4D bioprinting of transformable living constructs with sustained local growth factor presentation for advanced tissue engineering applications.

Traditional tissue engineering strategies focus on geometrically static tissue scaffolds, lacking the dynamic capability found in native tissues. The emerging field of 4D bioprinting offers a promising method to address this challenge. However, the requirement for consistent exogenous supplementation of growth factors (GFs) during tissue maturation poses a significant obstacle for in vivo application of 4D bioprinted constructs.

Prediction Models of Medication Adherence in Chronic Disease Patients: Systematic Review and Critical Appraisal.

Aims And Objectives: To summarise the currently developed risk prediction models for medication adherence in patients with chronic diseases and evaluate their performance and applicability.

Background: Ensuring medication adherence is crucial in effectively managing chronic diseases. Although numerous studies have endeavoured to construct risk prediction models for predicting medication adherence in patients with chronic illnesses, the reliability and practicality of these models remain uncertain.

Retracted: Ingenol-3-Angelate Suppresses Growth of Melanoma Cells and Skin Tumor Development by Downregulation of NF-κB-Cox2 Signaling.

This publication has been retracted by the Editor due to the identification of non-original figure images and manuscript content that raise concerns regarding the credibility and originality of the study and the manuscript.Reference:Dunwei Wang, Pengcheng Liu. Ingenol-3-Angelate Suppresses Growth of Melanoma Cells and Skin Tumor Development by Downregulation of NF-kB-Cox2 Signaling.

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of colorectal cancer, 2024 update.

The 2024 updates of the Chinese Society of Clinical Oncology (CSCO) Clinical Guidelines for the diagnosis and treatment of colorectal cancer emphasize standardizing cancer treatment in China, highlighting the latest advancements in evidence-based medicine, healthcare resource access, and precision medicine in oncology. These updates address disparities in epidemiological trends, clinicopathological characteristics, tumor biology, treatment approaches, and drug selection for colorectal cancer patients across diverse regions and backgrounds. Key revisions include adjustments to evidence levels for intensive treatment strategies, updates to regimens for deficient mismatch repair (dMMR)/ microsatellite instability-high (MSI-H) patients, proficient mismatch repair (pMMR)/ microsatellite stability (MSS) patients who have failed standard therapies, and rectal cancer patients with low recurrence risk.

Plasma fibrinogen as a potential biomarker of cognitive impairment after acute ischemic stroke.

Fibrinogen (FBG) has been discovered to be associated with cognitive impairment (CI) and dementia. However, the exact correlation between FBG levels and CI after acute ischemic stroke (AIS) remains uncertain. Plasma FBG levels were measured in 398 patients with AIS who underwent comprehensive neuropsychological evaluation.

True-bone-ceramics / type I collagen scaffolds for repairing osteochondral defect.

In recent years, the incidence of cartilage defects has increased dramatically, and its etiology is complex and varied. Osteochondritis dissecans (OCD), as one of the main etiologies, damages both cartilage and bone tissues and can progress to severe osteoarthritis, which has been one of the difficult problems for clinicians. The vigorous development of material science and tissue engineering provides new ideas for the treatment of OCD, in which the selection of scaffold materials is particularly important.

The role of fecal microbiota transplantation in type 2 diabetes mellitus treatment.

In contemporary microbial research, the exploration of interactions between microorganisms and multicellular hosts constitutes a burgeoning field. The gut microbiota is increasingly acknowledged as a pivotal contributor to various disorders within the endocrine system, encompassing conditions such as diabetes and thyroid diseases. A surge in research activities has been witnessed in recent years, elucidating the intricate interplay between the gut microbiota and disorders of the endocrine system.

Application of autophagy in mesenchymal stem cells.

In this editorial, we have taken an in-depth look at the article published by Wan . The study showed that preconditioning mesenchymal stem cells (MSCs) protected them against programmed cell death, and increased their survival rate and therapeutic potential. Autophagy, a type of programmed cell death, is a major intracellular degradation and recycling pathway that is crucial for maintaining cellular homeostasis, self-renewal, and pluripotency.

Obesity-Surgery is not the end.

In this editorial we comment on the article published in the recent issue of the . It investigates the potential mechanism of alcohol use disorder (AUD) following weight loss and its future prospects. We are particularly interested in this issue.

Landscape of transarterial chemoembolization represented interventional therapy for hepatocellular carcinoma.

This article discusses the article written by Tan . Transarterial chemoembolization (TACE) is one of the main treatment methods for advanced hepatocellular carcinoma (HCC). There are other vascular interventional therapies, including drug-eluting bead TACE, transarterial radioembolization, and hepatic arterial infusion chemotherapy.

3D-printed TiC/polycaprolactone composite scaffold with a DOPA-SDF1 surface modified for bone repair.

Large bone defects are a major clinical challenge in bone reconstructive surgery. 3D printing is a powerful technology that enables the manufacture of custom tissue-engineered scaffolds for bone regeneration. Electrical stimulation (ES) is a treatment method for external bone defects that compensates for damaged internal electrical signals and stimulates cell proliferation and differentiation.

Sesamol hinders the proliferation of intracellular bacteria by promoting fatty acid metabolism and decreasing excessive inflammation.

The extraintestinal pathogenic Escherichia coli (ExPEC) is a significant zoonotic bacterial pathogen that can cause severe infections and potentially cross-transmit between different hosts. The treatment of clinical bacterial infections is challenging because of the increasingly severe problem of drug resistance. The development of new strategies for managing bacterial infections is essential.

The relationship between life's essential 8 score and depression symptom severity: evidence from a nationally representative sample of U.S. adults.

Background: Many studies have indicated that adverse cardiovascular health (CVH) behaviors are associated with an elevated risk of depression. However, the dose-response relationship between the two and the relative contributions of individual CVH components to depression risk remain unclear.

Methods: We utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2015 and 2018.

Association between life's essential 8 and periodontitis in U.S. adults.

Periodontitis is closely related to lifestyle habits. Our objective was to examine the relationship between the Life's Essential 8 (LE8) and the prevalence of periodontitis in American adults. This study used data from the 2009-2014 National Health and Nutrition Examination Survey (NHANES).

Self-efficacy and healthy lifestyle behaviors as mediators between COVID-19 care knowledge and health status.

The COVID-19 epidemic has affected the psychological well-being and daily life of college students, leading to a decrease in their quality of life. Health status can be influenced by a variety of factors. This study aims to assess the current health status of university students and explore the relationships among COVID-19 care knowledge, self-efficacy, healthy lifestyle behaviors, and health status and how these factors are influenced.

Automatic calculation method for stenosis ratio based on dialysis access ultrasound image segmentation.

Background: Dialysis Access (DA) stenosis impacts hemodialysis efficiency and patient health, necessitating exams for early lesion detection. Ultrasound is widely used due to its non-invasive, cost-effective nature. Assessing all patients in large hemodialysis facilities strains resources and relies on operator expertise.

Global, regional, and national trends in gastric cancer burden: 1990-2021 and projections to 2040.

Background: Gastric cancer (GC) is a common malignancy of the digestive system, with significant geographical variation in its disease burden.

Methods: This study used data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to analyze three key indicators: incidence, mortality, and disability-adjusted life years (DALYs). Initially, a detailed analysis of the GC burden was conducted from global, regional, national, gender, and age perspectives.

Gallstones, cholecystectomy, and cancer risk: an observational and Mendelian randomization study.

This study aimed to comprehensively examine the association of gallstones, cholecystectomy, and cancer risk. Multivariable logistic regressions were performed to estimate the observational associations of gallstones and cholecystectomy with cancer risk, using data from a nationwide cohort involving 239 799 participants. General and gender-specific two-sample Mendelian randomization (MR) analysis was further conducted to assess the causalities of the observed associations.

Non-antibiotic dependent photothermal antibacterial hemostatic MXene hydrogel for infectious wounds healing.

On account of the existence of antibiotic resistance, the wound healing of pathogenic infection is still a challenge in modern society. A desirable wound dressing should own the abilities of adhesiveness, hemostasis and good mechanical property, meanwhile the property of eliminating bacteria without side effects is also highly needed. In this work, we established a kind of hydrogel based on carboxymethyl cellulose-graft-tyramine (CMC-Ty) and MXene (TiCT) through employing HO/HRP (horseradish peroxidase) as the initiator, then the as-prepared hydrogel (named CMC-Ty/MXene) was immersed in tannic acid (TA) solution, and this TA-treated hydrogel was called CMC-Ty/MXene+TA.

The association between triglyceride-glucose index and neutrophil-lymphocyte ratio and all-cause mortality in the general US population: NHANES 2001-2018.

Background: The association between the triglyceride-glucose (TyG) index and mortality in the general population remains controversial, with inconsistent findings across studies.

Objective: This study aims to investigate the relationship between the TyG index and mortality in the U.S.

Adverse events in patients with castration-resistant prostate cancer treated with ra-223: a retrospective pharmacovigilance study.

Background: Radium-223 (Ra-223) received U.S. Food and Drug Administration (FDA) approval for treating castration-resistant prostate cancer with symptomatic bone metastases, excluding visceral metastases.

Preparation and Characterization of C-Reactive Protein Dual-Particle Latex-Enhanced Immunoturbidimetric Reagents.

This study aims to couple C-reactive protein (CRP) antibodies onto latex spheres of 2 different sizes to enhance the accuracy and sensitivity of CRP detection. Furthermore, it seeks to establish a robust methodological framework crucial for advancing the development of latex-enhanced immunoturbidimetric detection reagents. CRP, an acute-phase protein, rapidly elevates in response to infections or tissue damage.

Stable and Lead-Free Perovskite Hemispherical Photodetector for Vivid Fourier Imaging.

The filterless single-pixel imaging technology is anticipated to hold tremendous competitiveness in diverse imaging applications. Nevertheless, achieving single-pixel color imaging without a filter remains a formidable challenge. Here a lead-free perovskite hemispherical photodetector is reported for filterless single-pixel color imaging.

Epidemiology, risk factors and mechanism of breast cancer and atrial fibrillation.

Cancer and cardiovascular diseases are leading causes of death worldwide. Among them, breast cancer is one of the most common malignancies in women, while atrial fibrillation is one of the most extensively studied arrhythmias, with significant public health implications. As the global population ages and advancements in cancer treatments continue, the survival rates of breast cancer patients have significantly improved, leading to an increasing coexistence of breast cancer and atrial fibrillation.