6 results match your criteria: "Third Faculty of Medicine and Kralovske Vinohrady University Hospital[Affiliation]"
Personalizing beta-blockade in septic shock: finding the right rhythm and rate for the right patient.
Intensive Care Med
November 2024
Department of Anaesthesiology, Intensive Care, Emergency Medicine, Transfusion Medicine and Pain Therapy, University Hospital of Bielefeld, Bielefeld, Germany.
The Czech Home Parenteral Nutrition Registry REDNUP: Comprehensive Analysis of Adult Patients' Data.
Ann Nutr Metab
June 2024
Internal Department of Third Faculty of Medicine and Královské Vinohrady University Hospital, Charles University Prague, Prague, Czechia.
Introduction: Home parenteral nutrition (HPN) is the primary treatment modality for patients with chronic intestinal failure, one of the least common organ failures. This article provides a retrospective analysis of the data collected on HPN patients in the Czech Republic over the past 30 years.
Methods: National registry data were collected using a standardised online form based on the OASIS registry (Oley - A.
Amiodarone but not propafenone impairs bioenergetics and autophagy of human myocardial cells.
Toxicol Appl Pharmacol
October 2023
Department of Anaesthesia and Intensive Care of The Third Faculty of Medicine and Královské Vinohrady University Hospital, OXYLAB-Laboratory for Mitochondrial Physiology, Charles University, Prague, Czech Republic. Electronic address:
Article Synopsis
- Amiodarone, but not propafenone, causes significant mitochondrial dysfunction in human cardiomyocytes, leading to reduced ATP production and altered cellular metabolism.
- * Prolonged exposure to amiodarone downregulates fatty acid oxidation and increases anaerobic glycolysis, while propafenone shows no adverse effects on cellular bioenergetics.
- * The study indicates that the detrimental impacts of amiodarone on mitochondria are consistent across both human and mouse cardiomyocytes, highlighting potential risks in using this drug at therapeutic doses.
Effect of noradrenaline on propofol-induced mitochondrial dysfunction in human skeletal muscle cells.
Intensive Care Med Exp
November 2022
Department of Anaesthesia and Intensive Care of the Third Faculty of Medicine and Královské Vinohrady University Hospital, OXYLAB-Laboratory for Mitochondrial Physiology, Charles University, Prague, Czech Republic.
Background: Mitochondrial dysfunction is a hallmark of both critical illness and propofol infusion syndrome and its severity seems to be proportional to the doses of noradrenaline, which patients are receiving. We comprehensively studied the effects of noradrenaline on cellular bioenergetics and mitochondrial biology in human skeletal muscle cells with and without propofol-induced mitochondrial dysfunction.
Methods: Human skeletal muscle cells were isolated from vastus lateralis biopsies from patients undergoing elective hip replacement surgery (n = 14) or healthy volunteers (n = 4).
Partial upper sternotomy for aortic valve replacement provides similar mid-term outcomes as the full sternotomy.
J Thorac Dis
April 2022
Department of Cardiac Surgery, Charles University in Prague, Third Faculty of Medicine and Kralovske Vinohrady University Hospital, Prague, Czech Republic.
Background: Minimally invasive aortic valve replacement via upper partial sternotomy (MiniAVR) provides very good short-term results and delivers certain advantages in the postoperative course. There is limited data regarding the mid-term mortality and morbidity following this minimally invasive surgery.
Methods: We provide a retrospective analysis of the patients, undergoing MiniAVR versus full sternotomy (FS) for aortic valve replacement with biological prosthesis.
Demographic data, comorbidities, quality of life, and survival probability of biologic therapy associated with sex-specific differences in psoriasis in the Czech Republic.
Dermatol Ther
March 2021
Department of Dermatovenereology, Charles University, Third Faculty of Medicine and Kralovske Vinohrady University Hospital, Prague, Czech Republic.
BIOREP is a Czech registry of patients with psoriasis undergoing biological treatment. The objective of the study was to compare differences in demographic data, previous therapy, comorbidities, severity of psoriasis, quality of life, drug survival rates, and reasons for discontinuation between men and women. We analyzed a cohort of patients from the registry treated between May 2005 and January 2020.
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