165 results match your criteria: "The Zabludowicz Center for Autoimmune Diseases[Affiliation]"

Article Synopsis
  • The study investigates the pregnancy outcomes of women with antiphospholipid syndrome (APS) and antiphospholipid antibodies (aPL) who have had five or more pregnancies (grand multiparity) and compares them to two control groups: those with fewer pregnancies and those without aPL/APS.
  • Results showed that while most pregnancy-related parameters were similar across the groups, grand multiparity women with aPL/APS had higher rates of obstetric APS diagnosis, older maternal age, higher body mass index (BMI), more cases of polyhydramnios, and delivered larger babies.
  • The conclusions suggest that the perinatal outcomes for grand multiparity women with aPL/APS are not worse than those of their counterparts
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Alpha-1 antagonist treatment for eyelid retraction in patients with thyroid eye disease-a prospective pilot study.

Eye (Lond)

January 2025

The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel, Affiliated to the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Sympathetic overstimulation of Müller's muscle is a suggested mechanism underlying upper eyelid retraction in thyroid eye disease (TED). We examined the effect of tamsulosin, an alpha-1 antagonist, on eyelid retraction in patients with TED.

Methods: A single-centre prospective study.

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Vitamin K Antagonist Anticoagulation in Antiphospholipid Syndrome: Time in Therapeutic Range and Clinical Outcomes.

Am J Med

October 2024

School of Medicine, Faculty of Medicine and Health Sciences, Tel Aviv University, Israel; Hematology Institute and Blood Bank, Meir Medical Center, Kfar Saba, Israel. Electronic address:

Article Synopsis
  • Antiphospholipid syndrome patients often receive vitamin K antagonists, but only 29.9% achieve an optimal therapeutic range (INR ≥ 70%), which is linked to better outcomes.* -
  • Those with three or more comorbidities are significantly less likely to reach this therapeutic range (9.1%) compared to those with fewer comorbidities (40%).* -
  • Patients maintaining an INR ≥ 70% experience fewer recurrent thrombotic events, particularly arterial ones, highlighting the need for close monitoring in this population.*
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Gut luminal dysbiosis and pathobiosis result in compositional and biodiversified alterations in the microbial and host co-metabolites. The primary mechanism of bacterial evolution is horizontal gene transfer (HGT), and the acquisition of new traits can be achieved through the exchange of mobile genetic elements (MGEs). Introducing genetically engineered microbes (GEMs) might break the harmonized balance in the intestinal compartment.

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HLA-DQ2/8 and COVID-19 in Celiac Disease: Boon or Bane.

Microorganisms

December 2023

Immunosciences Lab., Inc., Los Angeles, CA 90035, USA.

The SARS-CoV-2 pandemic continues to pose a global threat. While its virulence has subsided, it has persisted due to the continual emergence of new mutations. Although many high-risk conditions related to COVID-19 have been identified, the understanding of protective factors remains limited.

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Purpose: To assess factors associated with failure of intravenous methylprednisolone (IVMP) monotherapy as the first-line treatment for thyroid eye disease (TED) and to identify patients who might benefit from supplementing mycophenolate mofetil (MMF) to IVMP.

Methods: Data for all patients with TED treated with IVMP according to the EUGOGO protocol in our center between 2016-2021 were retrospectively analysed.

Results: Forty-seven patients (mean age 51.

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Heart valve disease in primary antiphospholipid syndrome.

Rheumatology (Oxford)

May 2024

Clinical Immunology, Angioedema and Allergy Institute, The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel.

Objectives: APS-associated heart valve disease (HVD) is well described. Nonetheless, limited data exist on clinical parameters associated with the course of primary APS (pAPS) patients with HVD. The goal of this study was to assess clinical features and related outcomes in patients with APS-associated HVD.

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Objectives: Systemic lupus erythematosus (SLE) is associated with an increased cardiovascular risk. Several traditional and disease-specific risk factors have been shown to correlate with the occurrence of cardiovascular events (CVE) in patients with SLE. However, results of previous studies are diverse.

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Objectives: To assess valve surgery outcomes in antiphospholipid syndrome (APS).

Methods: A retrospective study assessing complications and mortality rate and possible factors associated with adverse outcomes of APS patients undergoing valve surgery in two tertiary medical centers.

Results: Twenty-six APS patients (median age at surgery 47.

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Article Synopsis
  • - The approval of COVID-19 vaccines marked a significant advancement in the fight against the pandemic, leading to reduced mortality and severity of the disease with mostly mild side effects reported.
  • - Although rare, there have been some cases of autoimmune conditions, including flare-ups and new occurrences, linked to COVID-19 vaccines.
  • - The text details a specific case of a healthy 49-year-old man who developed Susac vasculitis, a rare autoimmune disease, just five days after receiving the BNT162b2 COVID-19 vaccine.
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Objectives: The BNT162b2 mRNA COVID-19 vaccine has been found to be highly effective in preventing COVID-19 but is associated with increased reactogenicity. We aimed to examine the correlation between immunogenicity and reactogenicity of the BNT162b2 vaccine. Methods: Subjects without prior SARS-CoV-2 infection that participated in active surveillance after being vaccinated with the BNT162b2 vaccine were included.

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Long Term Follow up of Patients With Primary Obstetric Antiphospholipid Syndrome.

Front Pharmacol

April 2022

Clinical Immunology, Angioedema and Allergy Unit, The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.

Primary obstetric antiphospholipid syndrome (OAPS) is defined by specific morbidities and/or losses of pregnancy in the presence of persistent antiphospholipid antibodies (aPL). This variant of APS is usually treated during pregnancy and the post-partum period. Data on occurrence of thrombotic event during long term follow-up of OAPS patients is limited.

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Patterns of Recurrent Thrombosis in Primary Antiphospholipid Syndrome-Multicenter, Real-Life Long-Term Follow-Up.

Front Immunol

May 2022

Clinical Immunology, Angioedema and Allergy Unit, The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Ramat Gan, Israel.

Background: Antiphospholipid syndrome (APS) is an acquired hypercoagulable condition associated with antiphospholipid antibody (aPL) presence. Data on re-thrombosis following APS-diagnosis are limited.

Methods: This is a retrospective analysis of new thrombotic events among primary APS (pAPS) patients followed for up to 15 years in three medical centers in Israel.

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A third dose of the BNT162b2 mRNA vaccine significantly improves immune responses among liver transplant recipients.

J Hepatol

September 2022

Liver Diseases Center, Sheba Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Background & Aims: Immune responses of solid organ transplant recipients to 2 doses of the BNT162b2 mRNA anti-SARS-CoV-2 vaccine are impaired. The immunogenicity and safety of a third dose among liver transplant (LT) recipients are unknown. This work aimed to evaluate the immune response of LT recipients to a third dose of the BNT162b2 mRNA vaccine.

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Sexual dimorphism in COVID-19: potential clinical and public health implications.

Lancet Diabetes Endocrinol

March 2022

Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Department of Diabetes, School of Life Course Science and Medicine, King's College London, London, UK. Electronic address:

Current evidence suggests that severity and mortality of COVID-19 is higher in men than in women, whereas women might be at increased risk of COVID-19 reinfection and development of long COVID. Differences between sexes have been observed in other infectious diseases and in the response to vaccines. Sex-specific expression patterns of proteins mediating virus binding and entry, and divergent reactions of the immune and endocrine system, in particular the hypothalamic-pituitary-adrenal axis, in response to acute stress might explain the higher severity of COVID-19 in men.

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The coronavirus disease-19 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenged globally with its morbidity and mortality. A small percentage of affected patients (20%) progress into the second stage of the disease clinically presenting with severe or fatal involvement of lung, heart and vascular system, all contributing to multiple-organ failure. The so-called 'cytokines storm' is considered the pathogenic basis of severe disease and it is a target for treatment with corticosteroids, immunotherapies and intravenous immunoglobulin (IVIg).

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Chronic thromboembolic pulmonary hypertension in patients with antiphospholipid syndrome: Risk factors and management.

J Heart Lung Transplant

February 2022

Clinical Immunology, Angioedema and Allergy Unit, The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel. Electronic address:

Background: Antiphospholipid syndrome (APS) may cause chronic thromboembolic pulmonary hypertension (CTEPH). Current knowledge regarding prevalence and risk factors for CTEPH among APS patients is limited. We sought to determine clinical features and biomarkers that could identify APS subjects suffering from CTEPH, and describe the prevalence, course and treatment outcomes of patients with APS-CTEPH.

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Background: Diagnostic decision support systems (DDSS) are computer programs aimed to improve health care by supporting clinicians in the process of diagnostic decision-making. Previous studies on DDSS demonstrated their ability to enhance clinicians' diagnostic skills, prevent diagnostic errors, and reduce hospitalization costs. Despite the potential benefits, their utilization in clinical practice is limited, emphasizing the need for new and improved products.

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Article Synopsis
  • The study investigates how body mass index (BMI) affects the retention of TNF-α blockers in patients with rheumatoid arthritis (RA).
  • It analyzes data from 521 RA patients who started TNF blockers between 2011 and 2019, categorizing them by BMI and assessing treatment effectiveness based on cessation due to inefficacy.
  • Findings indicate that morbidly obese patients are significantly more likely to discontinue treatment compared to those with normal weight, suggesting a need for tailored approaches in this subgroup.
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The Incidence and Predictors of Solid- and Hematological Malignancies in Patients with Giant Cell Arteritis: A Large Real-World Database Study.

Int J Environ Res Public Health

July 2021

Department of Medicine 'B', The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Ramat Gan 5265601, Israel.

Background: The association between giant cell arteritis (GCA) and malignancies had been widely investigated with studies reporting conflicting results. Therefore, in this study, we aimed to investigate this association using a large nationwide electronic database.

Methods: This study was designed as a retrospective cohort study including GCA patients first diagnosed between 2002-2017 and age, sex and enrollment time-matched controls.

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Background: Familial Mediterranean Fever (FMF) is an autosomal recessive autoinflammatory disease associated with various systemic comorbidities. Recent research regarding the association with depression and anxiety has yielded conflicting results. The current study aims were to examine whether such an association exists using big data analysis methodology.

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Ethnicity and Antiphospholipid Syndrome in Israel.

Arthritis Care Res (Hoboken)

November 2022

The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: Antiphospholipid syndrome (APS) is an acquired coagulopathy associated with the presence of antiphospholipid antibodies. Whether ethnicity modulates APS clinical course is not known. The aim of our study was to assess the interplay of ethnicity and APS in Israel.

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Familial Mediterranean fever (FMF)-response to TNF-blockers used for treatment of FMF patients with concurrent inflammatory diseases.

Joint Bone Spine

October 2021

Heller Institute of Medical Research, The Chaim Sheba Medical Center, Tel Hashomer, Israel; Rheumatology Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel; Department of Medicine F, The Chaim Sheba Medical Center, Tel Hashomer, Israel; The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Objective: Familial Mediterranean fever (FMF) is the most common interleukin 1 (IL-1)-driven monogenic autoinflammatory disease. Yet published data also suggest that tumor necrosis factor (TNF) may have a role in the pathogenesis of FMF and may serve as a target for treatment. In the present study we evaluate this hypothesis.

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The management of reproductive issues in women with inflammatory arthritis has greatly changed over decades. In the 1980-1990s, women with refractory forms of arthritis were either not able to get pregnant or did choose not to get pregnant because of their disabling disease. Hence, the traditional belief that pregnancy can induce a remission of arthritis.

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