4 results match your criteria: "The Wellcome Trust Sanger Institute (WTSI)[Affiliation]"
Functional analysis of colonization factor antigen I positive enterotoxigenic identifies genes implicated in survival in water and host colonization.
Microb Genom
June 2021
Department of Medicine, University of Cambridge, Cambridge, UK.
Enterotoxigenic (ETEC) expressing the colonization pili CFA/I are common causes of diarrhoeal infections in humans. Here, we use a combination of transposon mutagenesis and transcriptomic analysis to identify genes and pathways that contribute to ETEC persistence in water environments and colonization of a mammalian host. ETEC persisting in water exhibit a distinct RNA expression profile from those growing in richer media.
View Article and Find Full Text PDFGenomic and Phenotypic Analyses Reveal the Emergence of an Atypical Salmonella enterica Serovar Senftenberg Variant in China.
J Clin Microbiol
August 2016
Shenzhen Centre for Disease Control and Prevention, Shenzhen, Guangdong Province, China
Human infections with Salmonella enterica subspecies enterica serovar Senftenberg are often associated with exposure to poultry flocks, farm environments, or contaminated food. The recent emergence of multidrug-resistant isolates has raised public health concerns. In this study, comparative genomics and phenotypic analysis were used to characterize 14 Salmonella Senftenberg clinical isolates recovered from multiple outbreaks in Shenzhen and Shanghai, China, between 2002 and 2011.
View Article and Find Full Text PDFThe population structure of Vibrio cholerae from the Chandigarh Region of Northern India.
PLoS Negl Trop Dis
July 2014
Pathogen Genomics Laboratory, Computational Bioscience Research Center, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
Background: Cholera infection continues to be a threat to global public health. The current cholera pandemic associated with Vibrio cholerae El Tor has now been ongoing for over half a century.
Methodology/principal Findings: Thirty-eight V.
Article Synopsis
- The Wellcome Trust Case Control Consortium 3 conducted a genome-wide association scan for anorexia nervosa using 2,907 cases from 15 European populations and the Illumina 670K chip.
- The study compared different methods to identify population stratification, suggesting that using all SNPs with a minor allele frequency (MAF) greater than 1% could be more effective than the usual threshold of 5%.
- Principal component analysis revealed significant genetic variation across the populations, helping to identify hidden stratification and offering insights for better designing and interpreting association studies in international research efforts.