were interviewed before and after their cataract surgery using EQ-5D-3L, EQ-5D-5L, SF-6D, and HUI3.
J Mol Med (Berl)
January 2019
Ocular Therapeutics and Drug Delivery, Singapore Eye Research Institute, The Academia, 20 College Road, Singapore, 169856, Singapore.
Valproic acid (VPA) is a histone deacetylase inhibitor used clinically for neurological disorders. It is also potentially useful as anti-fibrotic therapy as it reduced collagen deposition in the post-operative conjunctiva. In this study, we further evaluated the effects of VPA on post-operative inflammation using the mouse model of conjunctival scarring.
View Article and Find Full Text PDFSci Rep
November 2018
Singapore Eye Research Institute, Discovery Tower Level 6 The Academia, 20 College Road, Singapore, 169856, Singapore.
There are no reliable biomarkers to predict thyroid eye disease (TED) in patients with autoimmune thyroid disease (AITD) currently. Several evidences support the involvement of the lacrimal gland in TED. The aim of our study was to quantitatively correlate the changes in tear protein profile with increasing severity of TED.
View Article and Find Full Text PDFNat Commun
November 2018
School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore, 637457, Singapore.
Eye diseases and injuries impose a significant clinical problem worldwide. Safe and effective ocular drug delivery is, however, challenging due to the presence of ocular barriers. Here we report a strategy using an eye patch equipped with an array of detachable microneedles.
View Article and Find Full Text PDFProteomics Clin Appl
January 2019
11 Third Hospital Avenue, 168751, Singapore.
Scope: The purpose of this study is to identify and visualize the spatial distribution of proteins present in amyloid corneal deposits of TGFBI-CD patients using Mass Spectrometry Imaging (MSI) and compare it with healthy control cornea. Corneal Dystrophies (CD) constitute a group of genetically inherited protein aggregation disorders that affects different layers of the cornea. With accumulated protein deposition, the cornea becomes opaque with decreased visual acuity.
View Article and Find Full Text PDFFoot (Edinb)
December 2018
Physical Education and Sports Science Academic Group, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, 637616, Singapore. Electronic address:
Background: While posterior tibial tendon dysfunction (PTTD) commonly presents with flat feet and has been thought to be associated with first ray mobility, many flat-footed individuals are asymptomatic and do not experience any symptoms of PTTD. Thus, there is a need to control for foot type when studying factors related to PTTD. This study aimed to clarify if first ray mobility differed between flat-footed individuals with and without symptoms of PTTD.
View Article and Find Full Text PDFOpen Ophthalmol J
August 2018
Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751, Singapore.
Open Ophthalmol J
July 2018
Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751, Singapore.
Background: LASIK Xtra is a recently described technique which combines LASIK and accelerated corneal cross-linking(CXL) in the same setting. Its long-term outcome in Asians with high myopia is not well described.
Objectives: To compare the efficacy, predictability and safety of LASIK Xtra with LASIK in patients with high myopia.
Sci Rep
August 2018
Ocular Surface Research Group, Singapore Eye Research Institute, Singapore, 168751, Singapore.
Transglutaminase (TG)-2 interacts with matrix proteins and integrins, forming focal adhesions (FA) to initiate cell migration, thus playing a vital role in wound healing. Previously we showed that TG-2 influenced phosphorylation of paxillin and other FA proteins. Here, we aimed to investigate the molecular mechanism of TG-2 regulation of paxillin.
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