3,539 results match your criteria: "The Warren Alpert Medical School of Brown University[Affiliation]"

Objective: This review aims to formulate the most current, evidence-based recommendations regarding complication avoidance, rehabilitation, pain therapy and palliative care for patients with metastatic spine tumors.

Methods: A systematic literature search in PubMed and MEDLINE, and was performed from 2013 to 2023 using the search terms "complications" + "spine metastases", "spine metastases" + + "rehabilitation", "spine metastases" + "pain therapy" + "palliative care". Screening criteria resulted in 35, 15 and 56 studies respectively that were analyzed.

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Introduction: Regenerative peripheral nerve interfaces (RPNI) can be used to mitigate neuropathic pain resulting from nerve injury or neuroma formation following trauma, surgery, or amputation. Most of the current literature discusses the utility of RPNI for the treatment of neuropathic pain in the upper and lower extremities; however, RPNI can also improve neuropathic pain in non-extremity regions. Our objective was to characterize and describe patient cases of non-extremity RPNIs.

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Myoid hamartoma of the breast is an uncommon benign breast neoplasm. We describe an unusual example of an in-situ and invasive carcinoma arising in a myoid hamartoma. We also describe the unique molecular findings in the myoid hamartoma and review the pertinent literature.

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Background: Predictors for permanent nipple-areola complex (NAC) insensitivity after reduction mammoplasty are sparsely defined.

Objectives: We analyze factors associated with NAC insensitivity over a long-term follow-up.

Methods: A retrospective analysis of reduction mammoplasties on 1598 breasts performed by four surgeons from March 2015-February 2023 was conducted.

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Surgical treatments for metastatic spine tumors have evolved tremendously over the last decade. Improvements in immunotherapies and other medical treatments have led to longer life expectancy in cancer patients. This, in turn, has led to an increase in the incidence of metastatic spine tumors.

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Article Synopsis
  • The study investigates trans-inclusive educational programming at U.S. medical and public health schools by collecting survey responses from deans and administrators.
  • Data collection occurred between December 2019 and February 2020, targeting social and structural aspects of programming, with a focus on training, events, admissions, and policies.
  • Results showed significant differences in trans-inclusive strategies between medical and public health schools, highlighting the need for stronger policies to support trans inclusion, such as mentorship and using students' preferred names and pronouns.
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Importance: Understanding the diagnostic accuracy of postoperative trial of void (TOV) parameters is important for decision making related to postoperative catheterization.

Objective: The aim of the study was to compare the diagnostic accuracies of common postoperative TOV parameters.

Design: The study population comprised a prospective cohort undergoing outpatient urogynecologic procedures at a tertiary referral center from September 2018 to June 2021.

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Introduction: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have shown efficacy in the context of heart failure but have not been well-studied in ischemic heart disease. We employed a large animal model of chronic coronary artery disease and metabolic syndrome (MS) to investigate the hemodynamic and metabolic consequences of SGLT2i administration.

Methods: Thirty-eight Yorkshire swine were divided into two groups, with half (n = 21) receiving a high fat diet to induce MS, and the other half fed a standard diet (n = 17).

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Article Synopsis
  • The study aimed to analyze how the gender of urologic surgeons affects their participation in robotic-assisted laparoscopic surgeries (RALS) from 2012 to 2022 using surgical case logs.
  • Results showed that women performed only 10.8% of all procedures and 9.02% of robotic cases, with the highest involvement in sacrocolpopexies.
  • The findings suggest significant gender disparities in RALS participation, highlighting the need for equitable training opportunities and further research into factors like mentorship and practice settings.
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Conquering Insulin Network Dysfunctions in Alzheimer's Disease: Where Are We Today?

J Alzheimers Dis

October 2024

Departments of Pathology and Laboratory Medicine, Medicine, Neurology and Neurosurgery, Rhode Island Hospital, Lifespan Academic Institutions, and the Warren Alpert Medical School of Brown University, Providence, RI, USA.

Article Synopsis
  • Impairments in insulin and IGF signaling in the brain contribute to energy metabolism issues, which are linked to the neurodegeneration seen in Alzheimer's disease, resulting in various brain cell damage and cognitive decline.
  • Similar neuropathological processes are observed in other conditions like type 2 diabetes and Parkinson's disease, suggesting common underlying mechanisms.
  • Current research is exploring repurposing diabetes medications for Alzheimer's treatment, indicating a need for comprehensive strategies that target multiple signaling pathways to effectively address neurodegeneration.
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  • The study investigates the occurrence, causes, treatment, and recovery times of ulnar collateral ligament (UCL) injuries in NFL quarterbacks between 1991 and 2023.
  • A total of 21 injuries were recorded, with most occurring in players aged around 29, primarily as noncontact injuries, and often managed without surgery.
  • While average recovery time was about 166 days, those requiring surgical reconstruction faced significantly longer recovery; additionally, recent injuries correlated with better performance after recovery compared to older injuries.
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In recent decades, artificial intelligence (AI) has infiltrated a variety of domains, including media, education, and medicine. There exists no glossary, lexicon, or reference for the uninitiated medical professional to explore the new terminology. As AI-driven technologies and applications become more available for clinical use in healthcare settings, an understanding of basic components, models, and tasks related to AI is crucial for clinical and academic appraisal.

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Article Synopsis
  • The COVID-19 pandemic worsened existing socioeconomic and racial disparities, prompting Morehouse School of Medicine to lead community vaccination efforts as part of their commitment to health equity.
  • From January 2021 to April 2022, they vaccinated over 2,700 individuals in the Atlanta area, primarily African American and Hispanic/Latino populations.
  • The initiative aimed to address vaccine access barriers and deliver culturally sensitive care, emphasizing the importance of equitable healthcare practices.
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Objectives: To characterize representation and inclusion among Sleep Research Society members and examine associations between sociodemographic features and Sleep Research Society experiences.

Methods: The Sleep Research Society Taskforce for Diversity and Inclusion developed a web-based questionnaire in 2021, assessing membership data and Sleep Research Society experiences (self-initiated and society-initiated participation, feeling very welcomed, perceptions of inclusiveness, and diversity of viewpoints represented). Frequencies were calculated and adjusted Poisson regression models with robust variance were fit to estimate associations.

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Dr. Thanjavur Santhanakrishna Kanaka significantly advanced Indian healthcare through her pioneering contributions to modern surgical techniques and advocacy for gender equity in medical education. Her research in stereotactic surgery and electrode implantation, coupled with her focus on cost-effective care for low-income patients, has had a profound impact on neurosurgery.

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Gerty Theresa Cori, a remarkable and pioneering biochemist, became the first woman to receive the Nobel Prize in Physiology or Medicine in 1947 for her groundbreaking research in carbohydrate metabolism. Her work, in collaboration with her husband Carl Ferdinand Cori, revolutionized the scientific understanding of carbohydrate metabolism and had a profound impact on medicine and human health. This paper offers a historical vignette of Gerty Cori's life, tracing her journey from her early years in Prague to her pivotal role in transforming biochemistry.

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Graduate Medical Education Financing in the US Department of Veterans Affairs.

Fed Pract

April 2024

Office of Academic Affiliations, Veterans Health Administration, Department of Veterans Affairs, Washington, DC.

Background: The US Department of Veterans Affairs (VA) partners with 250 sponsors of graduate medical education (GME), annually providing $850 million for 11,000 full-time equivalent resident positions that support veteran patient care and provide educational opportunities for trainees from affiliated academic programs. Knowledge of VA GME financing is vital to maintain these partnerships.

Observations: In response to increased scrutiny from several federal oversight bodies, the VA revised its GME reimbursement policy and procedures, including implementing new resident tracking and auditing mechanisms.

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Introduction:  This study is a retrospective review of patients who sustained out-of-hospital cardiac arrest due to ventricular fibrillation. The data were analyzed to decipher predictors of good outcomes as the overall survival rate in the county is significantly higher than the national average.

Methods: The inclusion criteria for the study comprised all patients over the age of 18 for whom a call was made for unresponsiveness.

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Pulmonary embolisms are serious complications that can arise from surgical procedures involving the extremities due to the risk of deep vein thrombosis (DVT) and subsequent embolism. This life-threatening condition occurs when an embolus lodges at the bifurcation of the main pulmonary arteries, compromising blood flow to the lungs. Treatment options for pulmonary embolism primarily include anticoagulation therapy, thrombolysis, thrombectomy, and inferior vena cava (IVC) filter placement.

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Article Synopsis
  • Childhood sleep quality is influenced by factors such as maternal stress during pregnancy and can predict later health outcomes.
  • The study examined data to understand how prenatal stress relates to sleep quality in children aged 4-8, finding that both prenatal and postnatal stress have significant effects.
  • Results indicate that postnatal stress mediates the impact of prenatal stress on sleep issues, highlighting the need for further research on maternal mental health and child sleep disturbances.
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  • Mary Putnam Jacobi was a key player in advocating for women's rights to medical education, pushing against societal myths about menstruation.
  • After being denied medical education in the U.S., she studied in Paris and established a women's curriculum comparable to Harvard’s standards.
  • Her research supported the capability of women in rigorous academic work and helped open doors for women in education and the workplace, leaving a lasting impact on the women's suffrage movement.
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Factors affecting problem-solving court team decisions about medications for opioid use disorder.

J Subst Use Addict Treat

January 2025

Department of Family Medicine and Community Health, University of Massachusetts Chan Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Electronic address:

Article Synopsis
  • Problem-solving courts (PSCs) aim to provide alternatives to traditional prosecution and support for individuals with drug-related issues, particularly those facing challenges with opioid use disorder, but medications like methadone and buprenorphine remain underutilized among PSC clients.
  • A study involving semi-structured interviews with 54 PSC staff across four states revealed that most courts have lifted blanket prohibitions on medication for opioid use disorder (MOUD) due to changes in policies and education, but staff preferences and concerns still influence individual client decisions.
  • The decision-making factors for allowing MOUD include the type of treatment provider, communication with the court, and adherence to certain criteria, with staff expressing more comfort towards buprenorphine than methadone
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  • The report discusses a unique case of invasive acantholytic anaplastic extramammary Paget disease (AAEMPD) found in an 87-year-old woman after multiple treatments for a persistent vulvar lesion.
  • Microscopic examination revealed unusual features such as intraepidermal acantholysis and atypical cell growth, raising concerns of both EMPD and invasive carcinoma.
  • Accurate diagnosis of AAEMPD is essential as it has different treatment strategies compared to other potential conditions, highlighting the need for careful assessment in clinical practice.
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Article Synopsis
  • The study aims to evaluate whether the structure of Graduate Medical Education teaching clinics affects how well ophthalmology residents train for independent clinical practice, measuring preparedness with the Readiness Index, which includes workload and supervision ratios.
  • Data was collected from 109 outpatient clinics across the Veterans Affairs system from 2015 to 2019, analyzing the productivity and supervision levels of residents as they cared for patients.
  • Results showed that senior residents from clinics with higher resident-to-physician ratios exhibited better readiness, primarily due to increased independent practice, while those in larger programs often handled more complex cases but didn't see the same level of practice readiness.
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