Modulating π-bridge in donor-π-acceptor covalent organic frameworks for low-energy-light-driven photocatalytic reaction.

Most of the photocatalytic reactions are currently driven by high-energy light (UV, blue light), which inevitably leads to side reactions and co-catalyst deactivation. Therefore, there is an urgent need to prepare novel photocatalysts with low-energy photocatalytic properties. Herein, we report a rational molecular design of covalent organic frameworks (COFs) equipped with donor-π-acceptor systems with different π-bridges (aromatic ring, mono- and bis-alkynyl).

Perceptions of Patients With Stroke Regarding an Immersive Virtual Reality-Based Exercise System for Upper Limb Rehabilitation: Questionnaire and Interview Study.

Background: With substantial resources allocated to develop virtual reality (VR)-based rehabilitation exercise programs for poststroke motor rehabilitation, it is important to understand how patients with stroke perceive these technology-driven approaches, as their perceptions can determine acceptance and adherence.

Objective: This study aimed to examine the perceptions of patients with stroke regarding an immersive VR-based exercise system developed to deliver shoulder, elbow, forearm, wrist, and reaching exercises.

Methods: A questionnaire was used to assess the perceptions of 21 inpatients who had experienced stroke (mean time from stroke onset: 37.

Psychometric validation of the Cardiac Distress Inventory - Short Form among people with cardiac diseases in Hong Kong.

Objectives: Cardiac patients experience various somatic and psychosocial symptoms and stress is an important prognostic factor of cardiac rehabilitation. This study evaluated the psychometric properties of the 12-item Cardiac Distress Inventory - Short Form (CDI-SF) in the Chinese context.

Methods: A total of 227 patients with cardiac diseases were recruited in a specialist outpatient clinic in Hong Kong between Aug 2022 and July 2023.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

Advanced Management of Complex Transplant Lithiasis: Low Lithotomy and Boot Stirrups Technique.

BACKGROUND Transplant lithiasis may be rare but poses significant risk to the renal graft function of the recipient. Immediate management is necessitated upon first detection, to prevent further complications. CASE REPORT We report 2 cases of transplant lithiasis that were not treated immediately upon first detection.

Zeolite-like algal biochar nanoparticles for enhanced antibiotics removal: Sorption mechanisms and theoretical calculations.

In the study, Sargassum horneri (S. horneri) was used to create a novel zeolite-like algal biochar (KSBC). KSBC with doping of N, O, S, Al, and Si, displayed zeolite-like properties, including well-developed porosity, a high specific surface area (1137.

Rebalancing immune homeostasis in combating disease: The impact of medicine food homology plants and gut microbiome.

Background: Gut microbiota plays an important role in multiple human physiological processes and an imbalance in it, including the species, abundance, and metabolites can lead to diseases. These enteric microorganisms modulate immune homeostasis by presenting a myriad of antigenic determinants and microbial metabolites. Medicinal and food homologous (MFH) plants, edible herbal materials for both medicine and food, are important parts of Traditional Chinese Medicine (TCM).

CO Sequestration Technologies May Undermine China's Sustainable Development Goals through the Climate-Energy-Air-Health Cascade.

CO sequestration technologies (CSTs) allow for increased CO emissions without exceeding a chosen temperature limit by creating additional carbon budgets. While these CO sequestration technologies offer low-cost routes to net-zero emissions, namely, the CST benefits, they impede progress to the Sustainable Development Goals, namely, the CST disbenefits. Focusing on China, we assess both the CST disbenefits and benefits in the climate-energy-air-health cascade by an integrated modeling framework.

Association of Metabolomics With Incidence of Age-Related Macular Degeneration: The UK Biobank Study.

Purpose: The purpose of this study was to identify serum metabolites associated with age-related macular degeneration (AMD) incidence and investigate whether metabolite profiles enhance AMD risk prediction.

Methods: In a prospective cohort study involving 240,317 UK Biobank participants, we assessed the associations of 168 metabolites with AMD incidence using Cox hazards models. Principal component analysis (PCA) captured 90% of the variance in metabolites.

A brief alcohol intervention during smoking cessation treatment in daily cigarette smokers: A pilot randomized controlled trial.

Alcohol use attenuates successful smoking cessation. We examined the feasibility, acceptability, and preliminary efficacy of a brief alcohol intervention in smokers. In this two-arm, assessor-blinded randomized controlled trial, we randomized 100 daily smokers (82.

Aligning knowledge concepts to whole slide images for precise histopathology image analysis.

Due to the large size and lack of fine-grained annotation, Whole Slide Images (WSIs) analysis is commonly approached as a Multiple Instance Learning (MIL) problem. However, previous studies only learn from training data, posing a stark contrast to how human clinicians teach each other and reason about histopathologic entities and factors. Here, we present a novel knowledge concept-based MIL framework, named ConcepPath, to fill this gap.

Balancing economic growth and environmental conservation through the optimization of rail transit routes for sustainable development.

Drawing from the United Nations Sustainable Development Goals (SDGs), this study offers a framework for optimizing rail transit routes, balancing economic benefits with environmental preservation. Using the Bivariate Choropleth-Multi-Criteria Decision Analysis (BC-MCDA) model, we categorize global regions into economic benefit, environmental conservation, high-conflict, and low-conflict zones. Specifically, 7.

Normative values of spinal and peripheral proprioception in position sense among healthy adolescents and young adults.

Establishing normative values and understanding how proprioception varies among body parts is crucial. However, the variability across individuals, especially adolescents, makes it difficult to establish norms. This prevents further investigation into classifying patients with abnormal proprioception.

INSIHGT: an accessible multi-scale, multi-modal 3D spatial biology platform.

Biological systems are complex, encompassing intertwined spatial, molecular and functional features. However, methodological constraints limit the completeness of information that can be extracted. Here, we report the development of INSIHGT, a non-destructive, accessible three-dimensional (3D) spatial biology method utilizing superchaotropes and host-guest chemistry to achieve homogeneous, deep penetration of macromolecular probes up to centimeter scales, providing reliable semi-quantitative signals throughout the tissue volume.

Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction.

The lack of a robust system to reproducibly propagate HRV-C, a family of viruses refractory to cultivation in standard cell lines, has substantially hindered our understanding of this common respiratory pathogen. We sought to develop an organoid-based system to reproducibly propagate HRV-C, and characterize virus-host interaction using respiratory organoids. We demonstrate that airway organoids sustain serial virus passage with the aid of CYT387-mediated immunosuppression, whereas nasal organoids that more closely simulate the upper airway achieve this without any intervention.

Embodied neuromorphic synergy for lighting-robust machine vision to see in extreme bright.

Proper exposure settings are crucial for modern machine vision cameras to accurately convert light into clear images. However, traditional auto-exposure solutions are vulnerable to illumination changes, splitting the continuous acquisition of unsaturated images, which significantly degrades the overall performance of underlying intelligent systems. Here we present the neuromorphic exposure control (NEC) system.

Multi-Functional Bio-HJzyme Engineered Polyetheretherketone Implant with Cascade-Amplification Therapeutic Capabilities Toward Intractable Implant-Associated Infections.

Intractable implant-associated infections (IAIs) are the primary cause of prosthetic implant failure, particularly in the context of diabetes mellitus. There is an urgent need to design and construct versatile engineered implants integrated with cascade amplification therapeutic modality to significantly improve the treatment of diabetic IAIs. To address this issue, a multi-functional MXene/AgPO@glucose oxidase bio-heterojunction enzyme (M/A@GOx bio-HJzyme) coating is developed, which is decorated with an inert sulfonated polyetheretherketone implant (SP-M/A@G) via hydrothermal treatment and layered deposition.

Identifying brain targets for real-time fMRI neurofeedback in chronic pain: insights from functional neurosurgery.

Background: The lack of clearly defined neuromodulation targets has contributed to the inconsistent results of real-time fMRI-based neurofeedback (rt-fMRI-NF) for the treatment of chronic pain. Functional neurosurgery (funcSurg) approaches have shown more consistent effects in reducing pain in patients with severe chronic pain.

Objective: This study aims to redefine rt-fMRI-NF targets for chronic pain management informed by funcSurg studies.

Lighting Up and Identifying Metal-Binding Proteins in Cells.

Metal ions, either essential or therapeutic, play critical roles in life processes or in the treatment of diseases. Proteins and enzymes are involved in metal homeostasis and the action of metallodrugs. Imaging and identifying these metal-binding proteins will facilitate the elucidation of metal-mediated life processes.

Case Report: The unrelenting journey-successful resolution of catecholaminergic polymorphic ventricular tachycardia (CPVT) through right cardiac sympathetic denervation in a teenager after left cardiac sympathetic denervation.

Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmia disorder characterized by ventricular arrhythmia triggered by adrenergic stimulation.

Case Presentation: A 9-year-old boy presented with convulsions following physical exertion. Bidirectional ventricular tachycardia (VT) during a treadmill test led to the diagnosis of catecholaminergic polymorphic ventricular tachycardia (CPVT).

Role of species in pathogenesis, immune regulation, and prognostic tools for managing ulcerative colitis and Crohn's disease.

The gut microbiome plays a key role in the pathogenesis and disease activity of inflammatory bowel disease (IBD). While research has focused on the bacterial microbiome, recent studies have shifted towards host genetics and host-fungal interactions. The mycobiota is a vital component of the gastrointestinal microbial community and plays a significant role in immune regulation.

3D Bioprinting of Graphene Oxide-Incorporated Hydrogels for Neural Tissue Regeneration.

Bioprinting has emerged as a powerful manufacturing platform for tissue engineering, enabling the fabrication of 3D living structures by assembling living cells, biological molecules, and biomaterials into these structures. Among various biomaterials, hydrogels have been increasingly used in developing bioinks suitable for 3D bioprinting for diverse human body tissues and organs. In particular, hydrogel blends combining gelatin and gelatin methacryloyl (GelMA; "GG hydrogels") receive significant attention for 3D bioprinting owing to their many advantages, such as excellent biocompatibility, biodegradability, intrinsic bioactive groups, and polymer networks that combine the thermoresponsive gelation feature of gelatin and chemically crosslinkable attribute of GelMA.

Enhancing bone regeneration through 3D printed biphasic calcium phosphate scaffolds featuring graded pore sizes.

Human long bones exhibit pore size gradients with small pores in the exterior cortical bone and large pores in the interior cancellous bone. However, most current bone tissue engineering (BTE) scaffolds only have homogeneous porous structures that do not resemble the graded architectures of natural bones. Pore-size graded (PSG) scaffolds are attractive for BTE since they can provide biomimicking porous structures that may lead to enhanced bone tissue regeneration.