1 results match your criteria: "Theodor-Boveri-Institute of the University of Wuerzburg[Affiliation]"
Curr Biol
September 2002
Theodor-Boveri-Institute of the University of Wuerzburg, Physiological Chemistry I, Am Hubland, D-97074 Wuerzburg, Germany.
Gridlock (grl) is one of the first mutations characterized from the large zebrafish mutagenesis screens, and it results in an arterial (aortic) maturation defect, which was proposed to resemble aortic coarctation, a clinically important human malformation. While the grl mutation appears to be a hypomorph, grl knockdown experiments have shown even stronger effects on arterial development. We have generated a knockout of the murine Hey2 (gridlock) gene to analyze the mammalian phenotype.
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