Wound closure and wound management: A new therapeutic molecular target.

Wound closure and infection control are the primary goal of wound management. A variety of disinfectants and antimicrobial agents are widely available today and routinely achieve infection control. On the contrary, wound closure still remains a challenging goal.

Enhancement of osteoblast adhesion to UV-photofunctionalized titanium via an electrostatic mechanism.

The mechanism underlying the recently found photofunctionalization of titanium is unknown. We focused on how the initial interaction between the cells and photofunctionalized titanium is enhanced at a molecular-level and the role played by the electrostatic status of the titanium surfaces in the possible regulatory mechanism for determining their bioactivity. Rat bone marrow-derived osteoblasts were cultured on untreated and ultraviolet (UV)-treated titanium surfaces.

Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure.

Wounds created in the oral cavity heal rapidly and leave minimal scarring. We have examined a role of a previously isolated cDNA from oral wounds encoding wound inducible transcript-3.0 (wit3.

Time-dependent degradation of titanium osteoconductivity: an implication of biological aging of implant materials.

The shelf life of implantable materials has rarely been addressed. We determined whether osteoconductivity of titanium is stable over time. Rat bone marrow-derived osteoblasts were cultured on new titanium disks (immediately after acid-etching), 3-day-old (stored after acid-etching for 3 days in dark ambient conditions), 2-week-old, and 4-week-old disks.

Vitamin D and bone physiology: demonstration of vitamin D deficiency in an implant osseointegration rat model.

Purpose: The patient population varies in nutritional deficiencies, which may confound the host response to biomaterials. The objective of this study was to evaluate the effect of a common deficiency of vitamin D on implant osseointegration in the rat model.

Materials And Methods: Male Sprague-Dawley rats were maintained under the cessation of vitamin D intake and UV exposure.

Trabecular bone deterioration in col9a1+/- mice associated with enlarged osteoclasts adhered to collagen IX-deficient bone.

Introduction: Short collagen IX, the exclusive isoform expressed by osteoblasts, is synthesized through alternative transcription of the col9a1 gene. The function of short collagen IX in bone was characterized in col9a1-null mutant mice.

Materials And Methods: Trabecular bone morphometry of lumbar bones and tibias was evaluated by muCT and nondecalcified histology.

Prosthodontic treatment of patients with hypodontia.

Hypodontia is a relatively rare occurrence that can have a significant impact on treatment planning for those patients with the condition. This paper will describe the forms of hypodontia, as well as associated dental issues. Treatment planning considerations for children, adolescents, and adults will be presented.

Glycosaminoglycan degradation reduces mineralized tissue-titanium interfacial strength.

Although the localization of the proteoglycan/glycosaminoglycan (GAG) complex at the bone-titanium implant interface has been implied, the role of proteoglycans on the establishment of bone-titanium integration is unknown. The hypothesis to be tested was that proteoglycans play an important role in establishing bone-titanium interfacial adhesion. The objective of this study is to investigate the effect of proteoglycan knockdown by GAG enzymatic degradation on the interfacial strength between mineralized tissue and titanium having different surface topographies.

Impact of Human Genome Project on treatment of frail and edentulous patients.

Objective: Because of ongoing increases in life expectancy and deferment of edentulousness to older age, dentists are facing a different challenge to satisfy elderly denture wearers with a higher prevalence of chronic diseases. This discussion introduces the Human Genome databases as novel and powerful resources to re-examine the core problems experienced by frail and edentulous patients.

Background: Recent studies demonstrated that mandibular implant overdentures do not necessarily increase masticatory function, perception and satisfaction in denture wearers with adequate edentulous residual ridges.