1,491 results match your criteria: "Third Affiliated Hospital of Zhengzhou University[Affiliation]"
Cancer Epidemiol
December 2024
College of Public Health, Zhengzhou University, Zhengzhou, Henan Province 450001, China; Henan Key Laboratory of Tumor Epidemiology and State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan Province 450052, China. Electronic address:
Background: High fasting plasma glucose (HFPG) has been indicated as one of the important risk factors for cancers. This study aimed to estimate the disease burden of cancers attributable to HFPG in China from 1990 to 2021 and predict the burden until 2031.
Methods: The data of cancers attributable to HFPG were extracted from Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 project.
Eur J Nutr
December 2024
Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
Purpose: Recently, a significant negative correlation has been found between vitamin D (VD) and metabolic associated fatty liver disease (MAFLD), suggesting a potential beneficial role of VD in preventing of MAFLD, while underscoring the importance of exploring its mechanisms.
Methods: The experiment comprised two parts: male C57BL/6J mice (6 weeks) were fed a high-fat diet (HFD) and intraperitoneally injected with vitamin D (VD) (1.68 IU/g/week) for 16 weeks.
World J Psychiatry
December 2024
Third Department of Obstetrics and Gynecology, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Background: Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in childhood. There is growing evidence that both preterm birth and maternal education levels substantially affect the likelihood of ADHD in children. However, there are limited systematic reviews and meta-analyses examining these associations.
View Article and Find Full Text PDFJ Ethnopharmacol
December 2024
The Department of Encephalopathy, The First Affiliated Hospital of Henan University of Chinese Medicine, Henan 450000, China; Henan University of Chinese Medicine, Henan 450000, China. Electronic address:
Ethnopharmacological Relevance: Ischemic stroke is an important cause of death and disability worldwide. Xiao-xu-ming Decoction (XXMD) is a classic prescription for the treatment of stroke patients, which has been widely used in China and has significant therapeutic effect, but the therapeutic target and mechanism are still unclear.
Aim Of The Study: The current study aimed to investigate temporal alternation of synaptic damage and the protective effects of XXMD on synaptic damage following cerebral ischemia and reperfusion in vivo.
CNS Neurosci Ther
December 2024
Department of Anesthesiology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.
Background: Esketamine (ESK), a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, modulates neurotransmitter signaling in the central nervous system. However, the specific mechanisms and therapeutic potential of ESK for intracerebral hemorrhage (ICH) remain unclear. This study aimed to investigate whether ESK promotes nerve repair and improves neurological outcomes in an experimental model of ICH.
View Article and Find Full Text PDFFront Med (Lausanne)
November 2024
Zhengzhou Key Laboratory of Gynecological Disease's Early Diagnosis, Zhengzhou, China.
Background: Early natural menopause, characterized by the cessation of ovarian function before the age of 45, has been a subject of prior research indicating that inflammation may predict the onset of menopause. However, the specific relationship between peripheral blood inflammatory parameters and early natural menopause remains ambiguous.
Methods: This observational study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2013-2018.
BMJ Open
December 2024
Health Care Department, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Introduction: HIV can greatly impact the quality of life of pregnant women and may cause adverse pregnancy outcomes, such as preterm birth (PB) and mother-to-child transmission (MTCT). The purpose of this study was to analyse the influencing factors of PB and MTCT in HIV-positive pregnant women.
Methods: HIV-positive pregnant women in Henan Province between January 2016 and December 2022 were selected for the study.
Ecotoxicol Environ Saf
December 2024
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:
Objective: Aluminum (Al) has been proposed as a potential factor influencing fetal growth. However, the existing study findings are inconsistent and there is a lack of population-based epidemiological studies. Our study aimed to evaluate the trimester-specific correlations of Al exposure with fetal development characteristics.
View Article and Find Full Text PDFFront Cell Dev Biol
November 2024
Department of Child Health Care, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Colorectal cancer (CRC) remains one of the most prevalent and fatal malignancies worldwide, consistently ranking among the top three in terms of incidence and mortality. Despite notable advancements in early detection and therapeutic interventions, survival outcomes for advanced-stage CRC are still dismal, largely due to issues such as drug resistance and metastasis. Recent research has increasingly implicated the JAK-STAT signaling pathway as a pivotal contributor to CRC pathogenesis.
View Article and Find Full Text PDFZhonghua Yi Xue Yi Chuan Xue Za Zhi
October 2024
Center for Medical Genetics and Prenatal Diagnosis, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Asian J Surg
December 2024
The Third Affiliated Hospital of Zhengzhou University, Medical Research Center, Henan, Zhengzhou, China; Tianjian Laboratory of Advanced Biomedical Sciences, School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China; Henan Engineering Research Center of Precise Diagnosis and Treatment of Pediatric Glioma, Henan, Zhengzhou, China; Henan International Joint Laboratory of Glioma Metabolism and Microenvironment Research, Zhengzhou, Henan, China; Maternal and Child Neurological Disorders International Joint Research Center, Zhengzhou, Henan, China; Zhengzhou University, Institute of Neuroscience, Zhengzhou, Henan, China; The Third Affiliated Hospital of Zhengzhou University, Department of Neurosurgery, Zhengzhou, Henan, China. Electronic address:
Int J Biol Macromol
December 2024
Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, Henan, China; Department of Hematology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou 450099, Henan, China. Electronic address:
Prediabetes is characterized as a transitional phase between normal blood glucose and diabetes, and the potential role of fucoidan in the progression of diabetes is still debated. The randomized, double-blind, placebo-controlled trial was designed to assess the effect of fucoidan supplementation on glycolipid metabolism, systemic inflammation and gut microbiota in individuals with prediabetes. A total of 70 Chinese participants with prediabetes were randomized to either fucoidan or placebo group, receiving daily doses of 1000 mg fucoidan or placebo capsules for 12 weeks.
View Article and Find Full Text PDFBMC Med Inform Decis Mak
December 2024
School of Computer, Central China Normal University, Wuhan, 430079, China.
Prenatal diagnostics are vital for the woman as well as her unborn baby. The diagnostics help in the early identification of the possibility of complication and the initial measures that help to ameliorate the mother and the fetus health status are taken. Over the year's various techniques have been employed in diagnosing genetic disorders before birth that lack effectiveness in terms of cost, time, and places to access ultra-modern health facilities.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
School of Materials Science and Engineering, Central South University, Changsha 410083, P. R. China.
J Hepatol
November 2024
Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address:
J Neuroinflammation
November 2024
Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, Third Affiliated Hospital and Institute of Neuroscience of Zhengzhou University, Zhengzhou, 450052, China.
Background: T cells have been implicated in various neurological conditions, yet their role in neonatal brain injuries remains unclear. This study aimed to investigate the impact of perinatal factors on frequencies of T cell subsets in preterm infants and to explore the differences in blood genome expression profiles between preterm infants with and without brain injury.
Materials And Methods: Three cohorts of preterm infants were used.
Acad Radiol
November 2024
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China (X.L., X.Z., C.W., L.G.); Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China (X.L., X.Z., C.W., L.G.). Electronic address:
Rationale And Objectives: To develop a radiomics model for non-invasive prediction of colony-stimulating factor 3 (CSF3) expression in ovarian cancer (OC) and evaluate its prognostic value.
Materials And Methods: We acquired clinical data, genetic information, and corresponding computed tomography (CT) scans of OC from The Cancer Genome Atlas and The Cancer Imaging Archive repositories. We assessed the prognostic significance of CSF3 and its association with clinical features through the utilization of Kaplan-Meier analysis, univariate and multivariate Cox regression analysis, along with subgroup analysis.
Front Immunol
November 2024
Department of Urology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China.
Biol Direct
November 2024
Department of Obstetrics and Gynaecology, The Third Affiliated Hospital of Zhengzhou University, No.7 Kangfuqian Street, Erqi District, Zhengzhou, 450052, Henan, China.
Background: Preeclampsia (PE) is a severe pregnancy complication characterized by complex molecular interactions. Understanding these interactions is crucial for developing effective therapeutic strategies.
Methods: This study applies a pharmacometabolomics approach to explore the roles of miR-155 and PKG1 in PE, focusing on the regulatory influence of the NF-κB signaling pathway.
Zhonghua Fu Chan Ke Za Zhi
November 2024
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing100730, China.
Environ Res
January 2025
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:
Sci Rep
November 2024
Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, Institute of Neuroscience, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Neurotoxic effects of general anesthetics, particularly sevoflurane, on pediatric neurodevelopment are a global concern. This study investigated the molecular and metabolic impacts of repeated short exposures to sevoflurane in neonatal rats. Metabolomics analysis revealed significant changes in fatty acid and mitochondrial energy metabolism.
View Article and Find Full Text PDFJ Enzyme Inhib Med Chem
December 2024
Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
In this work, thirty 2,4-diarylaminopyrimidine-based hydrazones were designed, synthesised, and their anti-thyroid cancer activity were explored. The majority of compounds exhibit moderate to excellent cytotoxic activity against FAK overexpressing TPC-1 cells, with IC values ranging from 0.113 to 1.
View Article and Find Full Text PDFMol Ther Methods Clin Dev
December 2024
Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, Institute of Neuroscience and The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
Pediatric monogenetic diseases encompass a spectrum of debilitating neurological disorders that affect infants and children, often resulting in profound cognitive and motor impairments. Gene replacement therapy holds immense promise in addressing the underlying genetic defects responsible for these conditions. Adeno-associated virus (AAV) vectors have emerged as a leading platform for delivering therapeutic genes due to their safety profile and ability to transduce various cell types, including neurons.
View Article and Find Full Text PDFSci Rep
November 2024
Department of Laboratory Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Cardiac biomarkers are being increasingly applied in pediatric populations, including those with cardiogenic and non-cardiogenic myocardial injury disease. The upper reference limits of biomarkers are an important reference for disease diagnosis and health evaluation. However, the upper reference limits of pediatric cardiac biomarkers remains unknown.
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