3,051 results match your criteria: "The University of the West Indies.[Affiliation]"

Novel lineage of anelloviruses with large genomes identified in dolphins.

J Virol

December 2024

The Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine, School of Life Sciences, Arizona State University, Tempe, Arizona, USA.

Unlabelled: Anellovirus infections are ubiquitous in mammals but lack any clear disease association, suggesting a commensal virus-host relationship. Although anelloviruses have been identified in numerous mammalian hosts, their presence in members of the family Delphinidae has yet to be reported. Here, using a metagenomic approach, we characterize complete anellovirus genomes ( = 69) from four Delphinidae host species: short-finned pilot whale (, = 19), killer whale (, = 9), false killer whale (, = 6), and pantropical spotted dolphin (, = 1).

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  • Spirometry is a test used to evaluate lung function by comparing it to normal levels in healthy non-smokers, focusing on metrics like forced vital capacity (FVC) and the FEV/FVC ratio.
  • The study analyzed data from over 14,000 participants aged 40 and older across 41 sites, revealing regional differences in FVC tied to factors like age and height, categorized into four regions: Europe/richer countries, Near East, Africa, and Far East.
  • Findings showed significant regional variations in FVC values between men and women, particularly in Europe compared to the Far East, but minimal differences in the FEV/FVC ratio across regions.
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The Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) Guidelines.

Wound Repair Regen

December 2024

Wound Healing and Regenerative Medicine Research Program, Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

Article Synopsis
  • Preclinical studies are crucial for developing therapies for wound healing disorders, offering safety screening and insights through in vivo approaches.
  • Current animal testing guidelines are inadequate due to the complexity of wound healing processes, leading to inconsistencies in study interpretation.
  • The newly established Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) Guidelines aim to standardize the reporting of experimental conditions in preclinical wound healing studies to improve transparency and support future clinical trials.
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  • Large household water storage containers are key breeding sites for Aedes aegypti mosquitoes, which spread diseases like dengue.
  • Concerns over insecticide resistance and safety are challenging effective mosquito control, leading researchers to explore RNAi-based yeast larvicides as a solution.
  • A study developed a shelf-stable, controlled-release yeast formulation that shows promise for lasting mosquito control, demonstrating effectiveness in various container sizes and remaining active for up to six months.
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Panniculitis in dermatomyositis: A systematic review of the clinicopathologic features.

JAAD Int

February 2025

Division of Dermatology, Department of Medicine, The University of the West Indies, Mona Campus, Kingston, Jamaica.

Background: Panniculitis in patients with dermatomyositis (PDMS) is rare.

Objectives: Assess the clinicopathologic features described for PDMS.

Methods: A systematic review of the PubMed/MEDLINE database was performed.

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Conventional and Nonconventional Therapies for COVID-19 Management in Trinidad.

Scientifica (Cairo)

November 2024

Department of Basic Veterinary Sciences, School of Veterinary Medicine, Faculty of Medical Sciences, The University of the West Indies, St. Augustine Campus, St. Augustine, Trinidad and Tobago.

This cross-sectional study investigated nonconventional therapies for COVID-19 in Trinidad, emphasizing the need for documentation supporting future pharmaceutical research. The survey, conducted from June 20 to July 19, 2022, garnered responses from 57 participants aged 18 and above, with 82.46% vaccinated.

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Background: The use of EQ-5D instruments in clinical, policy and economic applications continues to grow internationally. Population norms studies provide baseline values against which demographic and patient groups are compared and inequality is assessed. This study presents updated EQ-5D-5L population norms for 2022-2023, evaluates inequality and compares the results with those of 2012.

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  • There is a rising concern regarding problematic cannabis use (PCU) in low- and middle-income countries like Jamaica, where cannabis has a rich cultural history, highlighting the need for further research.
  • The study analyzed data from the Jamaica National Drug Prevalence Survey, focusing on 786 cannabis users to determine prevalence, sociodemographic factors, and psychosocial aspects linked to severe PCU.
  • Findings revealed that over half of the cannabis users had severe PCU, with males and younger adults being at higher risk, and factors like early cannabis use onset, easy access, and perceived treatment needs contributing to these high prevalence rates.
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Background: Adolescence is a crucial period for establishing healthy behaviours that can reduce the risk of noncommunicable diseases. However, limited data exist on the clustering of health-related behaviours, in adolescents from low- and middle-income countries (LMICs). This study examined how diet and physical activity behaviours cluster and how they are influenced by home and school area-level deprivation.

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A cross-sectional study of physiologic volar melanotic macules: Demographic, historical, clinical, and dermatoscopic features of a common yet neglected pigmentary variant in individuals with skin of color.

J Am Acad Dermatol

November 2024

Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Department of Dermatology, Harvard Medical School, Boston, Massachusetts. Electronic address:

Background: Physiologic volar melanotic macules (P-VMM) are understudied. Trauma has been suggested as a predisposing factor. Little has been published over the last several decades.

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  • * An analysis of 311 archived serum samples from a viral fever epidemic showed a 15.43% rate of IgG antibodies to the helminth, with higher rates in females, middle-aged adults (31-50 years), and in rural areas compared to urban settings.
  • * The findings suggest that serological testing, specifically the ELISA method used in this study, could effectively enhance understanding of the disease's epidemiology in Jamaica, particularly in regions with low endemicity.
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  • Lipodystrophy involves unusual fat distribution and can be linked to various causes; this review focuses on a young Afro-Caribbean female with partial lipodystrophy after a bone marrow transplant.
  • The text discusses diagnostic strategies for identifying lipodystrophy and offers follow-up recommendations for patients with this condition.
  • It aims to raise awareness about the potential development of lipodystrophy in childhood cancer survivors and its clinical significance.
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Diabetes and the associated complications: The role of antioxidants in diabetes therapy and care.

Biomed Pharmacother

December 2024

Department of Health Sciences, Texas A&M University, Corpus Christi, TX 78412, USA; Department of Life Sciences, Texas A&M University, Corpus Christi, TX 78412, USA. Electronic address:

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by high blood sugar levels (hyperglycemia). Poorly managed diabetes can lead to complications affecting multiple organ systems. Antioxidants play a crucial role in reducing oxidative stress caused by reactive oxygen species (ROS), primarily triggered by uncontrolled high blood sugar levels in diabetes.

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Viral myositis is an uncommon sequela associated with influenza virus infection, more common in children. We report a case of a three-year-old girl who developed viral myositis after suffering from influenza A infection. The patient was found to have leg pain associated with difficulty in walking.

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  • This systematic review and meta-analysis investigates the effectiveness and safety of rituximab (RTX) for treating idiopathic inflammatory myositis (IIM) by analyzing multiple studies through a systematic search of PubMed and Embase.
  • Seventeen studies involving 362 patients were included, revealing an overall response rate of 70%, with complete remission in 13% and partial response in 48%, indicating significant variation among different myositis types.
  • While RTX shows promise for IIM treatment, the notable side effects, including infusion reactions and infections, underscore the necessity for careful patient monitoring and further controlled trials to better understand long-term effects and establish treatment protocols.
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The molecular coordination of tuberization: Current status and future directions.

Curr Opin Plant Biol

December 2024

The Department of Life Sciences, Faculty of Science and Technology, The University of the West Indies, St. Augustine, Trinidad and Tobago.

The integration of bulk transcriptomic, proteomic, and genomic data generated from numerous systems biology studies of tuberizing plants has resulted in a better understanding of the molecular and morphological aspects of tuberization. The identified conserved integrated hormonal, transcriptional, and metabolic pathways of tuberization in crops from various plant lineages support the hypothesis of a fundamental tuberization process. However, further studies are required to specify the additional processes defined by the genomics and phylogeny of the particular plant lineages, which control the morphological diversity of tubers.

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This study examined a model of the associations among self-esteem, body dissatisfaction, and the drive for muscularity among Jamaican male weight lifters, and compared model relationships between weight lifters from rural and urban areas of residence. Using a purposive sampling approach, cross-sectional data were collected from 225 male weight lifters, ages 18-67 years ( = 28.16,  = 9.

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Background: Standard irrigating protocols during root canal treatment call for the use of sodium hypochlorite during chemo-mechanical preparation, followed by final irrigation with ethylenediaminetetraacetic acid (EDTA). This study determined the effectiveness of a new irrigant, Triton (Brasseler, USA), on smear layer removal during root canal treatment compared to that of 5.25% sodium hypochlorite and CanalPro EDTA 17% (Coltene).

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The coffee berry borer (CBB) Hypothenemus hampei was first described in Africa in 1867 and has spread to all major coffee-producing regions worldwide, including Jamaica. Using long-read sequencing, we produced a new high-quality reference genome (172.7 Mb) for the Jamaican strain of the CBB, with 93% of the genome assembled into 14 scaffolds.

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The need for effective primary healthcare to address social and structural determinants of health and to mitigate health inequalities has been well established. Here, we report on the international forum of the 2023 NAPCRG (formerly known as North American Primary Care Research Group) Annual Meeting. The aim of the forum was to develop principles for action for the primary healthcare research community on addressing social and structural determinants of health.

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Draft genome of hydrocarbon-degrader BCTT, isolated from soil chronically polluted with crude oil in Trinidad.

Microbiol Resour Announc

December 2024

Biochemistry Research Lab (Rm216), Department of Life Sciences, Faculty of Science and Technology, The University of the West Indies, St. Augustine, Trinidad and Tobago.

BCTT isolated from chronically polluted soil in Trinidad, shows a capacity to survive in crude oil as a sole carbon source. Here, we report its high-quality draft genome sequence and highlight those pathways and genes involved in xenobiotic degradation. These data give a clearer insight into this organism's biotechnological potential.

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Caribbean health research has overwhelmingly employed measures developed elsewhere and rarely includes evaluation of psychometric properties. Established measures are important for research and practice. Particularly, measures of stress and coping are needed.

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During the COVID-19 pandemic, hypertensive patients had increased infection and healthcare disruption in many low- and middle-income countries (LMICs) with limited vaccine access. The objective of this report is to describe COVID-19 experiences and vaccination uptake among hypertensive patients in Colombia and Jamaica. A cross-sectional study of patients with hypertension was conducted in primary care clinics in both countries between 2021 and 2022.

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Implementation of Antigen-Based Diagnostic Assays for Detection of Histoplasmosis and Cryptococcosis among Patients with Advanced HIV in Trinidad and Tobago: A Cross-Sectional Study.

J Fungi (Basel)

October 2024

Department of Communicable Diseases Prevention, Control, and Elimination, Pan American Health Organization, Washington, DC 20037, USA.

The Caribbean continues to have high HIV prevalence globally with concurrently high mortality rates due to opportunistic Infections. This study addresses the prevalence of histoplasmosis and cryptococcosis among patients living with advanced HIV disease (AHD) in Trinidad and Tobago, focusing on the implementation of antigen-based diagnostic assays. Conducted as a cross-sectional survey across five HIV treatment sites, 199 participants with advanced HIV disease were enrolled between July 2022 and September 2023.

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