7 results match your criteria: "The Zhangjiagang Affiliated Hospital of Soochow University[Affiliation]"
Deciphering the role of SAMHD1 in endometrial cancer progression.
Biol Direct
October 2024
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, No. 1055, Sanxiang Road, Suzhou, Jiangsu Province, 215000, China.
Article Synopsis
- Endometrial cancer (EC) poses challenges due to its varied nature and complicated biology, with SAMHD1 being a key protein that may influence its progression.
- The study investigates how SAMHD1 interacts with TRIM27 and PTEN, revealing that SAMHD1 affects the process of PTEN ubiquitination, which is vital to understanding EC development.
- The findings suggest that targeting the interaction between SAMHD1, TRIM27, and PTEN could lead to new therapeutic strategies for treating endometrial cancer.
OPCML Methylation and the Risk of Ovarian Cancer: A Meta and Bioinformatics Analysis.
Front Cell Dev Biol
March 2021
Nanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, China.
Article Synopsis
- - The study investigates the relationship between the methylation of the OPCML gene and the risk of ovarian cancer, analyzing data from various databases and a total of 476 ovarian cancer patients and 385 controls.
- - Results indicated a significant association between OPCML methylation and ovarian cancer risk, with a pooled odds ratio of 33.47, and this association was consistent across different subgroups.
- - While three specific CpG sites showed higher methylation levels in cancer tissues, there were no significant links found between OPCML methylation and clinicopathological parameters or overall survival according to TCGA data.
Association of maternal folate intake during pregnancy with infant asthma risk.
Sci Rep
June 2019
The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China.
Several studies assessed the association of maternal folate intake with infant asthma risk, but the findings are controversial. We performed a meta-analysis to clarify the association between maternal folate intake and infant asthma risk. PubMed and SCOPUS databases were searched for related studies published until August 2018.
View Article and Find Full Text PDFNeonatal Maternal Deprivation Followed by Adult Stress Enhances Adrenergic Signaling to Advance Visceral Hypersensitivity.
Neurosci Bull
February 2019
Laboratory for Translational Pain Medicine, Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
The pathophysiology of visceral pain in patients with irritable bowel syndrome remains largely unknown. Our previous study showed that neonatal maternal deprivation (NMD) does not induce visceral hypersensitivity at the age of 6 weeks in rats. The aim of this study was to determine whether NMD followed by adult stress at the age of 6 weeks induces visceral pain in rats and to investigate the roles of adrenergic signaling in visceral pain.
View Article and Find Full Text PDFReactive oxygen species downregulate ARID1A expression via its promoter methylation during the pathogenesis of endometriosis.
Eur Rev Med Pharmacol Sci
October 2017
Department of Gynecology, Zhangjiagang First People's Hospital, The Zhangjiagang Affiliated Hospital of Soochow University, Zhangjiagang, China.
Objective: Oxidative stress caused by reactive oxygen species (ROS) plays an important role in the pathogenesis of endometriosis. The gene AT-rich interactive domain 1A (ARID1A), is frequently down regulated and inactivated in endometriosis. This report is focused on the molecular mechanism of the correlation between oxidative stress and ARID1A gene expression in endometrial cell oxidative damage model.
View Article and Find Full Text PDFUpregulation of LncRNA PANDAR predicts poor prognosis and promotes cell proliferation in cervical cancer.
Eur Rev Med Pharmacol Sci
October 2017
Department of Obstetrics and Gynecology, Zhangjiagang First People's Hospital, The Zhangjiagang Affiliated Hospital of Soochow University, Zhangjiagang, China.
Objective: To investigate the expression level of long non-coding RNA promoter of CDKN1A antisense DNA damage activated RNA (lncRNA PANDAR) in cervical cancer and to analyze the effects of PANDAR on biological behaviors of cervical cancer and the clinical significance of PANDAR.
Patients And Methods: A total of 68 pairs of cervical cancer and paired cancer-adjacent tissue specimens were collected. The relative expression of PANDAR in tissues was detected by quantitative Real-time polymerase chain reaction (qRT-PCR) so as to analyze the relationship between PANDAR and clinicopathological factors of cervical cancer and evaluate its clinical significance.
Research on the correlation between MMP gene polymorphism and susceptibility to cervical cancer in Chinese women.
Panminerva Med
October 2017
Department of Obstetrics and Gynecology, Zhangjiagang First People's Hospital, Zhangjiagang, China.