2 results match your criteria: "The University of Wollongong and The Illawarra Health and Medical Research Institute[Affiliation]"
Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature.
Brain
June 2020
Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, 2109, NSW, Australia.
Article Synopsis
- Hyperphosphorylation and accumulation of tau protein in the brain are key features of frontotemporal dementia and Alzheimer's disease.
- Disease mutations in the tau gene allow for the creation of transgenic mouse models that mimic aspects of these neurodegenerative diseases, including tau-related changes in the brain.
- The study found that the expression of a mutant form of tau (P301S) led to learning difficulties and impaired neuronal network function in mice, with increased activity in early response genes indicating that tau pathology disrupts normal neuron behavior, ultimately contributing to memory loss.
Bacterial Sliding Clamp Inhibitors that Mimic the Sequential Binding Mechanism of Endogenous Linear Motifs.
J Med Chem
June 2015
†School of Chemistry and Centre for Medical and Molecular Bioscience, The University of Wollongong and The Illawarra Health and Medical Research Institute, Wollongong, New South Wales 2522, Australia.
The bacterial DNA replication machinery presents new targets for the development of antibiotics acting via novel mechanisms. One such target is the protein-protein interaction between the DNA sliding clamp and the conserved peptide linear motifs in DNA polymerases. We previously established that binding of linear motifs to the Escherichia coli sliding clamp occurs via a sequential mechanism that involves two subsites (I and II).
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